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"id":"e3468122-4870-4d94-8075-99dc893e50d5", "related_activity_context":"ID: GB-GOV-10-NIHR_GHRUG1\nTitle: NIHR Global Health Research Units and Groups: research call 1\nDescription: The NIHR's first Global Health Research call for Units and Groups. UK universities and research institutes were invited to submit applications, working in equitable partnerships with researchers in low- and middle-income countries (LMICs), to either expand (Units) or develop (Groups) their ambitions to deliver world-class applied global health research to address under-funded or under-researched global health areas specific to those countries.. 1) Deliver the UK's ambition to be internationally outstanding in global health research, improving the lives of people in LMICs. 2) Create an environment where world-class global health research, focused on the needs of LMICs can thrive. 3) Translate advances in applied global health research into benefits for patients and the public in LMICs. 4) Focus on priority areas which will have the greatest impact on health in LMICs in the short, medium and long term. 5) Provide high quality research evidence to inform decision-making by public health officials, practitioners and policy makers. 6) Increase the volume and quality of multi-disciplinary global health research from the UK. 7) Develop knowledge and capacity within existing UK institutions which can be translated into global health research practice. 8) Retain a level of responsive research capacity to address emerging global health research requirements (Units only).\n \n ID: GB-GOV-10-16_136_29\nTitle: NIHR Global Health Research Unit on Neglected Tropical Diseases\nDescription: A UK and low- and middle-income country (LMIC) partnership that aims to improve diagnosis, prevention, response and treatment of podoconiosis, mycetoma and scabies. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs. . 1) To improve the ability to diagnose, prevent and treat podoconiosis. 2) To develop tools to prevent mycetoma - there is no effective treatment. 3) To strengthen the ability of low-income countries to respond to scabies outbreaks.\n \n ID: GB-GOV-10-16_136_33\nTitle: NIHR Global Health Research Unit on Tackling Infections to Benefit Africa (TIBA)\nDescription: A UK and low- and middle-income country (LMIC) partnership that aims to reduce the burden of infectious diseases by strengthening health systems in Africa. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs.. 1) Improve the diagnosis and surveillance of infectious diseases in resource-poor settings. 2) Improve the deployment of existing drug treatments and enhance local capacity to develop new ones. 3) Improve the management of both endemic and emerging infections by strengthening health systems, with special attention to ethics and governance; improving policy development and implementation (e.g. drug procurement, local licensing, regulatory harmonization); and enhancing capacity to respond to infectious diseases emergencies, while protecting capacity to manage endemic diseases concurrently.\n \n ID: GB-GOV-10-16_136_35\nTitle: NIHR Global Health Research Unit on Lung Health and Tuberculosis in Africa \nDescription: A UK and low- and middle-income country (LMIC) partnership that aims to improve the health of children and adults through multi-disciplinary applied health research on lung health and tuberculosis, including non-communicable lung diseases and acute presentations of lung disease. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs.. 1) To focus their research efforts on improving lung health and fighting TB in Africa. 2) To support scientists and work to strengthen the research infrastructure of their institutions. 3) To conduct collaborative research to fill gaps in the current evidence base. For example, to explore ways to bring basic effective and affordable care to people living in both remote rural areas and expanding cities and slums. 4) To develop a 10 to 20 year strategy for Unit-led applied global health research in lung health and TB to look well beyond the initial funding with their sights set on delivering improvements in health for Africa's poorest populations.\n \n ID: GB-GOV-10-16_136_46\nTitle: NIHR Global Health Research Unit on Mucosal Pathogens (MPRU)\nDescription: A UK and low- and middle-income country (LMIC) partnership that aims to optimise control of mucosal pathogens causing pneumonia, meningitis and sepsis in young children. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs.. 1) Improved Diseases Intelligence: targeted surveillance of mucosal pathogens incorporating new molecular epidemiology, mathematical modelling and diagnostic tools to support vaccine evaluation, uptake and safety monitoring. 2) New Measures of Immunity: novel approaches to measuring protective immunity to determine how best to use new and existing vaccines; and determine how other non-vaccine interventions, such as harmless “commensal bacteria” will impact on disease. 