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Strengthen research management capability and institutional sustainability in partner countries. \n \n ID: GB-GOV-10-GHRG_5_163838\nTitle: NIHR Global Health Research Group on East Africa AMR-STOP: Strategies for Tackling, Optimising and Preventing Environmental AMR\nDescription: East Africa AMR-STOP (Africa AMR-STOP) is a transnational, interdisciplinary initiative addressing antimicrobial resistance (AMR), a critical threat to human, animal, and environmental health. Our goal is to combat AMR. We will do this by improving monitoring and surveillance and implementing innovative aerated constructed wetlands interventions. We will enhance AMR knowledge and build capacity for community health volunteers/village health teams, communities at village level, and professionals in water and environment sectors. We will also develop an online central service platform for training, management, and sharing of AMR data and tools, explore community engagement and involvement for reducing AMR spread, and assess the economic cost and cost-effectiveness of interventions.\n\nThe project will be undertaken by Makerere University in Uganda, Masinde Muliro University of Science and Technology in Kenya, South African Medical Research Council in South Africa, and University of Pretoria in South Africa.\n\nThe main aim is to co-develop a one health approach to mitigate and manage environmental AMR for enhancing health and wellbeing in Kenya and Uganda between February 2026 to January 2030.\n\nAMR is a critical global public health issue that can lead to fatal outcomes if not controlled. Low- and middle-income countries (LMICs) bear a disproportionate burden of AMR due to weak monitoring and wastewater treatment plants that don't work but are known to be major sources of antibiotic residues, antibiotic-resistant bacteria and antimicrobial resistance genes (ARGs) in the environment. In East Africa, untreated wastewaters from hospitals, pharmaceuticals, households, and industries are discharged into water sources, leading to widespread AMR. This is aggravated by poor separation of human waste depositions and potable drinking water sources in rural and informal settlements. Our UK-Africa partnership has recently identified the presence of high antibiotic residues and ARGs in wastewaters and drinking water in the region, underscoring the health risks to the population. The AMR burden not only threatens the health sector, but also prevents poor countries from investing in crucial areas like sanitation, education, food security, and infrastructure development, hindering the achievement of Sustainable Development Goal 3 (SDG 3) - Health and Human Wellbeing, and SDG 6 - Water and Sanitation. The proposed research aligns with these SDGs by delivering high-quality applied health research to meet the needs of people in Kenya and Uganda, which can be scaled up to benefit other LMICs in East Africa. The project will also continue to generate surveillance data on antibiotic use, pathogens on the World Health Organization (WHO) watch list, which will be made available for all LMICs through the digital AMR online hub. This will enhance the contribution of the East and South African regions in sharing AMR data with the WHO Global AMR and Use Surveillance System. At the hospital, county, national, and regional levels, this data can influence existing antibiotic policy needs and more rational use of antibiotics among patients and health practitioners.\n. This project has seven objectives:\n1. To investigate the influence of abiotic and biotic factors on antibiotics and antimicrobial resistance genes levels in aquatic environments.\n2. To co-design a surveillance and monitoring system to facilitate effective reduction strategies for antimicrobial resistance (AMR) in clinical, animals and environmental settings.\n3. To optimise an eco-hydro wetland to remove antibiotics, antimicrobial resistance genes and multidrug-resistant pathogens from wastewater in a cost-effective and sustainable way.\n4. To co-develop a digital AMR online hub for training, management and regulation of AMR.\n5. To estimate the economic cost of AMR.\n6. To co-design avenues of community engagement and involvement for reduction of AMR.\n7. To build human capacity for sustainable AMR research and management.