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"id":"0379588f-2b34-4786-84ad-a7ac2351b31d", "related_activity_context":"ID: GB-GOV-10-RIGHT_7\nTitle: NIHR Research on Interventions for Global Health Transformation: Call 7\nDescription: National Institute for Health and Care Research (NIHR)'s seventh Research on Interventions for Global Health Transformation (RIGHT) call. RIGHT funds cutting-edge interdisciplinary applied health research in key areas in low- and middle-income countries (LMICs) where a strategic and targeted investment can result in a transformative impact. \nRIGHT Call 7 supports equitable partnerships between researchers to generate new research knowledge and evidence on supporting research to develop and evaluate interventions for the early detection and management of metabolic risk factors for cardiovascular disease and stroke in ODA-eligible countries. \nUK and LMIC-based universities and research institutes were invited to submit applications. Research must be focused on improving the health and welfare of people in LMICs. . The aims of NIHR RIGHT Call 7 are to:\n1. Deliver applied health research for the direct and primary benefit to the health and wealth of people living in ODA-eligible countries, with a focus on research to develop and evaluate interventions for the early detection and management of metabolic risk factors for cardiovascular disease and stroke. \n2. Strengthen capacity for research and knowledge exchange through equitable partnerships between researchers and institutions involved in the research.\n3. Promote interdisciplinary approaches to working (including, but not limited to: clinical medicine, health economics, statistics, qualitative and social sciences), to ensure that research objectives can be delivered. \n4. Generate new research knowledge and evidence on interventions to improve health outcomes of people in LMICs.\n \n ID: GB-GOV-10-RIGHT_7_206968\nTitle: NIHR RIGHT 7: Cardiovascular disease risk reduction in sub–Saharan Africa (CARisSA)\nDescription: A UK and low- and middle-income country (LMIC) research partnership between the London School of Hygiene & Tropical Medicine and the Wellcome Trust Kenya Research Programme that aims to develop and evaluate a community-centred intervention for cardiovascular disease (CVD) risk reduction is proposed. This partnership, involving experts from the UK, Kenya, and The Gambia, focuses on addressing high CVD risks in sub-Saharan Africa (SSA), especially in regions where CVD management is challenging due to limited resources and complex health system barriers.\n\nCVD rates are high in SSA, with younger populations at risk due to untreated hypertension, high blood pressure and other risk factors. The research will take place in Kilifi County, Kenya, and Kiang West, The Gambia. These regions are selected due to their high CVD burden and existing research infrastructure support that facilitates effective data collection and carrying out the intervention implementation.\n\nCommencing in March 2025, this award aims to address significant gaps in CVD risk management by implementing cost-effective, affordable, evidence-based solutions that are sustainable within the local health systems. The long-term goal is to improve CVD outcomes and make it easier to expand and use the approach in other areas with similar facilitated scalability and adoption across similar high-burden regions in SSA.\n\nThe award involves the designing and testing of a tailored intervention that includes several components, such as task-sharing with community health workers, using digital health tools, providing combination therapy, and forming peer support groups to manage overall CVD risk in high-burden SSA areas.. The award has five objectives:\n\n1. Co-design a community-centered intervention for cardiovascular disease (CVD) risk reduction in sub-Saharan Africa. \n\n2. Evaluate the feasibility of implementing the co-designed intervention in real-world community and primary care settings.\n\n3. Conduct a cluster randomised trial to assess the effectiveness of the intervention on CVD risk factors and health outcomes.\n\n4. Evaluate the economic viability and sustainability of the community-centred intervention for cardiovascular disease risk reduction.\n\n5. Conduct a process evaluation to understand the factors influencing the success and scalability of the intervention.\n \n ID: GB-GOV-10-RIGHT_7_206976\nTitle: NIHR RIGHT 7: Community pharmacies managing hypertension in Bangladesh and Pakistan (COPE-BP)\nDescription: A UK and low- and middle-income country (LMIC) research partnership that aims to develop and evaluate a community pharmacy-based intervention to improve hypertension management among low-income urban residents in Bangladesh and Pakistan. By delivering hypertension care through community pharmacies, the team seeks to enhance access to care and reduce the risk of cardiovascular diseases (CVDs).