3) Testing Interventions: as a prelude to large-scale trials, develop novel trial designs and feasibility studies of vaccine and other interventions. 4) Public Engagement: encourage a two-way dialogue with public and policymaker input into their thinking, ensuring that MPRU research is grounded in experience and needs of the public/policymakers. In collaboration with the NIHR Health Protection Research Unit (HPRU) in Immunisation, MPRU will support national/international policymaking through model development and research briefs. Public engagement will use websites, newsletters and social media; events involving policymakers, interest groups, schools and industry. \n \n ID: GB-GOV-10-16_136_54\nTitle: NIHR Global Health Research Unit on Health System Strengthening in Sub-Saharan Africa\nDescription: A UK and low- and middle-income country (LMIC) partnership that aims to work across primary care, maternal and surgical care platforms, to develop, adapt and evaluate health system strengthening interventions to enhance the processes and outcomes of evidence-based care. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs.. 1) Identify and evaluate system approaches to enhance guideline operationalisation; more explicit care pathways, manualised interventions, and technologies to improve detection/diagnosis (guideline optimisation). 2) Identify health system-strengthening needs for more effective delivery of GBC (health system assessment/diagnostic phase). 3) Develop and refine content and delivery of tailored health-system strengthening interventions (HSSI) with rigorous piloting and evaluation (development and piloting phase). 4) Evaluate the effects of scaling-up the resulting health system strengthening interventions (HSSI) package, on guideline-based care (GBC) processes and outcomes.\n \n ID: GB-GOV-10-16_136_68\nTitle: NIHR Global Health Research Unit on Diabetes and Cardiovascular Disease in South Asians\nDescription: A UK and low- and middle-income country (LMIC) partnership that aims to translate scientific discoveries and technological innovations into sustainable improvements in healthcare, to deliver improved prevention and better treatment of both diabetes and heart disease, amongst people from South Asia. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs. . 1) Strengthen disease surveillance for type-2 diabetes and cardiovascular disease to assess needs, priorities and performance. 2) Prioritise interventions for prevention, early detection and management of type-2 diabetes and cardiovascular disease, taking account of efficacy, scalability, sustainability and equity. 3) Develop capacity at Centres of Excellence, in regional Translational Research Networks, and through high-quality training. 4) Support frameworks for dissemination and implementation (policy, guidelines, pathways, standards) \n \n ID: GB-GOV-10-16_136_77\nTitle: NIHR Global Health Research Unit: Action on Salt China (ASC)\nDescription: A UK and low- and middle-income country (LMIC) partnership that aims to reduce salt intake amongst the poorest and most vulnerable populations through research and public health programmes. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs. . To develop and implement a comprehensive, effective and sustainable national salt reduction programme in China, through a series of programme, with special focus in rural areas to achieve a 30% reduction by 2025 as set by WHO. The programmes will include: 1) A health education programme to increase salt awareness; 2) a community/school-based education programme to encourage individuals to reduce salt during cooking; 3) a programme to work with restaurants to reduce salt in restaurant food; and 4) a programme to reduce salt in pre-packaged food by setting targets, improving labelling and providing tools to help consumers choose lower-salt food. Community and family-based strategies will be adopted in all activities with the support of traditional and innovative education and promotion technologies.\n \n ID: GB-GOV-10-16_136_79\nTitle: NIHR Global Health Research Unit on Global Surgery\nDescription: A UK and low- and middle-income country (LMIC) partnership that aims to develop context-appropriate global surgical research by establishing sustainable international research hubs and delivering practice-changing research for better patient outcomes. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs. . To create a sustainable platform where patients and surgeons from LMIC can identify priority areas, perform studies to find solutions, and find ways to bring these solutions to their patients. This will initially focus on surgery of the abdomen, but will cross over into other neglected areas of surgery, including women’s health and cancer treatment.