\n \n ID: GB-GOV-10-GHRG_5_163709\nTitle: NIHR Global Health Research Group on A Test-and-Treat-All for prevention of Hepatitis B Virus mother-to-child transmission in Africa\nDescription: The STOP-HBV project (A Simplified Screen-and-Treat-All Prophylaxis Approach in Pregnant Women to Stop Hepatitis B Virus Mother-to-Child Transmission) is a multi-country research project funded by the UK Department for Health and Social Care (DHSC) through its National Institute for Health and Care Research (NIHR). The project aims to develop and evaluate a simplified strategy to prevent mother-to-child transmission (MTCT) of hepatitis B virus (HBV) in Malawi and The Gambia, where HBV prevalence remains high and access to screening and treatment during pregnancy is limited. \n\nSTOP-HBV addresses these challenges by evaluating a simplified “screen-and-treat-all prophylaxis” approach integrated within routine antenatal care services. The project combines clinical research, implementation science, and health systems strengthening to test whether simplified screening pathways and prophylactic antiviral treatment during pregnancy can reduce HBV transmission to infants born to HBV-positive mothers while remaining feasible and scalable in resource-limited settings. The research includes clinical cohort studies, health systems evaluation, community engagement, and policy-relevant implementation research.\n \nThe project will generate evidence on the clinical effectiveness, feasibility, cost-effectiveness, and acceptability of the proposed strategy, while also strengthening research capacity and collaborative networks between UK institutions and partner organisations in Africa. The project will be undertaken by Kamuzu University of Health Sciences Malawi, MRC Unit the Gambia, University of Liverpool UK and Canterbury Christ Church University UK in Malawi and The Gambia between March 2026 and February 2030.\n \nChronic HBV infection is a major global health challenge, particularly in low- and middle-income countries, where vertical transmission during pregnancy and childbirth is a key driver of lifelong infection. Infants infected at birth have a very high probability of developing chronic HBV infection, which substantially increases the risk of liver cirrhosis and hepatocellular carcinoma later in life. Despite the availability of effective prevention strategies, implementation barriers including limited diagnostics, complex treatment algorithms, and gaps in antenatal care continue to hinder effective prevention of mother-to-child transmission in many endemic settings. By producing actionable evidence for policymakers and national hepatitis programmes, STOP-HBV seeks to inform scalable strategies for eliminating HBV transmission at birth, contributing to the World Health Organization’s goal of eliminating viral hepatitis B as a public health threat by 2030.. This project has 8 objectives:\n1. Evaluate the effectiveness of a simplified screen-and-treat-all prophylaxis strategy during pregnancy to reduce mother-to-child transmission of hepatitis B virus (HBV) in endemic settings.\n2. Assess the feasibility and acceptability of integrating HBV screening and prophylactic treatment into routine antenatal care services in Malawi and The Gambia.\n3. Identify optimal screening strategies for detecting HBV infection among pregnant women in resource-limited healthcare systems.\n4. Determine the clinical outcomes of maternal antiviral prophylaxis, including safety for both mothers and infants and effectiveness in preventing vertical transmission.\n5. Evaluate implementation barriers and facilitators affecting the uptake and delivery of HBV prevention interventions within existing maternal health systems.\n 6. Assess the cost-effectiveness and scalability of simplified HBV prevention strategies to inform national and international hepatitis elimination policies.\n 7. Strengthen research capacity and collaborative networks between UK and African institutions through training, data sharing, and joint research activities.\n 8. Generate policy-relevant evidence to support the development of national and regional guidelines for preventing HBV mother-to-child transmission in low- and middle-income countries.\n \n ID: GB-GOV-10-GHRG_5_Reimbursements\nTitle: NIHR Global Health Research Groups: Call 5 Reimbursement Costs\nDescription: This activity captures the reimbursements made to seven applicants to Global Health Research Groups call 5. These applicants had received a letter signalling DHSC’s intend to fund their proposals but these offers were then retracted following the February 2025 announcement that UK Official Development Assistance (ODA) would reduce from 0.5% GNI to 0.3%. When DHSC notified recipients of this change, they were advised that reasonable costs incurred since receipt of \"intent to fund\" letters would be reimbursed, provided applicants could demonstrate these were directly related to the call and were ODA eligible. This was in appreciation of the significant time and energy invested in application and contracting stages, recognising that applicants may have begun work following assurances provided in the “intend to fund” letter.. \n", "_version_":1869205343324602368 }] } }