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      "last-updated-datetime":"2026-02-13T18:59:49Z",
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      "title.narrative":["Phase II polyvalent vaccine for freshwater catfish (Pangasius)","Vaccin polyvalent pour le poisson-chat d’eau douce (pangasius) – Phase II"],
      "title_narrative":["Phase II polyvalent vaccine for freshwater catfish (Pangasius)","Vaccin polyvalent pour le poisson-chat d’eau douce (pangasius) – Phase II"],
      "title_narrative_text":["Phase II polyvalent vaccine for freshwater catfish (Pangasius)","Vaccin polyvalent pour le poisson-chat d’eau douce (pangasius) – Phase II"],
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      "description.narrative":["Vietnam is the global market leader in producing farmed freshwater catfish species known as Pangasius. Production has intensified, reaching 1.5 million tonnes in 2021 with an estimated value of USD1.7 billion (CAD2.21B). However, intensification has increased the prevalence and transmission of infections, resulting in up to 90% fish mortalities within affected farms. Vaccine hesitancy remains high, with Vietnamese Pangasius farmers choosing to administer a cocktail of antibiotics. The over-use of antibiotics has contributed to a rapid increase in antimicrobial resistance (AMR), resulting in mass fish mortalities and subsequent treatment failures. This aquatic food production sector has reached an AMR crisis point and urgently needs an alternative to antibiotics. \n\nA whole-cell inactivated vaccine has been developed for freshwater catfish and administered by immersion to give greater than 70% protection against two major pathogens during vaccination and efficacy trials. This project will advance the proof-of-concept polyvalent immersion vaccine through the development pipeline, increase vaccine uptake and provide the Pangasius farmers with an attractive alternative to antibiotics that they are willing to use. This interdisciplinary project will adopt state-of-the-art methods to address vaccine hesitancy in the fish farming communities, determine duration and level of protection in the target fish species, and develop laboratory-based assays to monitor successful vaccination.\n\nThis project is funded under InnoVet-AMR 2.0, a four-year partnership between IDRC and the UK’s Department of Health and Social Care. The initiative is aimed at reducing the emerging risk that anti-microbial resistance (AMR) in animals poses to global health and food security. ","Le Vietnam est le leader mondial de la production de poissons-chats d’eau douce d’élevage, connus sous le nom de pangasius. La production s’est intensifiée, atteignant 1,5 million de tonnes en 2021 pour une valeur estimée à 1,7 milliard USD (2,21 milliards CAD). Cependant, l’intensification a augmenté la prévalence et la transmission des infections, entraînant une mortalité des poissons pouvant aller jusqu’à 90 % dans les exploitations touchées. Les petites exploitations de pangasius au Vietnam préfèrent administrer un cocktail d’antibiotiques. L’utilisation excessive d’antibiotiques a contribué à l’augmentation rapide de la résistance aux antimicrobiens (RAM), entraînant des mortalités massives de poissons et l’échec des traitements qui s’ensuivent. Ce secteur de la production alimentaire aquatique a atteint un point critique en matière de résistance aux antimicrobiens et a besoin de toute urgence d’une solution de rechange aux antibiotiques. \n\nUn vaccin inactivé à cellules entières a été mis au point pour le poisson-chat d’eau douce et administré par immersion pour conférer une protection supérieure à 70 % contre deux pathogènes majeurs au cours d’essais de vaccination et d’efficacité. Ce projet permettra de faire progresser le vaccin polyvalent par immersion, dont le concept a fait ses preuves, dans la filière de développement, d’augmenter l’utilisation du vaccin et de fournir aux petites exploitations de pangasius une solution de rechange attrayante aux antibiotiques qui sont habituellement utilisés. Ce projet interdisciplinaire adoptera des méthodes de pointe pour lutter contre l’hésitation des communautés piscicoles à utiliser le vaccin, pour déterminer la durée et le niveau de protection des espèces de poissons ciblées et pour mettre au point des essais en laboratoire permettant de contrôler la réussite de la vaccination.\n\nCe projet est financé dans le cadre de l’initiative Solutions vétérinaires innovatrices pour la résistance aux antimicrobiens 2.0 (InnoVet-AMR 2.0), un partenariat de quatre ans entre le CRDI et le Department of Health and Social Care du Royaume-Uni. L’initiative vise à réduire les risques émergents que pose la résistance aux antimicrobiens chez les animaux pour la santé mondiale et la sécurité alimentaire. "],
