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UK universities and research institutes were invited to submit applications, working in equitable partnerships with researchers in low- and middle-income countries (LMIC), to develop their ambitions to deliver world-class applied global health research to address under-funded or under-researched global health areas specific to those countries.. 1) Deliver the UK's ambition to be internationally outstanding in global health research, improving the lives of people in LMIC. 2) Create an environment where world-class global health research, focused on the needs of LMIC can thrive. 3) Translate advances in applied global health research into benefits for patients and the public in LMIC. 4) Focus on priority areas which will have the greatest impact on health in LMIC in the short, medium and long term. 5) Provide high quality research evidence to inform decision-making by public health officials, practitioners and policy makers. 6) Increase the volume and quality of multi-disciplinary global health research from the UK. 7) Develop knowledge and capacity within existing UK institutions which can be translated into global health research practice.\n \n ID: GB-GOV-10-17_63_08\nTitle: NIHR Global Health Research Group on Preterm Birth and Stillbirth (the DIPLOMATIC Collaboration)\nDescription: A UK and low- and middle-income country (LMIC) partnership that aims to reduce preterm birth and stillbirth and to optimise outcomes for babies born preterm. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs.. 1) Enhance clinical care strategies for the prevention of stillbirth and preterm birth in Malawi and Zambia, reducing rates of preterm birth, stillbirth and under-5 deaths. 2) Generate new knowledge on the effectiveness of interventions and on how best to implement them. 3) Develop a clinical trials platform to test novel interventions, initially for stillbirth and preterm birth, but longterm in an NIHR unit on maternal newborn global health. 4) Enhance the collection of perinatal outcomes in vital statistics and hospital datasets. 5) Increase the accuracy of prematurity estimates by using first trimester ultrasound scanning to optimise assessment of gestational age.\n \n ID: GB-GOV-10-17_63_20\nTitle: NIHR Global Health Research Group on Respiratory Rehabilitation (Global RECHARGE)\nDescription: A UK and low- and middle-income country (LMIC) partnership that aims to deliver an intervention to reduce disability through pulmonary rehabilitation in Kyrgyzstan, Uganda, India and Sri Lanka. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs.. 1) Understand the challenges of providing a pulmonary rehabilitation (PR) in LMIC countries. 2) Establish culturally appropriate and innovative methods of delivering PR in LMIC partner sites and evaluate the new PR programmes. 3) Understand the workforce and training issues in the LMIC partners to support the delivery of clinically effective PR programmes. 4) Set priorities and outcome measures for the delivery and evaluation of a co-produced PR programme. 5) Develop an international standardised database (with anonymised individual patient data) to allow international benchmarking of PR programmes and to strengthen infrastructure for future research in this area. 6) Develop multi-disciplinary research capacity, strong governance and data management.\n \n ID: GB-GOV-10-17_63_26\nTitle: NIHR Global Health Research Group on Preterm Birth Prevention and Management (PRIME)\nDescription: A UK and low- and middle-income country (LMIC) partnership that aims to address the challenges of preterm birth in LMICs, where its prevalence is highest. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs.. 1) Synthesise current knowledge and define the evidence gap in low and middle income countries (LMICs) regarding the prevalence, pattern, and perinatal management of pre-term birth (PTB) 2) Carry out a series of network research events to focus on understanding differential access, experiences and outcomes in advantaged and deprived populations. 3) Determine a research agenda (immediate, medium-, and long-term) relevant to each LMIC, to be developed/implemented during the term of the project and beyond. 4) Develop prenatal and postnatal evidence- based multi-professional guidelines for perinatal care for PTB. 5) Carry out pilot studies on term and preterm placentas to improve understanding of the contribution of these specific, often endemic, infections in LMICs to PTB in order to inform new research priorities around prevention of, and screening for identified infections. 6) Carry out vaginal swab studies in partner LMICs and explore at stakeholder-led research prioritisation exercises whether future studies of cervical electrical impedance spectroscopy (EIS) devices would be feasible, practical and acceptable in LMICs contexts. 7) Work directly with the Project Management Group to provide patient and public involvement (PPI) input into all project matter. \n\nFollowing a costed extension, additional objectives will include:\nWork Package 1: Work with families, health care workers and policy planners.\n1. Design and carry out pilot/ feasibility studies of interventions to improve adolescent sexual reproductive health (SRH), prevent unintended pregnancy, and reduce miscarriage, preterm birth (PTB), and “small for dates” in three locations.