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RIGHT funds cutting-edge interdisciplinary applied health research in key areas in low- and middle-income countries (LMICs) where a strategic and targeted investment can result in a transformative impact. \nRIGHT Call 3 supports equitable partnerships between LMIC and UK researchers to generate new research knowledge and evidence on interventions to improve outcomes for those affected by multimorbidity in ODA-eligible countries.\nUK universities and research institutes were invited to submit applications including a co-applicant or joint lead applicant from an LMIC relevant to the research proposal. Research must be focused on improving the health and welfare of people in LMICs. . The aims of NIHR RIGHT Call 3 are to:\n1. Deliver applied health research for the direct and primary benefit to the health and wealth of people living in ODA-eligible countries affected by multimorbidity\n2. Ensure that the research funded through this call strengthens capacity for research and knowledge exchange through development of equitable partnerships between researchers in the ODA-eligible countries and the UK\n3. Promote interdisciplinary approaches to working, by specifically encouraging applications necessitating expertise and activities associated with a broad range of health-science disciplines, including but not limited to: clinical, health economics, statistics, qualitative and social sciences.\n \n ID: GB-GOV-10-RIGHT_3_201708\nTitle: NIHR RIGHT3: Intervention to screen and treat multimorbidity in high-risk patients. \nDescription: A UK and low-and-middle-income-country (LMIC) research partnership that aims to design and test a system which identifies patients suffering from multiple diseases (multimorbidity) when they seek emergency care in hospitals in Malawi and Tanzania. This could improve early disease treatment (reducing death), and ensure better follow-up (preventing complications, disability, and hospital readmission). The research project is being implemented by Malawi Liverpool Wellcome Trust (Malawi), Kilimanjaro Christian Medical Centre (Tanzania) and Muhimbili University (Tanzania), in collaboration with Liverpool School of Tropical Medicine (UK), between 01-09-2021 and 31-12-2025.. 1. To confirm the prevalence of multimorbidity in patients attending acute hospital services in Malawi and Tanzania.\n2. To create a strategy to recognise and treat multimorbidity using point-of-care tests incorporated into the emergency care pathways in Malawi and Tanzania, maximising acceptability to patients and healthcare workers, and optimising the impact of available resources.\n3. To test the optimised emergency care pathway intervention with a primary outcome of hospital admission-free survival three months after hospital admission\n \n ID: GB-GOV-10-RIGHT_3_201773\nTitle: NIHR RIGHT3: The CONTROL programme - Cognitive therapy for depression in tuberculosis treatment.\nDescription: A UK and low-and-middle-income-country (LMIC) research partnership that aims to improve outcomes for depression and tuberculosis (TB) in Pakistan, Afghanistan, and the Afghan refugee population in Pakistan.\nTuberculosis (TB) is the 10th leading cause of death in the world. Pakistan ranks fifth and fourth in the world for having a high-burden of TB and MultiDrug Resistant Tuberculosis (MDR-TB), respectively. Afghanistan has an even worse TB situation due to ongoing conflict.\nIt is estimated that almost 49% of people receiving TB treatment may also have depression. Depression may be caused as a result of TB related stigma or the side effects of TB treatments. When these conditions co-exist they may raise the risk of TB reactivation, contribute to poor adherence to TB treatment and disease progression. Inadequate treatment adherence often results in drug resistant TB (MDR-TB), potentially leading to a public health crisis and health security threat.\nThrough four linked work packages the project team aims to develop, test and implement a brief intervention: CONTROL (Cognitive therapy for depression in tuberculosis treatment) to improve the mental health and adherence to TB treatment in people who have TB and MDR-TB in Pakistan and Afghanistan, and the refugee Afghan population in Pakistan.. The cognitive therapy for depression in tuberculosis treatment (CONTROL) programme of research has five objectives:\n1. To develop, and pilot test the CONTROL intervention with patient and public involvement and engagement (PPIE).\n2. To evaluate the effectiveness and cost-effectiveness of CONTROL versus Enhanced Treatment As Usual (ETAU) in improving depressive symptoms in people with TB and depression (TBD) and also enhance adherence with anti TB treatment (ATT).\n3. To examine the effects of implementing CONTROL on the TB control programme and the wider health system.\n4. To complete a process evaluation, refine the intervention, to identify barriers and facilitators for implementation and examine how the intervention can be scaled up in the health system.\n5. To enhance capacity for implementation research in multimorbidity associated with chronic infections in the region.\n\n \n ID: GB-GOV-10-RIGHT_3_201813\nTitle: NIHR RIGHT3: Multimorbidity of HIV and severe acute malnutrition in sub-Saharan Africa\nDescription: A UK and low-and-middle-income-country (LMIC) partnership that aims to improve the recovery of children with human immunodeficiency virus (HIV) infection and severe acute malnutrition (SAM) after they leave hospital by tackling underlying medical and social causes of ill-health. Two networks of researchers with expertise in child health, mental health, laboratory science, social science and health economics, based in southern Africa (Zimbabwe and Zambia) and east Africa (Kenya), together with partner institutions in the UK, USA and Netherlands, will come together to undertake this project between 01-09-2021 and 31-08-2025. The goal is to better understand why children with HIV and SAM have a higher risk of dying and a lower chance of long-term recovery compared to children with SAM alone. The partnership plans to develop packages of interventions to ensure that children with HIV and SAM can survive and thrive. . 