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We therefore need to better understand the key factors at the community level that promote restraint and de-escalation in violent environments. Former studies show the value of understanding how a culture of restraint is socialised within a community. However, not much is known about the role that communities play in influencing the behaviour of armed groups. Current approaches to humanitarian protection are rooted in formalised legalistic approaches. However, these approaches have limits in contexts where global humanitarian norms are contested or ignored on the ground. A new bottom-up approach to humanitarian protection is needed and this research seeks to identify successful examples of local protection measures and generate methods for communicating these to similar communities experiencing violence and to aid agencies.\n\nThis project will work in the Democratic Republic of the Congo (DRC), where human rights abuses are widespread, including extremely high levels of sexual violence. Whilst the resolution of the conflict on a national and regional level is clearly the long-term solution, in the meantime aid agencies, local religious institutions and civil society groups struggle to protect civilians. This research aims to provide new understandings and tools to both communities and aid providers to reinforce protective measures. By identifying where such local measures have worked, and under what circumstances, the research will provide an evidence base for policy and practice.\nOur consortium is formed of the Institute of Development Studies; two partner organisations in DRC - the Centre d'etude et de promotion en interventions socio-economiques (CEPRISE) and Institut National des Arts (INA); and Action Aid. We are ideally placed to undertake this research, bringing together deep experience of participatory methods, indigenous knowledge, gender and bottom-up approaches to humanitarianism, with storytelling through drama, music and literature.\n\nThrough identifying, locating, documenting and understanding where local protective measures have worked; we aim to help aid agencies and policy makers find appropriate ways to support these efforts and possibly find ways to replicate them. Our objectives are:\n\n1. To generate evidence on whether local, community-based protection measures work, and in what circumstances.\n2. To generate evidence on whether local, community-based measures to prevent or reduce sexual violence work and in what circumstances.\n3. To generate evidence on differing local and community-based attitudes to victims of sexual violence, and under what circumstances these allow for rehabilitation.\n4. To develop innovative local communication methods for transferring knowledge of successful protective measures.\n5. To generate programmatic lessons for aid agencies so that they can adapt protection programmes to support local measures.\n6. To generate policy lessons for aid agencies such that systemic approaches to protection can incorporate and support local action.\n\nThis research aims to have conceptual impact and provide new understandings and tools to both communities and aid providers to reinforce protective measures. 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It can damage the red blood cells and cause anaemia in individuals who carry a very common genetic abnormality deficiency of an enzyme called glucose-6-phosphate dehydrogenase, G6PD for short. This deficiency is much more common in men because of the way it is inherited. This is called haemolysis. This is a real downside of primaquine, though this problem has mainly been seen when primaquine is given in high doses for many days. However, for its 'transmission blocking' effects on the malaria parasite only a single, low dose of primaquine is thought to be required. This is considered by most experts to be too little primaquine to cause a major problem with haemolysis. Despite this many malaria control programmes are unwilling to use primaquine because they consider it too dangerous. You can test for G6PD deficiency but this requires test kits and staff to administer them. Many countries cannot afford to test millions of malaria patients before giving primaquine. In 2012 the World Health Organization (WHO) concluded on the basis of the available evidence and expert opinion that single low dose primaquine was safe to use even in malaria patients with G6PD deficiency. However the WHO also called for more research. Four years later virtually no one is using low dose primaquine because that research has not been done. If we can show beyond doubt that low dose primaquine is safe in G6PD deficient children with malaria, malaria programmes would feel much happier giving it and we could then go to the drug companies and ask them to make primaquine that is suitable for children. To see if single low dose primaquine is as safe as experts think we plan to study over 1,500 children with malaria attending outpatients in two hospitals in Uganda and one in the Democratic Republic of the Congo. Using a simple test for G6PD deficiency we will find 750 children with malaria who have G6PD deficiency, and 750 who have normal G6PD levels. Within these two groups we will, on a random basis, give half of the patients normal antimalarial treatment and the other half normal antimalarial treatment PLUS single low dose primaquine. We will then watch the children very carefully to see whether giving primaquine causes more anaemia than not giving primaquine, and whether this occurs particularly in the G6PD deficient group. We need to have comparison groups of children who do not receive primaquine and some children who do not have G6PD deficiency as malaria itself causes haemolysis, as can G6PD deficiency in some circumstances even without primaquine treat. Our aim is to unpick the effects of G6PD deficiency, malaria, and primaquine administration to really be sure whether in all circumstances giving low dose primaquine is safe. 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