\n\nCVDs are the leading cause of death globally, and hypertension is the most significant modifiable risk factor for CVDs. In Bangladesh and Pakistan, a high percentage of individuals with hypertension remain undiagnosed, untreated, or have uncontrolled blood pressure, particularly among low-income urban residents who face significant barriers to accessing healthcare. Community pharmacies are widely accessible and frequently used by these populations but are not fully integrated into formal healthcare systems. \n\nThe long-term aim of the award is to reduce premature deaths and disabilities caused by hypertension and associated CVDs in Bangladesh and Pakistan. This intervention will enable community pharmacists to provide hypertension care, including blood pressure monitoring, medication adherence support, health education, and referrals to primary care physicians.\n\nCommencing in March 2025, the award will map existing community pharmacies and engage with key stakeholders to understand the current practices and identify barriers and facilitators regarding the implementation of the intervention. The intervention will be tested via a feasibility study before undertaking a randomised control trial to assess the effectiveness and cost effectiveness of the intervention in reducing systolic blood pressure.. The award has nine objectives:\n1. Develop a context-specific intervention aimed at managing hypertension among low-income urban residents in Bangladesh and Pakistan through community pharmacies. \n2. Explore the feasibility of delivering the intervention and refine methods and procedures for a large-scale trial. \n3. Assess the effectiveness of the intervention in reducing systolic blood pressure among low-income urban residents aged 30 years and older with hypertension in Bangladesh and Pakistan. \n4. Conduct a comprehensive process evaluation to understand the implementation process of the intervention and how the health system and urban context in each site influence its effectiveness and sustainability. \n5. Develop a cost-effectiveness model for hypertension care and assess the long-term cost-effectiveness of the intervention, including the costs of scaling up and the value of investing in strategies to improve uptake. \n6. Enhance capacity in applied research, leadership, and community-based hypertension management among researchers, pharmacists, and healthcare professionals in Bangladesh and Pakistan. \n7. Establish Community Advisory Panels in each country to engage patients, families, and community members in the research process. \n8. Work with key stakeholders to translate our project findings into policy and practice and enact plans to sustain research and its impact.\n9. Disseminate the intervention findings through academic publications, policy briefs, workshops, print and social media, and community events. \n \n ID: GB-GOV-10-RIGHT_7_206987\nTitle: NIHR RIGHT 7: SMARThealth Caribbean, a community-led digitally aided support system for cardiovascular disease prevention\nDescription: A low- and middle-income country (LMIC) award led by The University of the West Indies which aims to develop a community-led digital support system for the primary prevention of cardiovascular disease in four Caribbean countries: Commonwealth of Dominica, Guyana, Jamaica and St Vincent and the Grenadines.\n\nDue to commence in March 2025, the five-year project intends to work with research partners in India (the George Insitute for Global Health), the UK (Imperial College London and the University of Glasgow) and Canada (McMaster University) to reduce the risk of developing future diabetes, high blood pressure, heart disease and stroke. This has the potential to benefit women, their families/households, and communities and to strengthen regional health systems. This will be done via the delivery of the SMARThealth platform intervention for screening and managing cardiovascular disease risk factors in mothers who develop gestational diabetes (diabetes during pregnancy) or hypertensive disorders of pregnancy (high blood pressure during pregnancy), and their families. . The project has four objectives:\n1. To improve women’s cardiometabolic health in the first twelve months after gestational diabetes (diabetes during pregnancy) or hypertensive disorders of pregnancy (high blood pressure during pregnancy).\n2. To diagnose and reduce risk for diabetes, high blood pressure, heart disease and stroke in other adult household members.\n3. To implement a community-based screening and prevention program leading to health systems strengthening for women and families after the six-week postnatal care period.\n4. To build community awareness and develop clinical and research capacity around improving cardiometabolic health in the Caribbean.\n \n ID: GB-GOV-10-RIGHT_7_206988\nTitle: NIHR RIGHT 7: Integrated, co-developed intervention for detection and management of cardiometabolic risk factors in older Indians (CARDIO-INDIA)\nDescription: A UK and low- and middle-income country (LMIC) research partnership led by University of Leicester (UoL) and the Centre for Chronic Disease Control (CCDC) in India which aims to co-create, implement, and evaluate a community and health system-based intervention to improve the early detection, treatment, and management of metabolic risk factors for cardiovascular diseases among older people in India. \n\nHeart disease and stroke cause the greatest number of deaths in India and are not always identified early enough. Older people are more at risk of these two conditions because they might not get enough physical