\n2. Develop need-based and culturally sensitive intervention packages to improve adolescent SRH, antenatal care (ANC) and nutrition.\n3. Test the feasibility of implementation, health systems integration, geographical scale-up and sustainability of these interventions.\n\nWork Package 2: Employ metagenomics/ transcriptomics to identify viral pathogens in preterm vs. term placental tissues already collected from UK and Bangladesh women by 03/2021.\n\nWork Package 3: Bridge the gap between research findings, policy and practice.\n1. Implement PRIME (PReterm bIrth prevention and manageMEnt) research outputs (PTB guidelines, education and training resources by engagement/ advocacy workshops with families, healthcare workers, policy planners, and non-government organisations.\n2. Systematically capture the impact of PRIME research outputs.\n \n ID: GB-GOV-10-17_63_35\nTitle: NIHR Global Health Research Group on Estimating the Prevalence, Quality of Life, Economic and Societal Impact of Arthritis in Tanzania\nDescription: A UK and low- and middle-income country (LMIC) partnership that aims to establish a centre of excellence in Tanzania in social science research to understand the distribution and impact of arthritis in Tanzania and inform prevention and intervention plans. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs.. 1) Establish new research collaborations between Universities of Glasgow/Newcastle and Kilimanjaro Clincial Research Institute. 2) Understand and describe the lived experience of joint pain and arthritis in Tanzania. 3) Describe how the ‘arthritis and joint pain’ problem is managed in clinical settings. 4) Estimate the prevalence of the main forms of arthritis in community settings in Tanzania. 5) Identify existing evidence on arthritis quality of life, health seeking behaviour and resource utilisation and pilot instruments. 6) Increase training and capacity building in social science in Tanzania.\nFollowing a costed extension, additional objectives will include:\n\nStudy 1: Evaluate a new rheumatology clinic through documenting and evaluating the process by which the clinic is established, who is referred, how patients are identified and managed, and short-term outcomes.\n1. Describe the socio-demographics, clinical characteristics and short-term outcomes of patients.\n2. Evaluate the processes through which the clinic is established and identify future directions.\n\nStudy 2: Identify culturally relevant attributes of capacity wellbeing by building directly on initial qualitative findings.\n1. Conduct formative qualitative research to inform the development of a future instrument for intervention evaluation research into non-communicable diseases.\n \n ID: GB-GOV-10-17_63_38\nTitle: NIHR Global Health Research Group on Improving Asthma Outcomes in African Children\nDescription: A UK and low- and middle-income country (LMIC) partnership that aims to assess asthma control, current treatment, knowledge of and attitudes to asthma in African schools, and the barriers to achieving good control in 3000 asthmatic children aged 12 to 14 years in schools in six African countries, utilising data to design a school-based intervention. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs.. 1) Adaption of a UK online asthma survey for schools so that it is applicable to secondary schoolchildren in urban Africa via focus groups of asthmatic children at each centre. 2) Provide the survey online to children aged 12 to 14 years presenting to secondary care with an acute asthma attack in order to generate data from asthmatic children who may not be attending school. 3) Since there are many phenotypes of asthma, the group will phenotype children with asthma by; i) pre-and postbronchodilator spirometry, ii) exhaled nitric oxide (FeNO), a marker of airway eosinophilia, and iii) by the reported pattern of wheeze (e.g. predominately viral-triggered attacks, persistent wheeze with with atopic symptoms). To obtain objective data on medication adherence, and daily changes in lung function, a subgroup of children will be provided with a mobile smart phone, a personal peak flow device, and inhaler adherence assessment technology. Real-time data on adherence and lung function will be delivered via mobile technology to the data platform.\n\nFollowing a costed extension, additional objectives will include:\n1. Describe the burden of microenvironmental air pollution exposure in urban children with asthma symptoms in sub-Saharan Africa.\n\n2. Explore connections of air pollution exposure to lung health and function in these children.\n\n3. Collect personal air pollution exposure data, lung function and exhaled nitric oxide, and activity profiled from 420 children with asthma symptoms aged between 12 and 16 in 7 African cities.\n\n4. Analyse personal air pollution data for exposure patterns and peak exposures, and to compare air pollution and activity profiles of children in relation to their socioeconomic and geographical backgrounds.\n\n5. Explore potentially detrimental effects of air pollution and feasibility of potential mitigation strategies in children with asthma symptoms identified by ACACIA (Achieving Control of Asthma in Children in Africa).