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call. RIGHT funds cutting-edge interdisciplinary applied health research in key areas in low- and middle-income countries (LMICs) where a strategic and targeted investment can result in a transformative impact. \nRIGHT Call 4 supports equitable partnerships between LMIC and UK researchers to generate new research knowledge and evidence to address the global burden of unintentional injuries (including but not limited to road traffic accidents, falls, burns and drowning, and urgent and emergency care).\nUK and LMIC-based universities and research institutes were invited to submit applications. Research must be focused on improving the health and welfare of people in LMICs. . The aims of NIHR RIGHT Call 4 are to:\n1. Deliver applied health research for the direct and primary benefit to the health and wealth of people living in ODA-eligible countries, with a focus on addressing the global burden of unintentional injuries and urgent and emergency care \n2. Ensure that the research funded through this call strengthens capacity for research and knowledge exchange through development of equitable partnerships between researchers in the ODA-eligible countries and the UK\n3. Promote interdisciplinary approaches to working, by specifically encouraging applications necessitating expertise and activities associated with a broad range of health-science disciplines, including but not limited to: clinical, health economics, statistics, qualitative and social sciences.\n \n ID: GB-GOV-10-RIGHT_4_203062\nTitle: NIHR RIGHT 4: A Communications platform to improve pre-hospital transport of injured people in Rwanda\nDescription: A UK and low-and-middle-income-country (LMIC) partnership that aims to improve the management of pre-hospital transport for injured people in\nRwanda. In Rwanda, injury causes 9% of deaths; 47% of these deaths happen before the patient has reached hospital. Similar to many LMICs, Rwanda experiences long delays in getting patients to a hospital which is suitable to treat their injuries, with all communication between patients, ambulances, and hospitals done using multiple phone-calls. In this project, we will develop and test Rwanda912, a novel electronic communication tool for use in ambulances in low resource settings. Rwanda912 uses an ambulance Destination Decision Support Algorithm (DDSA) which matches injured patients with the nearest hospital that can treat their injuries. It does this based on information from hospitals on availability of staff and equipment, and from the ambulance crew on patient status. In collaboration with the Rwandan Ministry of Health, Rwandan ambulance services, and local and international academics, this project will test whether Rwanda912 reduces time from injury to arrival at hospital and improves clinical outcomes such as death, length of stay in hospital, and need for an intensive care unit. Our study will be done in one urban and one rural setting. . The aim of the study is to improve the management of pre-hospital transport for injured people in Rwanda. The objectives of the study are as follows;\n1. Finalise development of Rwanda912’s Ambulance Destination Decision Support Algorithm (DDSA) and user interfaces. The Rwanda912 concept has been designed and the initial version approved for rapid development to give a testable prototype. The basic software foundations for this prototype has been developed in another grant, funded by the US National Institute of Health. In this NIHR grant, the prototype will be iteratively improved by repeated user testing until a final Rwanda912 product, that accurately matches patients with facilities, is ready for implementation.\n2. Develop training materials and train staff to use the Rwanda912 app. This will occur in 2 stages. The first stage is the rapid development of training materials. The second stage is the delivery of training and user testing.\n3. Do mock field-trials and roll out the intervention to ensure the app will work well under “real world” conditions, Rwanda912 will be tested under controlled conditions in the field during mock trauma scenarios using dummy patients (actors who will act\nout different injury scenarios) at different locations in the study sites. The complete pathway from calling for an ambulance to arriving at a facility will be tested.\n4. Testing the application in the real world. We will collect baseline data on time that injured patients take to get to hospital and other study outcomes (like death, length of stay in hospital, and admission to the intensive care unit) for a period of over one1 year, whilst objectives 1-3 are being completed. This data collection will be done in both the rural and urban site. We will compare outcomes from after deployment of Rwanda912 to those collected before deployment of Rwanda912. This comparison will show us whether Rwanda912 has improved outcomes.\n5. In addition to the outcomes mentioned above, we will also collect information which will help us to find out why Rwanda912 worked or didn’t work. These “implementation outcomes” will include costs, acceptability, and use of the Rwanda912 app.\n \n ID: GB-GOV-10-RIGHT_4_203082\nTitle: NIHR RIGHT 4: A programme for burns management and prevention in low-resource settings in Pakistan\nDescription: A UK and low-and-middle-income-country (LMIC) partnership to address burn management, treatment and prevention in low-resource settings in Pakistan.  Globally, burns are responsible for around 11 million injuries and 180 000 burn-related deaths yearly. Unfortunately, 9 of 10 burn injuries and deaths happen in low-and-middle-income countries (LMICs) such as Pakistan. One in three people admitted to hospitals with burn injuries die within three weeks, and survivors face serious lifelong physical, emotional and social problems.  