1: To understand the ‘multimorbidity’ of with human immunodeficiency virus (HIV) and severe acute malnutrition (SAM).\n2: To develop packages of interventions that will help children with HIV and SAM to recover more effectively when they leave hospital. \n3: To conduct a clinical trial which compares the new treatments (singly or in combination) against the best current treatment which is therapeutic food, anti-HIV drugs and an antibiotic called cotrimoxazole. \n \n ID: GB-GOV-10-RIGHT_3_201816\nTitle: NIHR RIGHT3: Integrated, person-centred approaches to multimorbidity in South African primary care\nDescription: A UK and low- and middle-income country (LMIC) research partnership will identify the commonest patterns of multiple long-term conditions (MLTC-M) in South Africa where high burdens of communicable diseases (HIV, TB, COVID-19), non-communicable diseases and mental health problems are colliding and disproportionately affecting people of working age. This information will inform improvements to an existing primary care clinical guidance and training package called PACK (Practical Approach to Care Kit). ‘PACK Multiple Long-Term Conditions’ will include enhanced clinical guidance and patient/ household information for the care of people living with MLTC-M. Implementation strategies will be co-developed that address barriers to system change and patient/ household priorities and will be tested in two provinces of South Africa (KwaZulu-Natal and Western Cape). We will model the cost and impact of the programme if it were to be scaled country wide. This four-year project commencing in September 2021 is being led by Principal Investigators from King’s College London and the University of Cape Town and brings together an interdisciplinary team with extensive experience of working in South African healthcare and in over 20 other LMICs. New models of care for people living with multiple long-term conditions are urgently needed worldwide, as health systems look to reform to realise Universal Health Coverage in the time of a pandemic. This project aims to deliver streamlined care that allows contacts with health services to be optimised and capacitates people and those living in their households to assume greater agency for their long-term health and wellbeing.. The project’s overall aim is to produce evidence-based, scalable solutions for care, treatment and support systems for people living with multiple long-term conditions – multimorbidity (MLTC-M) in low- and middle-income countries (LMICs) to enhance their health and well-being. The project objectives are to:\n1. Generate evidence on the prevalence and commonest configurations of MLTC-M, its determinants, associated healthcare utilisation and outcomes.\n2. Systematically - and throughout the project - engage with people living with MLTC-M, communities and civil society partners to address their priorities for care.\n3. With the health system, patient and community stakeholders, co-produce clinical tools (guidance + support materials) to enable providers to deliver streamlined, evidence-informed care to people living with MLTC-M.\n4. With health system, patient and community stakeholders, co-produce optimised implementation strategies for people-centred health systems strengthening to support the successful integration of quality MLTC-M care into routine practice.\n5. Evaluate the effectiveness of a co-produced intervention comprising these tools and implementation strategies on detection, treatment and control of MLTC-M; patient wellbeing; provider competence to deliver effective person-centred care; and costs, in two provinces in South Africa.\n6. Estimate the health gain and cost-effectiveness that would result from implementation of this intervention country wide.\n \n ID: GB-GOV-10-RIGHT_3_PPDA\nTitle: Proposal and Partnership Development Awards (PPDA) for NIHR Research and Innovation for Global Health Transformation (RIGHT) call 3 Stage 2 applicants\nDescription: The purpose of Proposal and Partnership Development Awards (PPDA) funding is to improve the quality and likelihood of success of the projects funded through the NIHR Research and Innovation for Global Health Transformation (RIGHT) programme. Applicants that are successful at RIGHT Stage 1 and invited to submit a Stage 2 application are eligible for a PPDA, subject to satisfactory submission of a PPDA application. Not all Stage 2 applicants awarded a PPDA go on to secure RIGHT programme funding, therefore the details of PPDA recipients are not published. For RIGHT Call 3, PPDA were extended to 12 applicant organisations to support partnership development and the preparation of a RIGHT Stage 2 application.. Proposal and Partnership Development Awards (PPDA) provide funding of up to £10,000 for organisations applying to NIHR Research and Innovation for Global Health Transformation (RIGHT) programme funding to:\n1.\tSupport applicants to work collaboratively with all study partners to develop the stage 2 application\n2.\tEnhance partnerships across the proposed research collaboration\n3.\tInitiate preparation of study governance documentation (i.e. due diligence and finance assurance policies)\nPPDA funds must be spent between the notification of RIGHT stage 1 outcome and the submission of the RIGHT stage 2 application.\n", "_version_":1862856020240367616 }] } }