      "description_narrative":["Vietnam is the global market leader in producing farmed freshwater catfish species known as Pangasius. Production has intensified, reaching 1.5 million tonnes in 2021 with an estimated value of USD1.7 billion (CAD2.21B). However, intensification has increased the prevalence and transmission of infections, resulting in up to 90% fish mortalities within affected farms. Vaccine hesitancy remains high, with Vietnamese Pangasius farmers choosing to administer a cocktail of antibiotics. The over-use of antibiotics has contributed to a rapid increase in antimicrobial resistance (AMR), resulting in mass fish mortalities and subsequent treatment failures. This aquatic food production sector has reached an AMR crisis point and urgently needs an alternative to antibiotics. \n\nA whole-cell inactivated vaccine has been developed for freshwater catfish and administered by immersion to give greater than 70% protection against two major pathogens during vaccination and efficacy trials. This project will advance the proof-of-concept polyvalent immersion vaccine through the development pipeline, increase vaccine uptake and provide the Pangasius farmers with an attractive alternative to antibiotics that they are willing to use. This interdisciplinary project will adopt state-of-the-art methods to address vaccine hesitancy in the fish farming communities, determine duration and level of protection in the target fish species, and develop laboratory-based assays to monitor successful vaccination.\n\nThis project is funded under InnoVet-AMR 2.0, a four-year partnership between IDRC and the UK’s Department of Health and Social Care. The initiative is aimed at reducing the emerging risk that anti-microbial resistance (AMR) in animals poses to global health and food security. ","Le Vietnam est le leader mondial de la production de poissons-chats d’eau douce d’élevage, connus sous le nom de pangasius. La production s’est intensifiée, atteignant 1,5 million de tonnes en 2021 pour une valeur estimée à 1,7 milliard USD (2,21 milliards CAD). Cependant, l’intensification a augmenté la prévalence et la transmission des infections, entraînant une mortalité des poissons pouvant aller jusqu’à 90 % dans les exploitations touchées. Les petites exploitations de pangasius au Vietnam préfèrent administrer un cocktail d’antibiotiques. L’utilisation excessive d’antibiotiques a contribué à l’augmentation rapide de la résistance aux antimicrobiens (RAM), entraînant des mortalités massives de poissons et l’échec des traitements qui s’ensuivent. Ce secteur de la production alimentaire aquatique a atteint un point critique en matière de résistance aux antimicrobiens et a besoin de toute urgence d’une solution de rechange aux antibiotiques. \n\nUn vaccin inactivé à cellules entières a été mis au point pour le poisson-chat d’eau douce et administré par immersion pour conférer une protection supérieure à 70 % contre deux pathogènes majeurs au cours d’essais de vaccination et d’efficacité. Ce projet permettra de faire progresser le vaccin polyvalent par immersion, dont le concept a fait ses preuves, dans la filière de développement, d’augmenter l’utilisation du vaccin et de fournir aux petites exploitations de pangasius une solution de rechange attrayante aux antibiotiques qui sont habituellement utilisés. Ce projet interdisciplinaire adoptera des méthodes de pointe pour lutter contre l’hésitation des communautés piscicoles à utiliser le vaccin, pour déterminer la durée et le niveau de protection des espèces de poissons ciblées et pour mettre au point des essais en laboratoire permettant de contrôler la réussite de la vaccination.\n\nCe projet est financé dans le cadre de l’initiative Solutions vétérinaires innovatrices pour la résistance aux antimicrobiens 2.0 (InnoVet-AMR 2.0), un partenariat de quatre ans entre le CRDI et le Department of Health and Social Care du Royaume-Uni. L’initiative vise à réduire les risques émergents que pose la résistance aux antimicrobiens chez les animaux pour la santé mondiale et la sécurité alimentaire. "],