Current preventive practice and treatment services in Pakistan are lacking for burns-related problems. Therefore, there is an urgent need to improve the quality of health services for burn victims and reduce the rate of burns in Pakistan. The project will be carried out in burn centres and community across Pakistan. . The project’s overall aim is to evaluate culturally adapted prevention and multidisciplinary care quality and rehabilitation programmes for burns that can be implemented across LMICs.\nThe projects objectives are;\n1. To understand lived experiences of burn survivors, families, and other stakeholders including the experience of care and impact of burns \n2. To work together with key stakeholders (such as burn survivors, family members) to adapt a culturally appropriate affordable burn rehabilitation programme \n3. To develop a national burn registry that will help to collect information on burn injuries and after-effects \n4. To carry out a small-scale study to assess whether the co-adapted burn rehabilitation programme is feasible and acceptable in Pakistan. This will help the research team to prepare themselves for a larger study particularly on the aspects around how best to recruit and retain burn survivors in the study.\n5. To determine clinical effectiveness of the burn rehabilitation programme. This will be evident from changes in number of deaths caused by burn injuries, number of burn survivors readmitted to hospitals and impact on burn survivors’ health-related of quality life \n6. To determine whether the proposed burn rehabilitation programme is effective/valuable in relation to its cost.\n7. To undertake social media campaigns to promote burn prevention and risk assessment in communities, workplaces, industries, and households, improve first aid and address burn related stigma \n8. To work with policy makers and parliamentarians to develop national guidelines for burns care and prevention in Pakistan \n9. To build the capacity and capability of researchers and health professionals both in research and clinical practice. \nThese activities are crucial to improve prevention and burn rehabilitation across the country after the end of the project. \n \n ID: GB-GOV-10-RIGHT_4_203140\nTitle: NIHR RIGHT 4: Preventing Deaths from Acute Poisoning in Low- and Middle-Income Countries\nDescription: A UK and low-and-middle-income-country (LMIC) research partnership that aims to prevent deaths from acute poisoning. The project team will work closely with the World Health Organization (WHO) to strengthen Poison Information Centres (PIC), develop global guidelines, and provide clinical/public health research training. Primary research will address two major global problems: methanol and occupational pesticide poisoning. Clinical research on novel methanol diagnostics will be performed in major hospitals in India and Bangladesh, while an anthropological study of pre-hospital treatment of pesticide poisoning will take place in Sri Lankan villages. This work is a collaboration between 17 professionals located in partner institutions in Bangladesh, Sri Lanka, India, Iran, South Africa, China, Australia, Denmark, Norway, and the UK. Capacity building for research and PIC development will be done in partnership with the Asia-Pacific Association of Medical Toxicology (APAMT) and the Middle-East and North Africa Clinical Toxicology Association (MENATOX). The work of this NIHR RIGHT4 award is essential because poisoning is a neglected problem that kills more than 300,000 people each year, many of them in LMICs. The WHO recognises the urgent need for better knowledge on how/where poisoning occurs, tools to diagnose or treat patients, and national standards/guidance. The Centre will directly address these issues.. To improve the clinical care of patients with acute poisoning in low-and-middle-income countries (LMICs) by:\n1) Testing the use and cost-effectiveness of a novel bed-side diagnostic method for methanol poisoning in two controlled clinical trials in India and Bangladeshi hospitals\n2)Addressing community acceptance of antidotes for pesticide poisoning that could be given after poisoning but before the patient reaches hospital\n\nTo expand LMIC research on acute poisoning and global Poison Information Centre (PIC) capacity, through providing training at annual international clinical toxicology congresses in the Asia-Pacific and Middle-East/North African regions.\n\nTo create a global network of LMIC research centres of excellence on acute poisoning by increasing research capacity at sites in India, Bangladesh, and Sri Lanka.\n\nDevelop international guidance for management of pesticide poisoning and methanol poisoning, in collaboration with the World Health Organization.\n\nOur overarching question is whether the individual research work programs, generation of international guidelines, and increase in research and PIC capacity, will result in substantially more patients receiving evidence-based treatment for poisoning across the world, especially in LMICs. For the two poisons we have highlighted (methanol, pesticides) primary research will develop new diagnostic and treatment options and deepen our understanding.\n \n ID: GB-GOV-10-RIGHT_4_203194\nTitle: NIHR RIGHT 4: HIPCARE - a cluster randomised controlled trial with embedded process evaluation\nDescription: A UK and low-and-middle-income-country (LMIC) partnership that aims to improve quality-of-life for hip fracture patients and to reduce healthcare costs in India, the Philippines, Sri Lanka, Thailand and Vietnam. \nOlder patients are particularly likely to break a bone (fracture) because of a fall from a standing height, as their bones are weakened by osteoporosis. These ‘fragility’ fractures have serious consequences; in the UK 25% of hip fracture patients die within a year and survivors have a reduction in their quality-of-life similar to having a stroke. Outcomes may be even worse in LMIC without the same level of healthcare resource. Asia is particularly affected by rapidly ageing populations. The number of hip fractures is expected to increase from 1,124,060 now to 2,563,488 in 2050. Associated healthcare cost may rise to US$15 billion. Improving care for