\n \n ID: GB-GOV-10-16_136_87\nTitle: NIHR Global Health Research Unit on Improving Health in Slums\nDescription: A UK and low- and middle-income country (LMIC) partnership that aims to improve the health and welfare of people who live in slums. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs.. 1) To develop a partnership between the Liverpool School of Tropical Medicine (LSTM), African researchers in Uganda and Tanzania, health policy makers and programme managers, patient groups and community representatives and engage with other stakeholders to conduct research that has maximum immediate benefit on patient outcomes in Africa. 2) To develop and strengthen capacity in NCDs and in research methods, particularly in epidemiology, statistics, health economics and social science, both at LSTM and at our partner institutions in Africa. 3) To conduct early phase (pilot) studies and assess how diagnostic and treatment services for HIV infection, diabetes and hypertension should be integrated at health facilities, how these integrated services should be decentralised, how task-shifting should be organised and how patients should be supported and monitored.\n \n ID: GB-GOV-10-16_136_100\nTitle: NIHR Global Health Research Unit on Health in Situations of Fragility\nDescription: A UK and low- and middle-income country (LMIC) partnership that aims to analyse the challenges of delivering health services and promoting health in fragile situations, with the aim of identifying sources of resilience within formal health systems and local community mechanisms to facilitate effective provision for health priorities - particularly mental health and non-communicable disease - in situations of fragility. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs. . 1) to develop a systematic program of research identifying effective strategies to enhance the quality, accountability, coverage, and accessibility of priority health interventions through an integrated ‘systems for health’ approach to the growing burden of noncommunicable diseases (NCDs) and mental health. 2) to deploy cutting-edge methodologies for participatory health systems analysis and appraisal of community dynamics and resources to ensure that strategies to support intervention effectiveness are identified through rigorous analytical assessment. 3) to support development of a generalisable framework for fragility assessment as well as focused evidence regarding strategies to mitigate fragility for specific health interventions in localised settings.\n \n ID: GB-GOV-10-16_136_102\nTitle: NIHR Global Health Research Unit on Global Diabetes Outcomes\nDescription: A UK and low- and middle-income country (LMIC) partnership that aims to use innovative big data and mobile technologies to provide low-cost personalised medicine to combat ill health associated with diabetes. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs. . 1) To develop a large scale Scotland-India Clinical Partnership to combat diabetes. 2) To understand the heterogeneity of diabetes in India. 3) To develop innovative new tools and big data science to facilitate low-cost diabetes screening in India 4) To implement next generation precision telemedicine in India. \n \n ID: GB-GOV-10-16_136_109\nTitle: NIHR Global Health Research Unit on Respiratory Health (RESPIRE)\nDescription: A UK and low- and middle-income country (LMIC) partnership that aims to improve respiratory outcomes from common respiratory communicable and non-communicable disorders. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs.. 1) To build on their track-record of epidemiological research and capacity development in LMIC. 2) To invest in and strengthen our existing collaborations with leading research groups in South Asia. 3) To leverage their critical mass in respiratory, informatics and health services research, to expand efforts into the neglected field of applied respiratory research. 4) Build a network of laboratories and experts across strategically important countries from which to expand to similar local contexts elsewhere.\n \n ID: GB-GOV-10-16_136_111\nTitle: NIHR Global Health Research Unit on Genomic Surveillance of Antimicrobial Resistance\nDescription: A UK and low- and middle-income country (LMIC) partnership that aims to establish expertise and local research capacity in the use of whole genome sequencing in LMICs in order to provide intelligent global surveillance of microbial pathogens and antimicrobial resistance. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs. . 1) Develop capacity for locally-led research projects in LMICs and sampling frameworks to address national public health and research needs. 2) Provide actionable data at national and international levels to identify high-risk lineages of bacterial pathogens and determinants of antibiotic resistance, and open-access tools to understand their distribution and spread. 3) Provide resourcing and training for local capacity and expertise to ensure ownership of outputs and utility for action. 