      "description_narrative_text":["Vietnam is the global market leader in producing farmed freshwater catfish species known as Pangasius. Production has intensified, reaching 1.5 million tonnes in 2021 with an estimated value of USD1.7 billion (CAD2.21B). However, intensification has increased the prevalence and transmission of infections, resulting in up to 90% fish mortalities within affected farms. Vaccine hesitancy remains high, with Vietnamese Pangasius farmers choosing to administer a cocktail of antibiotics. The over-use of antibiotics has contributed to a rapid increase in antimicrobial resistance (AMR), resulting in mass fish mortalities and subsequent treatment failures. This aquatic food production sector has reached an AMR crisis point and urgently needs an alternative to antibiotics. \n\nA whole-cell inactivated vaccine has been developed for freshwater catfish and administered by immersion to give greater than 70% protection against two major pathogens during vaccination and efficacy trials. This project will advance the proof-of-concept polyvalent immersion vaccine through the development pipeline, increase vaccine uptake and provide the Pangasius farmers with an attractive alternative to antibiotics that they are willing to use. This interdisciplinary project will adopt state-of-the-art methods to address vaccine hesitancy in the fish farming communities, determine duration and level of protection in the target fish species, and develop laboratory-based assays to monitor successful vaccination.\n\nThis project is funded under InnoVet-AMR 2.0, a four-year partnership between IDRC and the UK’s Department of Health and Social Care. The initiative is aimed at reducing the emerging risk that anti-microbial resistance (AMR) in animals poses to global health and food security. ","Le Vietnam est le leader mondial de la production de poissons-chats d’eau douce d’élevage, connus sous le nom de pangasius. La production s’est intensifiée, atteignant 1,5 million de tonnes en 2021 pour une valeur estimée à 1,7 milliard USD (2,21 milliards CAD). Cependant, l’intensification a augmenté la prévalence et la transmission des infections, entraînant une mortalité des poissons pouvant aller jusqu’à 90 % dans les exploitations touchées. Les petites exploitations de pangasius au Vietnam préfèrent administrer un cocktail d’antibiotiques. L’utilisation excessive d’antibiotiques a contribué à l’augmentation rapide de la résistance aux antimicrobiens (RAM), entraînant des mortalités massives de poissons et l’échec des traitements qui s’ensuivent. Ce secteur de la production alimentaire aquatique a atteint un point critique en matière de résistance aux antimicrobiens et a besoin de toute urgence d’une solution de rechange aux antibiotiques. \n\nUn vaccin inactivé à cellules entières a été mis au point pour le poisson-chat d’eau douce et administré par immersion pour conférer une protection supérieure à 70 % contre deux pathogènes majeurs au cours d’essais de vaccination et d’efficacité. Ce projet permettra de faire progresser le vaccin polyvalent par immersion, dont le concept a fait ses preuves, dans la filière de développement, d’augmenter l’utilisation du vaccin et de fournir aux petites exploitations de pangasius une solution de rechange attrayante aux antibiotiques qui sont habituellement utilisés. Ce projet interdisciplinaire adoptera des méthodes de pointe pour lutter contre l’hésitation des communautés piscicoles à utiliser le vaccin, pour déterminer la durée et le niveau de protection des espèces de poissons ciblées et pour mettre au point des essais en laboratoire permettant de contrôler la réussite de la vaccination.\n\nCe projet est financé dans le cadre de l’initiative Solutions vétérinaires innovatrices pour la résistance aux antimicrobiens 2.0 (InnoVet-AMR 2.0), un partenariat de quatre ans entre le CRDI et le Department of Health and Social Care du Royaume-Uni. L’initiative vise à réduire les risques émergents que pose la résistance aux antimicrobiens chez les animaux pour la santé mondiale et la sécurité alimentaire. "],