\n \n ID: GB-GOV-10-17_63_42\nTitle: NIHR Global Health Research Group on Sepsis\nDescription: A UK and low- and middle-income country (LMIC) partnership that aims to advance a multidisciplinary approach to address the problem of sepsis in sub-Saharan Africa. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs.. 1) Sustainably improve sepsis research training. 2) Reach consensus on research priorities and sepsis care quality indicators for Africa. 3) Pilot test innovative sepsis care interventions. 4) Test novel clinical trial platforms to answer key sepsis questions for Africa.\n\n\nFollowing a costed extension, additional objectives will include:\nWork Package 1 : Extend cohort enrolment by 6-12 months dependent on site.\n1. Improve estimate precision of hospital admission over a longer time period.\n2. Provide sufficient numbers for investigating post-discharge mortality, morbidity, and re-hospitalisation risk factors.\n\nWork Package 2: Host response to sepsis. Inclusion of transcriptomic or immunological profiles to facilitate patient stratification into subgroups (endotypes).\n1. Compare sepsis endotypes between High Income Countries and Low and Middle Income Countries.\n2. Develop an accurate temporal association of endotypes and clinical outcomes for patients in Malawi and Uganda.\n3. Identify transcriptomic biomarkers for validation of a pan-sepsis prognostic panel.\n\nWork Package 3: Expand the capabilities of the BASIS research network (addition of three countries to the current core sites).\n1. Describe important differences in the presenting features of patients with sepsis in African hospitals.\n\nWork Package 4: Refinement of the eSIMS (electronic Severe Illness Management Support) platform.\n1. Add functionality informed by the current work.\n2. Evaluate whether eSIMS impacts the processes of sepsis care in platform-naïve health facilities\n \n ID: GB-GOV-10-17_63_47\nTitle: NIHR Global Health Research Group on a Package of Care for the Mental Health of Survivors of Violence in South Asia\nDescription: A UK and low- and middle-income country (LMIC) partnership that aims to develop a comprehensive, adaptable package of care to improve the mental health of survivors of violence against women (VAW), modern slavery, and civil conflict in resource-constrained settings in South Asia. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs.. 1) Identify candidate interventions through systematic review and expert networks. Through household and institutional surveys, augment existing partner data with quantitative and qualitative information on mental health burden, needs, stigma, and care-seeking. Through interviews and workshops, work with survivors and providers to understand local perspectives, mental health and social support services, intervention opportunities, and potential resources. 2) Collaborate with survivors and providers to pinpoint promising interventions and opportunities, barriers to uptake, and potential unintended outcomes. Through workshops and consultation, co-develop theories of change and delineate a provisional intervention package. 3) Pilot interventions to understand feasibility (cultural appropriateness, delivery, uptake, barriers and enablers), acceptability (motivations and expectations, safety and unintended outcomes), and potential effectiveness.\n\nFollowing a costed extension, additional objectives will include:\nWork Package 1: Further research\n1. Improve the mental health of survivors of violence by extending the current package of care to adolescent girls and boys aged 15-19 years.\n2. Additional nested studies led by Early Career Researchers (ECRs).\n\nWork Package 2: Enhance dissemination and impact.\n1. Present package of care to government and civil society stakeholders at a regional event in India.\n\nWork Package 3: Career development for ECRs.\n1. Organise and lead an international symposium immediately following the dissemination event.\n2. Have ECRs design and lead their own nested studies on dating violence and with mothers-in-law of young women.\n \n ID: GB-GOV-10-17_63_62\nTitle: NIHR Global Health Research Group on Asthma Attacks Causes and Prevention Study in Urban Latin America\nDescription: A UK and low- and middle-income country (LMIC) partnership that aims to study causes of and test a strategy to prevent asthma attacks in Latin America, focussing on underserved urban settings in Brazil and Ecuador, with high levels of inequality. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs.. 1) Set up a Global Health Research Group at St George’s in collaboration with key partners in Brazil, Ecuador, and the UK. 2) Deliver a programme of implementation and epidemiological research through prevention of severe asthma attacks among adults in Brazil and asthma attacks in children and adolescents in Ecuador, and identification of risk factors associated with asthma attacks and recurrence of asthma attacks. 3) Establish collaborative links with LMIC partners by strengthening existing links with Brazilian and Ecuadorian partners, establishing new links with academic institutions in Ecuador involved in asthma research and control and establishing new/ strengthening existing links with key stakeholders including Ministries of Public Health, municipal departments of health, national respiratory societies, other NGOs and patient groups in Ecuador and Brazil. 