{ "responseHeader":{ "status":0, "QTime":1, "params":{ "q":"recipient_country_code:CN AND reporting_org_ref:GB-GOV-* AND hierarchy:1", "fl":"default_lang,default_currency,humanitarian,hierarchy,iati_identifier,reporting_org_ref,reporting_org_type_code,reporting_org_secondary_reporter,reporting_org_narrative,title_narrative,description_narrative,participating_org_ref,participating_org_type,participating_org_role,participating_org_narrative,other_identifier_ref,other_identifier_owner_org_ref,other_identifier_owner_org_narrative,activity_status_code,activity_date_iso_date,activity_date_type,contact_info_organisation_narrative,contact_info_department_narrative,contact_info_person_name_narrative,contact_info_job_title_narrative,contact_info_telephone,contact_info_email,contact_info_website,contact_info_mailing_address_narrative,activity_scope_code,recipient_country_code_position,recipient_country_code,recipient_country_percentage,recipient_region_code,recipient_region_percentage,location_ref,location_id_code,location_id_vocabulary,location_reach_code,location_name_narrative,location_description_narrative,location_activity_description_narrative,location_administrative_vocabulary,location_administrative_code,location_administrative_level,location_point_pos,location_exactness_code,location_class_code,location_feature_designation_code,sector_vocabulary,sector_code,sector_percentage,tag_code,tag_vocabulary,tag_narrative,country_budget_items_vocabulary,country_budget_items_budget_item_code,country_budget_items_budget_item_percentage,country_budget_items_budget_description_narrative,country_budget_items_budget_description_narrative_lang,country_budget_items_budget_description_narrative_text,humanitarian_scope_type,humanitarian_scope_vocabulary,humanitarian_scope_code,humanitarian_scope_narrative,policy_marker_vocabulary,policy_marker_code,policy_marker_significance,collaboration_type_code,default_flow_type_code,default_finance_type_code,default_aid_type_code,default_aid_type_vocabulary,default_tied_status_code,budget_type,budget_status,budget_period_start_iso_date,budget_period_end_iso_date,budget_value_currency,budget_value_currency,budget_value,planned_disbursement_type,planned_disbursement_period_start_iso_date,planned_disbursement_period_end_iso_date,planned_disbursement_value,planned_disbursement_value_date,planned_disbursement_value,planned_disbursement_value_usd,planned_disbursement_provider_org_provider_activity_id,planned_disbursement_provider_org_type,planned_disbursement_provider_org_ref,planned_disbursement_provider_org_narrative,planned_disbursement_provider_org_narrative_lang,planned_disbursement_provider_org_narrative_text,capital_spend_percentage,transaction_ref,transaction_humanitarian,transaction_type,transaction_date_iso_date,transaction_value_currency,transaction_value_date,transaction_value,transaction_value_usd,transaction_provider_org_provider_activity_id,transaction_provider_org_type,transaction_provider_org_ref,transaction_provider_org_narrative,transaction_provider_org_narrative_lang,transaction_provider_org_narrative_text,transaction_disburstment_channel_code,transaction_sector_vocabulary,transaction_sector_vocabulary_uri,transaction_sector_code,transaction_recipient_country_code,transaction_recipient_region_code,transaction_recipient_region_vocabulary,transaction_flow_type_code,transaction_finance_type_code,transaction_aid_type_code,transaction_aid_type_vocabulary,transaction_tied_status_code,document_link_format,document_link_url,document_link_title_narrative,document_link_category_code,document_link_document_date_iso_date,related_activity_ref,related_activity_type,legacy_data_name,legacy_data_value,legacy_data_iati_equivalent,conditions_attached,conditions_condition_type,conditions_condition_narrative,result_type,result_aggregation_status,result_title_narrative,result_description_narrative,result_document_link_*,result_reference_*,result_indicator_*,crs_add_*,fss_*", "format":"json" } }, "response":{ "numFound":572, "start":0, "numFoundExact":true, "docs":[{ "default_currency":"GBP", "default_lang":"en", "iati_identifier":"GB-GOV-13-FUND--GCRF-MR_T016124_1", "reporting_org_ref":"GB-GOV-13", "reporting_org_type_code":"10", "reporting_org_narrative":["DEPARTMENT FOR BUSINESS, ENERGY & INDUSTRIAL STRATEGY"], "title_narrative":["Evaluating multiple loci modulating susceptibility of African malaria parasites to artemisinin"], "description_narrative":["Combination drugs for treatment of malaria deployed globally since the start of the 21st century have provided a substantial public health benefit. Malaria deaths across Africa in particular have plummeted since a peak in the 1990s, when failure of the drugs chloroquine and sulphadoxine-pyrimethamine precipitated a rise in infant and child deaths. A key component in all the currently effective drug combinations is the plant-derived chemical called artemisinin. The parasite-killing ability of artemisinin has recently been threatened by the emergence of reduced susceptibility in the Mekong region: this is manifest as a slowing of artemisinin clearance of P. falciparum from the blood of treated malaria patients. Although under combination treatments these patients should eventually experience a full cure in most cases, in this region the combination partner drugs are also failing in some patients. Careful monitoring and vigilance of malaria drug resistance is therefore needed. A parasite gene has been identified in Cambodia and the surrounding region which contributes to the loss of effectiveness of the artemisinin drug - this gene, which encodes a kelch-domain protein and is called K13, has accumulated a variety of mutations. These are strongly associated with the loss of effectiveness of artemisinin against these parasites. However, this same phenomenon has not yet been observed in African malaria parasites - in the small number of cases where drug treatment does not work, K13 mutations are not implicated as the cause. In the past 2 years, gene-editing studies by ourselves and others have successfully demonstrated a direct effect of 3 genes in reducing susceptibility to artemisinin : pfap2mu, pfubp1 and pfcoronin. Variants of these genes elicit increased parasite survival in vitro in the ring-stage artemisinin survival assay (RSA). In the case of trafficking adaptor potein subunit AP-2mu, we have shown that the role of this protein in P. falciparum is unlike in other organisms as it does not interact with clathrin, but is associated with an as yet unknown compartment in the cell that appears to also contain K13, although we found no evidence of direct interaction between AP-2mu and the K13 protein. There is, however, good evidence of direct interaction of AP-2mu with a different kelch protein , K10. Polymorphisms in the gene encoding the K10 protein have been previously identified as a genetic component of parasites from the Mekong region in which the K13-dependent reduced artemisinin susceptibility originally arose. This work was carried out by PhD student Ryan Henrici, who completed his doctoral studies in 2018 and has moved on. We now request support to extend this work, using gene editing to test the effect of new mutations. In preliminary studies of both field samples and UK isolates, we have already identified a number of such new mutations in our current five genes of interest - pfk13, pfap2mu, pfubp1, pfcoronin and pfk10 (see Case for Support). For each new isolate (either from the UK or from our collaborator