patients with hip fracture is therefore a priority in this region. \nLooking after patients following a hip fracture requires healthcare workers from many different backgrounds to work together. These include surgeons, doctors specialising in looking after older patients, nurses and therapists, each with defined roles and responsibilities. In the UK, this team approach has reduced the number of patients dying and improved quality-of-life after hip fracture. It also reduced time spent in hospital and associated healthcare costs. \nThis study is about testing the benefits of such ‘multidisciplinary’ care in 5 LMIC in South Asia. To optimise the care, hospitals will receive a training package called HIPCARE. After refining the training materials to make HIPCARE specific to each country, we will do a large study to compare HIPCARE with usual care in 40 hospitals in LMIC in South Asia.. The main aim is to improve the quality of life of patients after they have broken their hip and to reduce healthcare costs in low-and-middle-income-countries (LMIC). The project will have two principal objectives: \n1. To prepare the HIPCARE training package for each different country taking into account their specific healthcare system. \n2. To run a study to compare the quality of life of hip fracture patients who have been treated in a hospital where the HIPCARE training package has been introduced with patients who have been treated in a hospital that follows its standard care. \nWithin the study, the following seven outcomes will be compared between patients treated in HIPCARE hospitals and patients treated in Standard Care hospitals. The outcomes will be measured up to 4 months after hip fracture surgery: \n1) Quality of Life \n2) Mortality rate \n3) Mobility Status \n4) The need of residential care \n5) Complication rate \n6) Healthcare and resource needs \n7) Cost effectiveness of the trial treatments \nThese comparisons will be made for each country individually as well as for all countries together. In addition, this study will create a long-lasting research collaboration and sustainable infrastructure that can be used to facilitate future service improvements in each LMIC.\n \n ID: GB-GOV-10-RIGHT_4_203216\nTitle: NIHR RIGHT 4: Drowning prevention for newly mobile infants under 2 years in Bangladesh\nDescription: A UK and low- and middle-income country (LMIC) research partnership to prevent drowning young children aged 1-2 in Bangladesh. The project is a collaboration between Bournemouth University, the Royal National Lifeboat Institute (RNLI), the University of the West of England, the University of Southampton (all in the UK), and the Center for Injury Prevention & Research Bangladesh. Using an inclusive, humancentred design approach to identify the solutions that are most acceptable to local communities, whose input will be central to the whole process.. Our interdisciplinary project aims to reduce the incidence of drowning in young children in the north and south of Bangladesh. The objectives of the project are; 1. Build skills needed by communities and our research partners in rural\nBangladesh, focusing on research capacity building around both public involvement in research and Human-Centred Design. 2. Explore existing supervision practice for newly mobile children and the social, cultural and environmental circumstances in which drowning occurs. Using social science research methods will help understand the failures of existing interventions (if any) and challenges of keeping young children safe from drowning; 3. Identify possible solutions to the prevention of drowning from literature and our explorative social science study. Engage stakeholders (including local community, government officials, designers, social scientists, drowning prevention experts, our international advisory group) to help prioritise a range of possible solutions; 4. Develop and create new solutions, using Human-Centred-Design principles and processes, co-designed with people in the local community; 5. Test the best solutions from the Human-Centred Design process in communities and evaluate them on use and maintenance, effectiveness, and ability to roll out the interventions across Bangladesh; 6. Share the findings and lessons learnt both locally with the communities involved in the research, nationally in Bangladesh with policy-makers and relevant civil servants, and internationally through academic papers and at conferences.\n \n ID: GB-GOV-10-RIGHT_4_PPDA\nTitle: Proposal and Partnership Development Awards (PPDA) for NIHR Research and Innovation for Global Health Transformation (RIGHT) call 4 Stage 2 applicants\nDescription: The purpose of Proposal and Partnership Development Awards (PPDA) funding is to improve the quality and likelihood of success of the projects funded through the NIHR Research and Innovation for Global Health Transformation (RIGHT) programme. Applicants that are successful at RIGHT Stage 1 and invited to submit a Stage 2 application are eligible for a PPDA, subject to satisfactory submission of a PPDA application. Not all Stage 2 applicants awarded a PPDA go on to secure RIGHT programme funding, therefore the details of PPDA recipients are not published. For RIGHT Call 4, PPDA were extended to 7 applicant organisations to support partnership development and the preparation of a RIGHT Stage 2 application.. Proposal and Partnership Development Awards (PPDA) provide funding of up to £10,000 for organisations applying to NIHR Research and Innovation for Global Health Transformation (RIGHT) programme funding to:\n1.\tSupport applicants to work collaboratively with all study partners to develop the stage 2 application\n2.\tEnhance partnerships across the proposed research collaboration\n3.\tInitiate preparation of study governance documentation (i.e. due diligence and finance assurance policies)\nPPDA funds must be spent between the notification of RIGHT stage 1 outcome and the submission of the RIGHT stage 2 application.\n", "_version_":1862856020294893568 }] } }