4) Develop research capacity through short to extended periods of research training and exchanges between Brazil and Ecuador. Short exchanges will be funded through this programme while extended periods will be funded through alternative sources within Brazil and Ecuador.\n \n ID: GB-GOV-10-17_63_66\nTitle: NIHR Global Health Research Group on Stroke\nDescription: A UK and low- and middle-income country (LMIC) partnership that aims to integrate existing stroke research excellence with healthcare and training infrastructures to improve stroke outcomes for people in Sierra Leone within five years. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs.. 1) Facilitate links with the UK, Ghana and Sierra Leone to set up the Stroke Unit at Connaught Hospital (Sierra Leone). 2) Deliver stroke specialist training to nurses to improve quality of care. 3) Facilitate a stroke team at 34 Military Hospital (Sierra Leone). 4) Train research and clinical staff in GCP, consent, and data collection and management.\n \n ID: GB-GOV-10-17_63_76\nTitle: NIHR Global Health Research Group on Addressing Smokeless Tobacco and Building Research Capacity in South Asia (ASTRA)\nDescription: A UK and low- and middle-income country (LMIC) partnership that aims to use Medical Research Council (MRC) frameworks on natural experiments and complex interventions to guide the development and evaluation of interventions on smokeless tobacco (ST) and to assess policies in Bangladesh, India and Pakistan, where 85% of the world’s 300 million ST users live and use the most lethal ST forms. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs.. 1) Enhance the ability to monitor and evaluate the impact of existing WHO-FCTC policies on smokeless tobacco (ST) uptake, particularly among adolescents, by providing a strong evidence-base for future policy development. 2) Design/adapt behavioural and pharmacological interventions to help adult ST users quit, test their feasibility and acceptability, and assess whether definitive trials to assess their (cost-) effectiveness can be carried out. 3) Engage stakeholders in the research plans, co-creation and knowledge transfer activities and advocacy efforts, thereby enhancing the translation and impact of the findings. 4) Build research capacity in participating institutions in South Asia by offering bespoke training in tobacco prevention and control science and applied health research, sharing examples of good practice, offering mentorship and helping them to secure research fellowships/studentships. 5) Sustain and scale up research activities through a strong research team, establishing institutional links with academic, governmental and advocacy organisations, seeking additional funding and involving more countries.\n \n ID: GB-GOV-10-17_63_82\nTitle: NIHR Global Health Research Group on the Application of Genomics and Modelling to the Control of Virus Pathogens (GeMVi) in East Africa\nDescription: A UK and low- and middle-income country (LMIC) partnership that aims to redress the imbalance of understanding, community spread and optimal control of infection diseases in East Africa. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs.. 1) Create a sustainable collaborative network of institutes (UK and East Africa) that collectively support applied virus epidemiological research and provide an evidence base for decision making by public health authorities in East Africa. 2) Provide training and research support for a cohort of 20 quantitative East African scientists to develop advanced skills in viral genomics and predictive modelling. This will enable them to address locally defined problems and input into country-specific recommendations. 3) Establish and transfer genome sequencing methods (eg compact real-time Nanopore technology) with associated analysis steps (or pipelines) for virus Next Generation Sequence (NGS) data, and construct mathematical models to predict the impact of different intervention options. Outputs will be open source resources for combining sequence and epidemiological data analysis with transmission dynamic modelling. 4) Develop the Zeeman Institute at the University of Warwick as a centre of expertise for integrated mathematical and genomic epidemiology, with meaningful ties to East African Institutes. 5) Establish an East African Alliance for Virus Prevention and Control Preparedness (VPCP) with the aim of coordinating research-evidenced responses to public health needs.\n\nFollowing a costed extension, additional objectives will include:\nWork Package 1: Enhance public health virus surveillance and research through cost-effective next generation sequencing (NGS) capacity in public health laboratories across the East African Region.\n1. Use of the low-cost portable Oxford Nanopore Technology NGS platform MinION in Low and Middle Income Country laboratories to allow pathogen whole genome sequencing.\n\nWork Package 2: Strengthen the role of mathematical modelling in providing evidence for public health decision making.