4) Build a network of laboratories and experts across strategically important countries from which to expand to similar local contexts elsewhere.\n \n ID: GB-GOV-10-16_137_16\nTitle: NIHR Global Health Research Group on Improving Stroke Care\nDescription: A UK and low- and middle-income country (LMIC) partnership that aims to improve stroke care in acute settings. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs.. NIHR Global Health Research Group on Improving Stroke Care objectives: 1) Create a partnership of clinicians, academics, patients and the public in India to develop research capacity to support innovation in healthcare in order to improve the management of stroke. 2) Develop effective ways of working together to prioritise, develop, deliver and implement research. 3) Engage with key stakeholders in healthcare in India to ensure that our research is relevant, important, accessible and practically focused. 4) Build sustainability for health research by supporting people and organisations to develop research, by building systems to facilitate research, and by capturing funding to support work to continue beyond the end of the project. 5) Identify key transferable knowledge for potential implementation in other settings and relevant health conditions.\n \n ID: GB-GOV-10-16_137_34\nTitle: NIHR Global Health Research Group on Diet and Activity\nDescription: A UK and low- and middle-income country (LMIC) partnership that aims to understand the determinants of population levels of diet and activity behaviour in LMICs and evaluate population-level interventions aimed at changing these behaviours in order to reduce the risk of non-communicable disease. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs.. 1) Generate evidence on the factors that lead to poor diet and physical inactivity in LMICs. 2) Design and evaluate interventions to change these factors (also known as determinants). 3) Use mathematical modelling to investigate the long-term health and economic effects of such interventions.\n \n ID: GB-GOV-10-16_137_44\nTitle: NIHR Global Health Research Group on Global Surgical Technologies\nDescription: A UK and low- and middle-income country (LMIC) partnership that aims to identify areas of surgical need and develop and evaluate new context-appropriate technological solutions. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs.. 1) Building on established academic and surgical networks and working with local ministries of health, NGOs, and private healthcare providers to conduct collaborative research. 2) Undertaking social science research to better understand local healthcare systems, including cultural and social attitudes to surgery, defining the unmet surgical needs, and assessing existing research strengths and capacity. 3) Using NIHR medical technology capability (Leeds NIHR Healthcare Technology Co-operative and Leeds Diagnostic Evaluation Centre) to develop disruptive, yet affordable, solutions to unmet surgical needs relevant to local healthcare settings. 4) Undertaking clinical evaluations, including cost-effectiveness assessment, in partnership with local researchers to inform wider adoption. 5) Establishing an advocacy programme, linked to other global health organisations, to influence awareness of health inequalities and promote the impact of our research.\n \n ID: GB-GOV-10-16_137_45\nTitle: NIHR Global Health Research Group on Post Conflict Trauma (PrOTeCT)\nDescription: A UK and low- and middle-income country (LMIC) partnership that aims to improve the health and wellbeing of civilians afflicted by blast injuries, reduce the socio-economic burden of explosive remnants of war in the developing world, develop a research and innovation hub for orthopaedic, trauma and biomaterials researchers, engineers and clinicians and advance understanding of biomaterials and orthopaedic technology. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs.. 1) Identify patient characteristics that have led to early avoidable amputation. 2) Provide immediate surgeon education for limb salvage/amputation using state of the art techniques. 3) Co-develop with our partners a biomaterial for bone that can be made locally, based on x-rays, and that will resorb over time. CAPACITY BUILDING: 1) Build a single research and translation team with surgeons, engineers and materials scientists co-located in both Sri Lanka and the UK, leveraging the expertise and caseload in Lebanon. 2) Strengthen the Biomedical Engineering programme at the University of Moratuwa (UoM) in Sri Lanka to include a Trauma stream with leadership from Dr Karunaratne. 3) Share unique and rare data and experiences to allow an improved understanding of civilian blast injury where global terror remains a threat to civilian populations. 4) Understand the healthcare burden post conflict to influence and enable overseas intervention.