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      "related_activity_context":"ID: XM-DAC-301-2-110299-001\nTitle: Phase II polyvalent vaccine for freshwater catfish (Pangasius). Vaccin polyvalent pour le poisson-chat d’eau douce (pangasius) – Phase II\nDescription: Vietnam is the global market leader in producing farmed freshwater catfish species known as Pangasius. Production has intensified, reaching 1.5 million tonnes in 2021 with an estimated value of USD1.7 billion (CAD2.21B). However, intensification has increased the prevalence and transmission of infections, resulting in up to 90% fish mortalities within affected farms. Vaccine hesitancy remains high, with Vietnamese Pangasius farmers choosing to administer a cocktail of antibiotics. The over-use of antibiotics has contributed to a rapid increase in antimicrobial resistance (AMR), resulting in mass fish mortalities and subsequent treatment failures. This aquatic food production sector has reached an AMR crisis point and urgently needs an alternative to antibiotics. \n\nA whole-cell inactivated vaccine has been developed for freshwater catfish and administered by immersion to give greater than 70% protection against two major pathogens during vaccination and efficacy trials. This project will advance the proof-of-concept polyvalent immersion vaccine through the development pipeline, increase vaccine uptake and provide the Pangasius farmers with an attractive alternative to antibiotics that they are willing to use. This interdisciplinary project will adopt state-of-the-art methods to address vaccine hesitancy in the fish farming communities, determine duration and level of protection in the target fish species, and develop laboratory-based assays to monitor successful vaccination.\n\nThis project is funded under InnoVet-AMR 2.0, a four-year partnership between IDRC and the UK’s Department of Health and Social Care. The initiative is aimed at reducing the emerging risk that anti-microbial resistance (AMR) in animals poses to global health and food security. . Le Vietnam est le leader mondial de la production de poissons-chats d’eau douce d’élevage, connus sous le nom de pangasius. La production s’est intensifiée, atteignant 1,5 million de tonnes en 2021 pour une valeur estimée à 1,7 milliard USD (2,21 milliards CAD). Cependant, l’intensification a augmenté la prévalence et la transmission des infections, entraînant une mortalité des poissons pouvant aller jusqu’à 90 % dans les exploitations touchées. Les petites exploitations de pangasius au Vietnam préfèrent administrer un cocktail d’antibiotiques. L’utilisation excessive d’antibiotiques a contribué à l’augmentation rapide de la résistance aux antimicrobiens (RAM), entraînant des mortalités massives de poissons et l’échec des traitements qui s’ensuivent. Ce secteur de la production alimentaire aquatique a atteint un point critique en matière de résistance aux antimicrobiens et a besoin de toute urgence d’une solution de rechange aux antibiotiques. \n\nUn vaccin inactivé à cellules entières a été mis au point pour le poisson-chat d’eau douce et administré par immersion pour conférer une protection supérieure à 70 % contre deux pathogènes majeurs au cours d’essais de vaccination et d’efficacité. Ce projet permettra de faire progresser le vaccin polyvalent par immersion, dont le concept a fait ses preuves, dans la filière de développement, d’augmenter l’utilisation du vaccin et de fournir aux petites exploitations de pangasius une solution de rechange attrayante aux antibiotiques qui sont habituellement utilisés. Ce projet interdisciplinaire adoptera des méthodes de pointe pour lutter contre l’hésitation des communautés piscicoles à utiliser le vaccin, pour déterminer la durée et le niveau de protection des espèces de poissons ciblées et pour mettre au point des essais en laboratoire permettant de contrôler la réussite de la vaccination.