\n1. Establish greater modelling capacity at KWTRP, Nairobi by linking health systems and economics teams with university departments and relevant Ministry of Health departments.\n \n ID: GB-GOV-10-17_63_91\nTitle: NIHR Global Health Research Group on Genomic Surveillance of Malaria in West Africa\nDescription: A UK and low- and middle-income country (LMIC) partnership that aims to establish local capacity in West Africa for genomic surveillance of malaria parasites and vectors, and to develop analytical outputs that will be of practical value to National Malaria Control Programmes (NMCPs) in planning effective interventions in the face of increasing drug and insecticide resistance. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs.. 1) Establish laboratory and computational systems for genomic surveillance of malaria at the University of Ghana in Accra and the Medical Research Council (MRC) Unit in The Gambia. 2) Work with local partners to optimise the pipeline for reliability, scalability and cost-effectiveness, and to learn how to integrate it most effectively into NMCP operations. 3) We aim to learn how to translate genomic data into actionable knowledge, e.g. by providing early warning of newly emerging resistance, and by showing how specific interventions are causing levels of resistance to rise or fall. 4) Develop sufficient proof of concept to start integrating these systems into the routine working practices of NMCPs in Ghana and The Gambia, and to provide a working example of how such systems could be deployed at other locations in Africa.\n\n \n ID: GB-GOV-10-17_63_110\nTitle: NIHR Global Health Research Group on Improving the Management of Acute Brain Infections\nDescription: A UK and low- and middle-income country (LMIC) partnership that aims to improve the diagnosis of acute brain infections in adults and children, guide treatment and improve outcomes, while developing research capacity and establishing a broad network of hospitals interested in studying brain infections. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs.. 1) Understand the behaviours, knowledge, attitudes and practice of patients, families and health care workers to suspected brain infection through interviews and focus group discussions. 2) Improve early management through development of a compound intervention by working with service users and providers to develop an intervention which improves patient management, and addresses underuse of lumber puncture, and inadequate laboratory methods. 3) Strengthen diagnosis through pathogen discovery and host genomic approaches. 4) Consider the funding impacts of any changes in care in advance of their development, to help determine if they are worth exploring, and the cost at which they might be implemented. 5) Provide training, capacity building and long-term sustainability to include studentships on the Masters in Research, PhD exchange projects, short course staff training, and online research training modules, both generic and specific to brain infections, offered through partnership with the Global Health Research Network.\n \n ID: GB-GOV-10-17_63_121\nTitle: NIHR Global Health Research Group on Atrial Fibrillation Management\nDescription: A UK and low- and middle-income country (LMIC) partnership that aims to build and establish long-term, sustainable collaborations in China, Brazil and Sri Lanka to increase research capacity and atrial fibrillation (AF) education/awareness amongst key stakeholders through co-developed, culturally-adapted, community-based approaches, and deliver locally-focused evidence-based research investigating developments of pragmatic patient pathways to generate further funding opportunities. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs.. 1) Develop and consolidate sustainable collaboration, shared vision and links with patients and policy makers to sustainably improve local services. 2) Strengthen community-based research culture, including patient and public involvement (PPI), and capacity to improve understanding of atrial fibrillation (AF) and improve health outcomes. 3) To adapt, with PPI, and assess feasibility of prioritised evidence-based sustainable pharmacological and behavioural approaches for integrated AF management within the resource confines of local health systems. 4) To develop, with PPI, and test feasibility of culturally-adapted, community-based approaches to increase education/awareness and to provide sufficient knowledge (patient, families, HCP) about AF and its complications to empower patients. 5) To provide evidence and develop local models of best care for local policy makers to improve well-being of AF patients and provide a template for extending this work to other chronic conditions. 6) To build a sustainable research platform within partner countries for future collaborations.\n \n ID: GB-GOV-10-17_63_125\nTitle: NIHR Global Health Research Group on Health System Responses to Violence Against Women\nDescription: A UK and low- and middle-income country (LMIC) partnership that aims to support health care systems to respond effectively to women subjected to violence, and build mixed-method gender violence research capacity in Nepal, Sri Lanka, the Occupied Palestinian Territories and Brazil. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs.. 1) Evaluate the readiness of the Brazilian, Occupied Palestinian Territory/West Bank (OPT/WB), Nepalese and Sri Lankan sexual and reproductive health services to identify violence against women (VAW), respond to the needs of women experiencing violence, and offer referral to VAW services. 2) Conduct research studies with patients and providers to inform the development of the intervention. 3) Develop a tailored training and support intervention for health care professionals with stakeholder involvement. 4) Pilot the intervention in reproductive and sexual health settings (all collaborating countries) and primary care settings (Nepal and Sri Lanka).\n \n ID: GB-GOV-10-17_63_130\nTitle: NIHR Global Health Research Group on Improving Outcomes in Mental and Physical Multimorbidity and Developing Research Capacity (IMPACT) in South Asia\nDescription: A UK and low- and middle-income country (LMIC) partnership that aims to improve the physical health of people with severe mental illness and the mental health of people with chronic physical conditions in LMICs. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs.. 1) Improve health and reduce deaths associated with diabetes, heart and lung diseases in people with severe mental illness (SMI) by addressing the most common health risk behaviours identified by a physical health survey, assembling a cohort of people who can be approached for future research and by designing interventions aimed at changing health risk behaviours (tobacco, physical activity, alcohol and diet) based on a brief talking therapy. 2) Reduce depression and anxiety in people with chronic physical health conditions by integrating the detection and treatment of depression/anxiety into an intervention package for chronic diseases delivered in primary care. 3) Build research teams and capacity to secure competitive funding and delivery world class applied health research informing policy and practice in these areas.\n\nFollowing a costed extension, additional objectives will include:\nWork stream 1: Conduct workshops with a range of stakeholders to understand facilitators and barriers to integrating services for identifying and managing depression in tuberculosis (TB) and chronic hepatitis services.\n1. Train staff in TB and hepatitis services to identify depression and deliver treatment.\n2. Provide specialist supervision for non-mental health specialists in those settings.\n3. Release staff and other resources to help integrate depression care.\n4. Scale up and sustain integrated provision.\n5. Explore with patients the acceptability of routine depression case-finding and treatment within TB/ chronic hepatitis care and potential adverse outcomes of integration.\n\nWork stream 2: Run co-designed workshops with patients and healthcare staff to develop plans, pathways and materials for integrating depression care in TB and chronic hepatitis services.\n\nWork stream 3: Test feasibility of plans and materials for depression case-finding.\n1. Identify and train staff in exemplar sites to case find using standard instruments.\n2. Collect quantitative and qualitative data form audits, focus groups and individual interviews.\n3. Revise plans, materials, future intervention and trial design based on results.\n4. Develop new partnerships with National TB programmes and hepatitis services in partner countries.\n5. Continued capacity-strengthening and skill development for early career researchers.\n \n ID: GB-GOV-10-17_63_131\nTitle: NIHR Global Health Research Group on Improving Outcomes in Sub-Saharan African Diabetes Through Better Diagnosis and Treatment\nDescription: A UK and low- and middle-income country (LMIC) partnership that aims to build on existing relationships between Exeter and leading partners in Uganda and Cameroon to form a collaborative, multi-disciplinary research group to answer fundamental questions for diabetes detection and treatment needed for effective patient care, train the next generation of clinical researchers, and build crucial research capacity in sub-Saharan Africa. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs.. 1) Create the foundation of a long-term partnership between Exeter and researchers, healthcare professionals and patient groups in Uganda and Cameroon to identify, design and perform critical research to improve the care of people with diabetes in sub-Saharan Africa (SSA). 2) Strengthen research capacity in SSA through an extensive programme of training in Exeter for African researchers at all levels, and reciprocal placements of UK researchers in African institutions. 3) Conduct initial studies to determine the best methods for detection and monitoring of different diabetes subtypes found in SSA, aiming to find practical solutions that make the best use of limited resources. 4) Establish long term studies (cohorts) of patients with diabetes in SSA that will form the basis of future research into the best treatment of diabetes in this population.\n\nFollowing a costed extension, additional objectives will include:\nOverall aim: To understand the pathogenesis and characteristics of thin non-autoimmune diabetes to optimise their identification, diabetes classification, prevention and treatment in sub-Saharan Africa.