\n \n ID: GB-GOV-10-16_137_49\nTitle: NIHR Global Health Research Group on Nepal Injury Research\nDescription: A UK and low- and middle-income country (LMIC) partnership that aims to prevent injuries, make communities safer and improve injury outcomes in Nepal through collaborative research, surveillance, innovation, training, capacity building and policy development. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs.. 1) Engaging with stakeholders to understand their perspectives, awareness of the problem and priorities for change, and enable effective uptake of research. 2) Evidence through data will develop and pilot a hospital based injury surveillance system and explore the feasibility of collecting information on injuries from rural health posts. The Group will understand how injuries happened through interview, focus group, survey and verbal autopsy methods. 3) Effective and cost effective interventions will be developed and tested, adapting proven interventions from other LMICs where possible, and creating new interventions where necessary. Existing knowledge suggests that priority areas are likely to be road injuries, home injuries and the first response to trauma. 4) Enhancing capacity and enabling sustainability. Nepal has a limited and fragmented injury research capacity. The Group will establish partnerships to reduce isolation of researchers, and identify and meet their training needs to enable them to generate internationally excellent research. The Group will work with the Government of Nepal, academic institutions, NGOs and the WHO to plan the sustainability of the research centre in the long term.\n \n ID: GB-GOV-10-16_137_53\nTitle: NIHR Global Health Research Group on Stillbirth Prevention and Management in Sub-Saharan Africa\nDescription: A UK and low- and middle-income country (LMIC) partnership that aims to improve the prevention and management of stillbirth. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs.. 1) Prevention of stillbirth through improved identification of women with high risk pregnancies. We will explore how mother’s reporting of reduced baby movements during late pregnancy (a low cost method used widely in high income countries to alert clinicians to poor growth) could be adapted for use in LMIC settings. 2) Better childbirth care by examining factors which influence how women seek and access care, the quality of the care received and specific causes of stillbirth in local healthcare facilities, using new effective tools. 3) Ensuring humane and respectful care for bereaved parents through understanding the experiences of women, partners and health workers after stillbirth.\n \n ID: GB-GOV-10-16_137_62\nTitle: NIHR Global Health Research Group on Dementia Prevention and Enhanced Care (DePEC)\nDescription: A UK and low- and middle-income country (LMIC) partnership that aims to bring together expertise in public health and primary care with global epidemiological research to look at enhancing dementia prevention and care. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs.. 1) Create a new Global Research Group on dementia risk reduction and improved post-diagnostic care to map existing dementia research and care in partner LMIC. 2) Develop simple tools to identify people at high risk of developing dementia and those with undetected dementia. 3) Establish dementia risk reduction research in LMIC by setting up and piloting an intervention to reduce dementia risk. 4) Determine efficient and feasible dementia care models for LMICs and transferable educational initiatives for a skilled workforce. 5) Develop an impact strategy for each partner LMIC, including research priorities, service organisation and workforce development.\n \n ID: GB-GOV-10-16_137_85\nTitle: NIHR Global Health Research Group on Early Childhood Development for Peacebuilding\nDescription: A UK and low- and middle-income country (LMIC) partnership that aims to support the implementation and evaluation of early childhood development programmes and the potential to promote sustainable development and peacebuilding in LMICs affected by conflict. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs.. 1) To create a sustainable network of early childhood development (ECD) researchers and practitioners from six countries affected by conflict. 2) To share knowledge and expertise across participants of the network and build research capacity in country to support the development and robust evaluation of ECD programmes. 3) To build specialist research capacity at Centre for Evidence and Social Innovation (CESI) to undertake global health research in relation to ECD,through the support of Yale and NYU. 4) To support the evaluation of ECD pilot programmes in six LMIC partner count ries that are to be delivered through support from UNICEF. 5) Work with UNICEF and the wider global Early Childhood Peace Consortium (ECPC) to develop and implement effective advocacy strategies for ECD programmes within partner countries and internationally. 