activity, be overweight, or have high blood pressure or high cholesterol or diabetes. As such, they often face challenges in getting continued care and complying with treatment advice. The project team will work with older people, their caregivers and frontline health workers to design a contextually relevant innovative care package. \n\nCommencing in July 2025, the award will deliver four interlinked work packages which will be guided by the community engagement and involvement activities. The intervention package will consist of a decision support system to aid doctors in providing guideline recommended care, an assisted telemedicine platform to seek specialist consultation where necessary, and a patient-facing mobile application to promote self-management. \n. The award has four objectives:\n\n1. To conduct formative research to understand key challenges in the detection, treatment, and management of metabolic risk factors for cardiovascular diseases and co-create an intervention, engaging all relevant stakeholders (Work Package 1).\n\n2. To implement the intervention and evaluate its effectiveness and cost-effectiveness in improving patient-related clinical outcomes in comparison to current care pathways (Work Package 2).\n\n3. To understand the acceptability, barriers, facilitators to implementing the intervention for different stakeholders and at different health system levels (Work Package 3).\n\n4. If the intervention is found to be effective, a toolkit will be developed to facilitate it's adoption across India and other low- and middle-income countries (LMICs) (Work Package 4). \n\n \n ID: GB-GOV-10-RIGHT_7_207002\nTitle: NIHR RIGHT 7: A Low-Cost, Scalable Treatment Strategy for Improving Hypertension Control in Low- and Middle-Income Settings\nDescription: A UK and low- and middle-income country (LMIC) research partnership that aims to improve hypertension control in Nigeria and Sri Lanka.\n\nHypertension, or high blood pressure, is a major global challenge, especially in regions such as Africa and Asia. The conventional treatment approach involves starting with one medication, subsequently increasing the dose, or adding another medication, but this is considered an ineffective and inefficient approach.\n\nCommencing in March 2025, the proposed research aims to evaluate a new treatment strategy for managing hypertension, focusing on its effectiveness, safety, and cost-effectiveness compared to usual care. This includes assessing hypertension control rates, budget impact, and implementation feasibility in primary care settings. In turn, this works to improve healthcare providers' skills and confidence, increase access to quality care among vulnerable populations, and reduce health inequities. Additionally, the award outputs seek to influence policy, potentially integrating the strategy into national health policies and ensuring sustainable hypertension control practices within primary care settings in Nigeria and Sri Lanka.. The award has four objectives:\n\n1. Formative research: understand the context and refine and adapt the new treatment strategy.\n2. Evaluate the effectiveness and safety of the new treatment strategy.\n3. Evaluate the implementation of the new treatment strategy.\n4. Evaluate the budget impact and cost-effectiveness of the new treatment strategy.\n \n ID: GB-GOV-10-RIGHT_7_207031\nTitle: NIHR RIGHT 7: Co-creation of a national technology-enabled program for weight management in Thailand\nDescription: A UK and low- and middle-income country (LMIC) research partnership which aims to improve weight management in Thailand. Heart disease is the number one cause of death in Thailand and obesity is one of the main causes of heart disease.\n\nTechnology has the potential to improve the quality of weight management services at a low cost. However, research is needed to ensure that these features would be equally accessible and effective for various disadvantaged groups in Thailand. This award aims to understand whether weight management programs that use technology can be an economical way for Thailand’s government to help people to lose weight and lower their risk of heart disease. Specifically, this research will work to reduce the risk of heart disease for 250,000 people in Thailand each year, with the potential for other countries facing similar challenges to also benefit.\n\nCommencing in March 2025, this award will assess the current situation in Thailand to understand what issues are important for the weight management program to be effective before working with healthcare providers and overweight people to develop two weight management programs. These will involve technology at two different price points, making sure that they are appealing for the elderly, poor and those living in rural or remote areas. Both interventions will be tested via a large study involving 4,500 overweight people across 60 health centres in Thailand, comparing those who use the two programs with people who are only given some advice, before the cost-effectiveness of the programme and whether it offers Thai taxpayers value for money will be assessed.. The award has four objectives:\n1. Undertake context (behavioural, technological, and organisational) analysis to inform intervention development.