\n1. Use cohort data from the original award to identify characteristics at diagnosis that discriminate autoimmune (Type 1) from non-autoimmune (Type 2) diabetes and assess diagnostic performance to inform clinical guidelines.\n2. Perform preliminary studies to determine the contribution of insulin resistance and beta cell failure in the pathogenesis of thin non-autoimmune diabetes and explore the role of ectopic fat and pancreatic disease.\n3. Perform a pilot study assessing response to oral therapy in those with non-obese Type 2 diabetes previously thought to have Type 1 diabetes.\n4. Use initial findings from these studies to design a future large program of work for understanding pathogenesis, prevention and treatment.\n \n ID: GB-GOV-10-17_63_145\nTitle: NIHR Global Health Research Group: 'From Surviving to Thriving' \nDescription: A UK and low- and middle-income country (LMIC) partnership that aims to offer a holistic assessment of the occupational health risks to which urban informal workers are exposed in Zimbabwe and India, including consideration of climate-related risks, and identify priority interventions to address risks, strengthen assets and promote public, environmental and occupational health while also enhancing informal workers' resilience to climate change. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs.. 1) Assess and promote the health of informal workers, including those who work and live in informal settlements (hereafter ‘informal workers’). 2) Analyse the key health determinants and health outcomes for informal workers and those living in informal settlements, the interaction between these in relation to public health, occupational health and environmental health and how current and projected impacts of climate change affect this interaction. 3) Ascertain the approaches being used by informal workers to mitigate risks and enhance benefits. 4) Use these findings to identify the priority interventions to address risks, strengthen assets, promote public, environmental, and occupational health, enhance informal workers’ resilience to climate change and to promote workers’ well-being, and complement the rising interest in slum health, occupational health, and resilient urban development.\n \n ID: GB-GOV-10-17_63_154\nTitle: NIHR Global Health Research Group: 1000 DaysPlus Global Nutrition Research Group\nDescription: A UK and low- and middle-income country (LMIC) partnership that aims to develop context-appropriate interventions to optimise nutrition preconception, intra- and postpartum, which are likely to set-up better health and human capital trajectories. The network will deliver substantial societal and economic benefits, building LMIC partner capacity and improving knowledge for human health. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs.. 1) Establish a multidisciplinary group of researchers across SSA, with UK Southampton. 2) Undertake in-depth review of nutrition policy and engagement of health policy-makers and healthcare leaders with the issue, in three different SSA countries, to establish the barriers and the opportunities to instituting a clear 1000 DaysPlus double duty healthy nutrition policy. 3) Formulate the economic case for investment in nutrition in the 1000 DaysPlus for optimal health of people and their future offspring. 4) Leverage their on-going work in different contexts and with a range of stakeholders to identify the best 1000 DaysPlus nutrition interventions that could be embedded in ongoing reproductive health services, community health worker programmes, community antenatal care clinics, or fiscal measures (for example, sugar sweetened beverage tax). 5) Develop protocols and pilot novel approaches to improve the nutritional status in the 1000 DaysPlus period.\n \n ID: GB-GOV-10-17_63_155\nTitle: NIHR Global Health Research Group on Clean Energy Access for the Prevention of Non-Communicable Disease in Africa Through Clean Air\nDescription: A UK and low- and middle-income country (LMIC) partnership that aims to conduct high quality translational research supporting sustained, evidenced-based equitable transition to clean household energy at scale in Cameroon, Kenya and Ghana, demonstrating the health (through reductions in non-communicable disease), health inequalities and climate impacts of this transition. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs.. 1) Inform strategies to support more equitable uptake of clean fuel across the population by evaluating enabling/ inhibiting factors and testing interventions to address identified barriers and facilitate equitable adoption/ use of liquified petrolium gas (LPG) (including consumer finance solutions). 2) Estimate the impacts of scaled LPG adoption, in line with governmental targets, on health and climate by using advanced statistical techniques, thereby providing evidence for national/international policymakers to advocate for widespread transition to clean fuel. 3) Develop capacity through health systems strengthening in the partner countries, equipping health practitioners to intervene early to ‘prescribe’ clean household energy solutions to their patients. 4) Facilitate engagement between the general public and policymakers as research is undertaken alongside national policy implementation.\n", "_version_":1876173827051880448 }] } }