6) Develop and implement a strategy to generate external funding to sustain and grow the network beyond the current three-year funding window in alignment with ECPC.\n \n ID: GB-GOV-10-16_137_87\nTitle: NIHR Global Health Research Group on Prevention and Management of Non-Communicable Diseases and HIV-infection in Africa\nDescription: A UK and low- and middle-income country (LMIC) partnership that aims to evaluate integrated prevention and management of chronic conditions in Africa, focusing on the double burden of HIV-infection with diabetes and hypertension, and on research that is relevant for policy and practice. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs.. 1) To develop a partnership between the Liverpool School of Tropical Medicine (LSTM), African researchers in Uganda and Tanzania, health policy makers and programme managers, patient groups and community representatives and engage with other stakeholders to conduct research that has maximum immediate benefit on patient outcomes in Africa. 2) To develop and strengthen capacity in NCDs and in research methods, particularly in epidemiology, statistics, health economics and social science, both at LSTM and at our partner institutions in Africa. These skills are severely lacking and inhibiting research in chronic diseases. 3) To conduct early phase (pilot) studies and assess how diagnostic and treatment services for HIVinfection, diabetes and hypertension should be integrated at health facilities, how these integrated services should be decentralised, how task-shifting should be organised and how patients should be supported and monitored.\n \n ID: GB-GOV-10-16_137_90\nTitle: NIHR Global Health Research Group on Global Health Econometrics and Economics (GHE2)\nDescription: A UK and low- and middle-income country (LMIC) partnership that aims to address the evidence gap in population- and health system-level interventions by applying and developing methods to (1) estimate their average and distributional impact and (2) assess their value-for-money. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs.. 1) To employ state-of-the-art empirical methods applied to existing but under-exploited data sources to assess average population health impact and distributional effects, thereby establishing both whether interventions work overall and whether health outcomes of the poorest and most vulnerable improve more than those of the rich. 2) To complement the evaluation of the effectiveness of interventions with an assessment of the value-for-money they offer (economic evaluation), which constitutes a critical, and currently underdeveloped, link between evidence and decision-making in the context of budget constrained choices.\n \n ID: GB-GOV-10-16_137_95\nTitle: NIHR Global Health Research Group on Global Chronic Obstructive Pulmonary Disease (COPD) in Primary Care\nDescription: A UK and low- and middle-income country (LMIC) partnership that aims to foster research in primary care and communities to improve the diagnosis, management and prognosis of Chronic Obstructive Pulmonary Disease (COPD) patients in LMICs. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs.. 1) To strengthen local research capacity in the partner countries in community-based COPD research and generic population research methods. 2) To develop and test community-based and culturally-appropriate approaches for identifying undiagnosed COPD in low resource countries. 3) To adapt evidence-based behavioural approaches for management of COPD according to cultural needs and the local healthcare infrastructure, and assess the feasibility of their implementation. 4) To build a robust platform for future collaborative research within the partner countries and other similar settings.\n \n ID: GB-GOV-10-16_137_97\nTitle: NIHR Global Health Research Group on Developing Psycho-Social Interventions for Mental Health Care\nDescription: A UK and low- and middle-income country (LMIC) partnership that aims to Develop psycho-social interventions for people with severe mental illnesses, utilising existing resources in communities. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs.. 1) To explore alternative forms of care that utilise existing personal and social resources, which can be provided through trained lay people, volunteers, peers, and families. 2) To build up the capacity and local expertise to conduct such research in three LMICs: Bosnia-Herzegovina, Colombia and Uganda.\n \n ID: GB-GOV-10-16_137_99\nTitle: NIHR Global Health Research Group on Social Policy and Health Inequalities\nDescription: A UK and low- and middle-income country (LMIC) partnership that aims to improve population health by studying the social determinants of health and to further understanding of how social policy may reduce health inequalities globally. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs.. 1) Expand the research potential of the 100M cohort by adding further data: geographical information including an indicator of the deprivation of each person’s area of residence (created as part of this project) and data on non-communicable diseases from hospitals and other sources. 2) Evaluate the impact of specific policies (a welfare programme and a subsidised housing programme) on health and health inequalities. 3) Measure Brazil’s progress against the Sustainable Development Goals on non-communicable diseases for different social groups. 4) Build research capacity in the evaluation of public health programmes internationally through the development and delivery of a course. 5) Develop and maintain a strong relationship with stakeholders, including policy makers and practitioners, so that analyses and results are focused, useful, timely and accessible. This will maximise the opportunity for action to be taken as a result of this research and will lead to the joint production of future research.\n \n ID: GB-GOV-10-16_137_101\nTitle: NIHR Global Health Research Group on Warfarin Anticoagulation in Patients with Cardiovascular Disease in Sub-Saharan Africa\nDescription: A UK and low- and middle-income country (LMIC) partnership that aims to improve anticoagulation with warfarin - an important area of unmet medical need in LMICs - by developing context-appropriate dosing algorithms, and further improve anticoagulation quality by using novel technological advances. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs.. 1. Evaluate the quality of anticoagulant services in Cape Town and rural and urban Uganda. 2. Recruit patients currently on warfarin to identify clinical and other non-genetic factors associated with poor anticoagulation control. 3. Develop a warfarin clinical dosing algorithm. 4. Evaluate genes specific to the local African populations in Uganda and South Africa that can impact on anticoagulation control, and the development of a novel genetic dosing algorithm. 5. Initiate a study to implement the clinical dosing algorithm in the two sites. Objectives for new work packages are: \n1. Develop protocols and guidance documents for the bundle, according to SQUIRE guidelines\n(squirestatement.org) and attain necessary governance approvals; 2. Develop locally-appropriate training packages to ensure hospital staff are aware of the bundle aims to support adherence and educate patients; 3. Work with local patient groups to co-create tools to support adherence and educate patients; 4. Implement the bundle in hospitals (in Kampala & Cape Town) and their down-referral anticoagulation clinics; 5. Assess the clinical effectiveness and cost effectiveness of the bundle; 6. Assess staff and patient views on the bundle.\n \n ID: GB-GOV-10-16_137_105\nTitle: NIHR Global Health Research Group on Neurotrauma\nDescription: A UK and low- and middle-income country (LMIC) partnership that aims to advance global neurotrauma care and research in order to save lives, reduce disability and improve the quality of life for patients with traumatic brain injury. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs.. 1) Map the current landscape, understand the current systems and challenges in traumatic brain injury (TBI) clinical care and research in a range of LMIC (Colombia, Ethiopia, India, Indonesia, Malaysia, Myanmar, South Africa,Tanzania). 2) develop organisational and cost-effective solutions to the challenges faced in these areas. 3) establish clinical networks, research capacity, and pathways for the testing and implementation of the proposed solutions in the partner LMIC.\n \n ID: GB-GOV-10-16_137_107\nTitle: NIHR Global Health Research Group on Psychosis Outcomes: the Warwick­India-Canada (WIC) Network\nDescription: A UK and low- and middle-income country (LMIC) partnership that aims to improve outcomes of psychotic disorders, harnessing the potential of digital and mobile technologies. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs.. 1) Develop and evaluate evidence-informed psychosis interventions to make sustained health improvements for poorly-served vulnerable individuals. 2) Understand pathways of care to develop early detection strategies in India. 3) Create a dataset of well-characterised inception cohorts of FEP with ‘research readiness’ systems and processes. 4) Investigate clinical and cost-effectiveness of innovative community care models including digital and mobile applications. 5) Build capacity by providing a strong multidisciplinary research and training programme.\n \n ID: GB-GOV-10-16_137_109\nTitle: NIHR Global Health Research Group on Evidence to Policy Pathway to Immunisation in China (NIHR EPIC)\nDescription: A UK and low- and middle-income country (LMIC) partnership that aims to conduct applied vaccine research to help decision makers build a vaccination programme that ensures reliable, affordable, equitable and uninterrupted supply of vaccines to the poorest and most at-risk members of the population. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs.. NIHR Global Health Research Group on Evidence to Policy Pathway to Immunisation in China (NIHR EPIC) objectives: 1) Conduct research to inform vaccination policy in China, focused around three themes: (i) understanding the epidemiology and burden of vaccine-preventable diseases, (ii) understanding manufacturing capacity, public demand and confidence around vaccines, and (iii) modelling the health, economic and equity impact of vaccine strategies, particularly on vulnerable populations. 2) Use results in collaboration with key stakeholders to strengthen the evidence-to-policy pathway for immunisation in China (and eventually other countries). 3) Set up a cross-national and cross-sectoral collaboration between four British and Chinese public health and academic organisations: the London School of Hygiene and Tropical Medicine (LSHTM), Public Health England (PHE), Chinese Centre for Disease Control and Prevention (China CDC) and Fudan University (Fudan).\n \n ID: GB-GOV-10-16_137_110\nTitle: NIHR Global Health Research Group on Burn Trauma\nDescription: A UK and low- and middle-income country (LMIC) partnership that aims to transform the standard of burn care and prevention in some of the poorest regions of the world using a systems-based approach backed by implementation science. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs.. 1) Building robust partnerships with national and international academic departments, global institutions and clinical burns services. 2) Developing a portfolio of high quality evidence-based research to identify and address the key priorities in global burn injury, with particular focus on resource-poor settings. 3) Advocating for effective, evidence-based regional and national policies for burn prevention and treatment. 4) Working in partnership with key policy-makers, funders and philanthropists to increase resource allocation to tackle the ’forgotten global public crisis’ of burn injuries. 5) Utilising implementation science and knowledge to action theory to support the scaling up of proven interventions and promote their integration into national health strategies. 6) Creating a global hub for aspiring clinicians and researchers dedicated to global burn care to exchange ideas, share innovations and work in an inspiring and interdisciplinary environment.\n \n ID: GB-GOV-10-16_137_114\nTitle: NIHR Global Health Research Group on African Snakebite Research\nDescription: A UK and low- and middle-income country (LMIC) partnership that aims to establish self-sustaining regional hubs of snakebite expertise to support national and regional authorities design and implement systems to reduce snakebite deaths and disability. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs.. 1) Snakebite Rapid Diagnostic Test: with our Kenya partners and the Liverpool School of Tropical Medicine (LSTM)’s Research Centre for Drugs and Diagnosis, we will develop Africa’s first near-patient snakebite diagnostic kit. 2) Generation of Important New Research Data by: a) Conducting clinical pharmacological studies of systemic venom/anti-venom interactions. b) Conducting hospital and community surveys in each country to develop accurate estimates of snakebite burden and socio-economic impact. c) Utilising LSTM’s preclinical antivenom testing expertise to develop systems for rapid and costeffective antivenom efficacy testing, initially in Kenya. 3) Capacity-Strengthening Benefits: a) We will pilot and establish region-specific first aid, hospital and rehabilitation guidelines and clinical training. b) We will test, first in Kenya and then in Nigeria and Cameroon, the first Snakebite Emergency Response System - a smartphone app-activation of motorcycle ambulances to speed rural snakebite victims to hospital. This will inexpensively improve local health capacity and snakebite outcomes.\n \n ID: GB-GOV-10-16_137_122\nTitle: NIHR Global Health Research Group on Road Safety\nDescription: A UK and low- and middle-income country (LMIC) partnership that aims to reduce the number and severity of road accidents in LMICs through the underpinning philosophy of local solutions for local problems. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs.. 1) Capture the current situation in each LMIC through local data collection of the road transport system. 2) Develop solutions and countermeasures from a socio-technical systems-based perspective based on the local data. 3) Evaluate these solutions in simulated environments (a significant output of the project is establishing simulator facilities at each LMIC institution). 4) Disseminate findings at local and national levels in order to shape the interventions, policy and regulations to reduce road crashes and associated public health trauma.\n", "_version_":1876173826754084864 }] } }