\n2. Co-create technology-enabled interventions for two price points being considered by the Thai policy makers, and assess their acceptability to diverse socio-demographic groups.\n3. Evaluate the effectiveness of intervention using a cluster randomised trial.\n4. Conduct economic evaluation and develop service standards for the interventions.\n \n ID: GB-GOV-10-RIGHT_7_207046\nTitle: NIHR RIGHT 7: Community-based Research for Assessment, Detection and management of hypertension after pregnancy for LifetimE Benefit (CRADLE-B)\nDescription: A UK and low-and middle-income country (LMIC) research partnership between King’s College London and University of Zambia bringing together experts in maternal medicine, hypertensive disorders of pregnancy, nephrology, cardiology, midwifery, nursing, community engagement, public health, and nutrition, across Sierra Leone, South Africa and Zambia to support women with high blood pressure early after delivery.\n\nWomen who have high blood pressure during pregnancy are at higher risk of heart disease, kidney disease or stroke as they get older. Across the world, more women die from these diseases than from any other cause. Over three quarters of these deaths take place in sub-Saharan Africa. Our early research shows that the risks of developing high blood pressure after childbirth may be much higher in LMICs like Sierra Leone, Zambia and South Africa. Women have limited knowledge about the risks of ongoing raised blood pressure after pregnancy, and damage it can cause. They also struggle to access and trust care that is available.\n\nCommencing in March 2025, the award aims to provide accessible, trusted, acceptable and affordable quality care to lower blood pressure and prevent long-term harm which will work to improve women’s current and future health, including later pregnancies. \n\nThe award will work together with women, families, communities, healthcare providers and policy makers in three countries to understand day-to-day barriers and facilitators for accessing and providing quality postnatal care before using findings to design a new monitoring pathway of women with high blood pressure. Point-of-care tests will be used to check for kidney and heart damage, which will bolster understanding of how to best collect information, and the extent to which this disease is affecting target communities (teenage girls, women who have lost their babies and those with disabilities) to plan future care. \n. The award has four objectives:\n\n1. To work together with women, families, communities, healthcare providers and policy makers in Sierra Leone, South Africa and Zambia to understand day-to-day barriers and facilitators to access and provision of quality postnatal care, and to establish community partnerships. \n\n2. To undertake a study of women with raised blood pressure in a previous or current pregnancy to understand what proportion of women develop longer-term or ‘chronic’ raised blood pressure and related damage to their body organs, using bedside testing for heart and kidney function. \n\n3. To work together to develop and evaluate a new ‘community champion-led’ intervention in order to: improve women’s knowledge about high blood pressure care and long-term health risks; improve access to local care, for example, testing blood pressure during the first year after birth; improve trust in care through tailored community champion support for monitoring, healthy-living and taking blood pressure medicines and improve blood pressure and risk of damage to other organs.\n\n4. To support training and development of local future research leaders including in research methods, management and governance.\n\n \n ID: GB-GOV-10-RIGHT_7_PPDA\nTitle: Proposal and Partnership Development Awards (PPDA) for NIHR Research on Interventions for Global Health Transformation (RIGHT) call 7 Stage 2 applicants\nDescription: The purpose of Proposal and Partnership Development Awards (PPDA) funding is to improve the quality and likelihood of success of the projects funded through the NIHR Research on Interventions for Global Health Transformation (RIGHT) programme. Applicants that are successful at RIGHT Stage 1 and invited to submit a Stage 2 application are eligible for a PPDA, subject to satisfactory submission of a PPDA application. Not all Stage 2 applicants awarded a PPDA go on to secure RIGHT programme funding, therefore the details of PPDA recipients are not published. For RIGHT Call 7, PPDA were extended to 13 applicant organisations to support partnership development and the preparation of a RIGHT Stage 2 application.. Proposal and Partnership Development Awards (PPDA) provide funding of up to £10,000 for organisations applying to NIHR Research on Interventions for Global Health Transformation (RIGHT) programme funding to:\n1.\tSupport applicants to work collaboratively with all study partners to develop the stage 2 application\n2.\tEnhance partnerships across the proposed research collaboration\n3.\tInitiate preparation of study governance documentation (i.e. due diligence and finance assurance policies)\nPPDA funds must be spent between the notification of RIGHT stage 1 outcome and the submission of the RIGHT stage 2 application.\n", "_version_":1862221874815041536 }] } }