\n\nCe projet est financé dans le cadre de l’initiative Solutions vétérinaires innovatrices pour la résistance aux antimicrobiens 2.0 (InnoVet-AMR 2.0), un partenariat de quatre ans entre le CRDI et le Department of Health and Social Care du Royaume-Uni. L’initiative vise à réduire les risques émergents que pose la résistance aux antimicrobiens chez les animaux pour la santé mondiale et la sécurité alimentaire. \n \n ID: XM-DAC-301-2-110299-003\nTitle: Phase II polyvalent vaccine for freshwater catfish (Pangasius). Vaccin polyvalent pour le poisson-chat d’eau douce (pangasius) – Phase II\nDescription: Vietnam is the global market leader in producing farmed freshwater catfish species known as Pangasius. Production has intensified, reaching 1.5 million tonnes in 2021 with an estimated value of USD1.7 billion (CAD2.21B). However, intensification has increased the prevalence and transmission of infections, resulting in up to 90% fish mortalities within affected farms. Vaccine hesitancy remains high, with Vietnamese Pangasius farmers choosing to administer a cocktail of antibiotics. The over-use of antibiotics has contributed to a rapid increase in antimicrobial resistance (AMR), resulting in mass fish mortalities and subsequent treatment failures. This aquatic food production sector has reached an AMR crisis point and urgently needs an alternative to antibiotics. \n\nA whole-cell inactivated vaccine has been developed for freshwater catfish and administered by immersion to give greater than 70% protection against two major pathogens during vaccination and efficacy trials. This project will advance the proof-of-concept polyvalent immersion vaccine through the development pipeline, increase vaccine uptake and provide the Pangasius farmers with an attractive alternative to antibiotics that they are willing to use. This interdisciplinary project will adopt state-of-the-art methods to address vaccine hesitancy in the fish farming communities, determine duration and level of protection in the target fish species, and develop laboratory-based assays to monitor successful vaccination.\n\nThis project is funded under InnoVet-AMR 2.0, a four-year partnership between IDRC and the UK’s Department of Health and Social Care. The initiative is aimed at reducing the emerging risk that anti-microbial resistance (AMR) in animals poses to global health and food security. . Le Vietnam est le leader mondial de la production de poissons-chats d’eau douce d’élevage, connus sous le nom de pangasius. La production s’est intensifiée, atteignant 1,5 million de tonnes en 2021 pour une valeur estimée à 1,7 milliard USD (2,21 milliards CAD). Cependant, l’intensification a augmenté la prévalence et la transmission des infections, entraînant une mortalité des poissons pouvant aller jusqu’à 90 % dans les exploitations touchées. Les petites exploitations de pangasius au Vietnam préfèrent administrer un cocktail d’antibiotiques. L’utilisation excessive d’antibiotiques a contribué à l’augmentation rapide de la résistance aux antimicrobiens (RAM), entraînant des mortalités massives de poissons et l’échec des traitements qui s’ensuivent. Ce secteur de la production alimentaire aquatique a atteint un point critique en matière de résistance aux antimicrobiens et a besoin de toute urgence d’une solution de rechange aux antibiotiques. \n\nUn vaccin inactivé à cellules entières a été mis au point pour le poisson-chat d’eau douce et administré par immersion pour conférer une protection supérieure à 70 % contre deux pathogènes majeurs au cours d’essais de vaccination et d’efficacité. Ce projet permettra de faire progresser le vaccin polyvalent par immersion, dont le concept a fait ses preuves, dans la filière de développement, d’augmenter l’utilisation du vaccin et de fournir aux petites exploitations de pangasius une solution de rechange attrayante aux antibiotiques qui sont habituellement utilisés. Ce projet interdisciplinaire adoptera des méthodes de pointe pour lutter contre l’hésitation des communautés piscicoles à utiliser le vaccin, pour déterminer la durée et le niveau de protection des espèces de poissons ciblées et pour mettre au point des essais en laboratoire permettant de contrôler la réussite de la vaccination.\n\nCe projet est financé dans le cadre de l’initiative Solutions vétérinaires innovatrices pour la résistance aux antimicrobiens 2.0 (InnoVet-AMR 2.0), un partenariat de quatre ans entre le CRDI et le Department of Health and Social Care du Royaume-Uni. L’initiative vise à réduire les risques émergents que pose la résistance aux antimicrobiens chez les animaux pour la santé mondiale et la sécurité alimentaire. \n",
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