Dr Bismarck Dinko in Ho, Ghana) that is adapted to culture, we will fully test drug susceptibility, and genetically characterise them using genome sequencing. In gene-editing experiments we will then directly measure the impact of each candidate gene variant in both established laboratory lines and in our new cultures from UK and Ghanaian patients; any variant proven to generate a drug susceptibility phenotype may therefore be contributing to changing patterns of drug susceptibility, and could be developed as a surveillance marker for use in malaria endemic areas. Our work will thus assist our understanding of resistance to our current combination drugs, and help us to devise strategies for deploying these drugs carefully in both the UK and Africa, to maximise their useful life in curing malaria patients.","The Global Challenges Research Fund (GCRF) supports cutting-edge research to address challenges faced by developing countries. The fund addresses the UN sustainable development goals. It aims to maximise the impact of research and innovation to improve lives and opportunity in the developing world."], "participating_org_ref":["GB-GOV-13","GB-COH-RC000346","GB-COH-RC000346"], "participating_org_role":["1","2","3"], "participating_org_type":["10","15","15"], "participating_org_narrative":["DEPARTMENT FOR BUSINESS, ENERGY & INDUSTRIAL STRATEGY","MEDICAL RESEARCH COUNCIL","MEDICAL RESEARCH COUNCIL"], "activity_status_code":"4", "activity_date_iso_date":["2020-01-01T00:00:00Z","2020-07-01T00:00:00Z","2023-12-31T00:00:00Z","2021-03-31T00:00:00Z"], "activity_date_type":["1","2","3","4"], "contact_info_organisation_narrative":["Department of Business Energy and Industrial Strategy"], "contact_info_department_narrative":["General enquiries"], "contact_info_email":["enquiries@odamanagement.org"], "contact_info_website":["https://www.gov.uk/government/publications/beis-official-development-assistance-research-and-innovation"], "contact_info_mailing_address_narrative":["Department of Business, Energy and Industrial Strategy, 4th Floor, 1 Victoria Street, SW1H 0ET"], "activity_scope_code":"3", "recipient_country_code":["KH","CN","GH","LA","MM","TH","VN"], "recipient_country_percentage":[14.285714285714286,14.285714285714286,14.285714285714286,14.285714285714286,14.285714285714286,14.285714285714286,14.285714285714286], "sector_code":["12182"], "sector_vocabulary":["1"], "policy_marker_code":["1","5","6","7","8","10","11","12"], "policy_marker_significance":["0","0","0","0","0","0","0","0"], "policy_marker_vocabulary":["1","1","1","1","1","1","1","1"], "collaboration_type_code":"1", "default_flow_type_code":"10", "default_finance_type_code":"110", "default_aid_type_code":["D02"], "default_tied_status_code":"5", "budget_status":["1"], "budget_type":["1"], "budget_period_start_iso_date":["2020-04-01T00:00:00Z"], "budget_period_end_iso_date":["2021-03-31T00:00:00Z"], "budget_value":[123952.9], "budget_value_currency":["GBP"], "capital_spend_percentage":0.0, "transaction_type":["3","3","2"], "transaction_date_iso_date":["2021-03-31T00:00:00Z","2020-12-31T00:00:00Z","2020-01-01T00:00:00Z"], "transaction_value":[44557.89,79395.01,697687.56], "transaction_value_currency":["GBP","GBP"], "transaction_value_date":["2021-03-31T00:00:00Z","2020-12-31T00:00:00Z","2020-01-01T00:00:00Z"], "hierarchy":1, "transaction_value_usd":[61743.04524637936,106189.92647889275,912027.187790218] },{ "default_currency":"GBP", "default_lang":"en", "iati_identifier":"GB-GOV-13-FUND--GCRF-MR_T039132_1", "reporting_org_ref":"GB-GOV-13", "reporting_org_type_code":"10", "reporting_org_narrative":["DEPARTMENT FOR BUSINESS, ENERGY & INDUSTRIAL STRATEGY"], "title_narrative":["Sub-Saharan African Network for Congenital Anomalies: Surveillance, Prevention and Care"], "description_narrative":["GCRF Maternal and Neo Health award to set up a Sub-Saharan African Network to promote the prevention of Congenital Anomalies, and care for affected children and families, by building an evidence base through surveillance and research, improving capacity\n","The Global Challenges Research Fund (GCRF) supports cutting-edge research to address challenges faced by developing countries. The fund addresses the UN sustainable development goals. It aims to maximise the impact of research and innovation to improve lives and opportunity in the developing world."], "participating_org_ref":["GB-GOV-13","GB-COH-RC000346","GB-COH-RC000346"], "participating_org_role":["1","2","3","4"], "participating_org_type":["10","15","15","71"], "participating_org_narrative":["DEPARTMENT FOR BUSINESS, ENERGY & INDUSTRIAL STRATEGY","MEDICAL RESEARCH COUNCIL","MEDICAL RESEARCH COUNCIL","MU-JHU CARE LTD"], "activity_status_code":"4", "activity_date_iso_date":["2020-03-01T00:00:00Z","2021-01-01T00:00:00Z","2022-03-31T00:00:00Z","2022-03-31T00:00:00Z"], "activity_date_type":["1","2","3","4"], "contact_info_organisation_narrative":["Department of Business Energy and Industrial Strategy"], "contact_info_department_narrative":["General enquiries"], "contact_info_email":["enquiries@odamanagement.org"], "contact_info_website":["https://www.gov.uk/government/publications/beis-official-development-assistance-research-and-innovation"], "contact_info_mailing_address_narrative":["Department of Business, Energy and Industrial Strategy, 4th Floor, 1 Victoria Street, SW1H 0ET"], "activity_scope_code":"4", "recipient_country_code":["CN"], "recipient_country_percentage":[100.0], "sector_code":["12182"], "sector_vocabulary":["1"], "policy_marker_code":["1","5","6","7","8","10","11","12"], "policy_marker_significance":["0","0","0","0","0","0","2","0"], "policy_marker_vocabulary":["1","1","1","1","1","1","1","1"], "collaboration_type_code":"1", "default_flow_type_code":"10", "default_finance_type_code":"110", "default_aid_type_code":["D02"], "default_tied_status_code":"5", "budget_status":["1","1"], "budget_type":["1","1"], "budget_period_start_iso_date":["2020-04-01T00:00:00Z","2021-04-01T00:00:00Z"], "budget_period_end_iso_date":["2021-03-31T00:00:00Z","2022-03-31T00:00:00Z"], "budget_value":[25202.3,75606.9], "budget_value_currency":["GBP","GBP"], "planned_disbursement_type":["1","2","1"], "planned_disbursement_period_start_iso_date":["2021-10-01T00:00:00Z","2022-04-01T00:00:00Z","2022-07-01T00:00:00Z"], "planned_disbursement_period_end_iso_date":["2021-12-31T00:00:00Z","2022-06-30T00:00:00Z","2022-09-30T00:00:00Z"], "planned_disbursement_value":[2523.99,-6198.25,-6198.25], "planned_disbursement_provider_org_ref":["GB-GOV-13","GB-GOV-13","GB-GOV-13"], "planned_disbursement_provider_org_type":["11","11","10"], "planned_disbursement_provider_org_narrative":["Department for Business, Energy and Industrial Strategy","DEPARTMENT FOR BUSINESS, ENERGY AND INDUSTRIAL STRATEGY","DEPARTMENT FOR BUSINESS, ENERGY & INDUSTRIAL STRATEGY"], "planned_disbursement_provider_org_narrative_text":["Department for Business, Energy and Industrial Strategy","DEPARTMENT FOR BUSINESS, ENERGY AND INDUSTRIAL STRATEGY","DEPARTMENT FOR BUSINESS, ENERGY & INDUSTRIAL STRATEGY"], "planned_disbursement_provider_org_narrative_lang":[" "," "," "], "planned_disbursement_value_date":["2021-10-01T00:00:00Z","2022-04-01T00:00:00Z","2022-07-01T00:00:00Z"], "capital_spend_percentage":0.0, "transaction_type":["3","3","3","2"], "transaction_date_iso_date":["2023-03-31T00:00:00Z","2021-09-30T00:00:00Z","2021-03-31T00:00:00Z","2020-03-01T00:00:00Z"], "transaction_value":[-7099.08,23978.98,12601.15,100809.2], "transaction_value_currency":["GBP","GBP","GBP"], "transaction_value_date":["2023-03-31T00:00:00Z","2021-09-30T00:00:00Z","2021-03-31T00:00:00Z","2020-03-01T00:00:00Z"], "planned_disbursement_value_usd":[3457.6009327448924,-8020.711559357036,-7427.761987858206], "hierarchy":1, "transaction_value_usd":[-8615.66702807624,32911.3358941708,17461.180828051176,124756.39358437277] },{ "default_currency":"GBP", "default_lang":"en", "iati_identifier":"GB-GOV-13-FUND--GCRF-MR_N015967_1", "reporting_org_ref":"GB-GOV-13", "reporting_org_type_code":"10", "reporting_org_narrative":["DEPARTMENT FOR BUSINESS, ENERGY & INDUSTRIAL STRATEGY"], "title_narrative":["Technology-EnaSystem-Integratedbled Model of Care Aiming to Improve the Health of Stroke Patients in Resource-Poor Settings in China"], "description_narrative":["JHSR 2 Full 2015 award to deliver an evidence-based care to patients in their villages and families. To improve their health status by training village doctors and family caregivers, equipping them with innovative digital health technology such as smartph\n","The Global Challenges Research Fund (GCRF) supports cutting-edge research to address challenges faced by developing countries. The fund addresses the UN sustainable development goals. It aims to maximise the impact of research and innovation to improve lives and opportunity in the developing world."], "participating_org_ref":["GB-GOV-13","GB-COH-RC000346","GB-COH-RC000346"], "participating_org_role":["1","2","3","4"], "participating_org_type":["10","15","15","80"], "participating_org_narrative":["DEPARTMENT FOR BUSINESS, ENERGY & INDUSTRIAL STRATEGY","MEDICAL RESEARCH COUNCIL","MEDICAL RESEARCH COUNCIL","QUEEN'S UNIVERSITY BELFAST"], "activity_status_code":"4", "activity_date_iso_date":["2016-01-01T00:00:00Z","2016-04-01T00:00:00Z","2018-12-31T00:00:00Z","2019-03-31T00:00:00Z"], "activity_date_type":["1","2","3","4"], "contact_info_organisation_narrative":["Department of Business Energy and Industrial Strategy"], "contact_info_department_narrative":["General enquiries"], "contact_info_email":["enquiries@odamanagement.org"], "contact_info_website":["https://www.gov.uk/government/publications/beis-official-development-assistance-research-and-innovation"], "contact_info_mailing_address_narrative":["Department of Business, Energy and Industrial Strategy, 4th Floor, 1 Victoria Street, SW1H 0ET"], "activity_scope_code":"4", "recipient_country_code":["CN"], "recipient_country_percentage":[100.0], "sector_code":["12182"], "sector_vocabulary":["1"], "policy_marker_code":["1","5","6","7","8","10","11","12"], "policy_marker_significance":["0","0","0","0","0","0","2","0"], "policy_marker_vocabulary":["1","1","1","1","1","1","1","1"], "collaboration_type_code":"1", "default_flow_type_code":"10", "default_finance_type_code":"110", "default_aid_type_code":["D02"], "default_tied_status_code":"5", "budget_status":["1","1","1"], "budget_type":["1","1","1"], "budget_period_start_iso_date":["2016-04-01T00:00:00Z","2017-04-01T00:00:00Z","2018-04-01T00:00:00Z"], "budget_period_end_iso_date":["2017-03-31T00:00:00Z","2018-03-31T00:00:00Z","2019-03-31T00:00:00Z"], "budget_value":[134593.59,185487.52,139115.36], "budget_value_currency":["GBP","GBP","GBP"], "capital_spend_percentage":0.0, "transaction_type":["3","3","3","3","3","3","3","3","3","3","3","2"], "transaction_date_iso_date":["2020-06-30T00:00:00Z","2018-12-31T00:00:00Z","2018-09-30T00:00:00Z","2018-06-30T00:00:00Z","2018-03-31T00:00:00Z","2017-12-31T00:00:00Z","2017-09-30T00:00:00Z","2017-06-30T00:00:00Z","2017-03-31T00:00:00Z","2016-12-31T00:00:00Z","2016-06-30T00:00:00Z","2016-01-01T00:00:00Z"], "transaction_value":[15547.53,15457.27,15457.27,15457.25,15457.3,15457.3,15457.3,15457.3,15457.3,15457.3,13949.95,505839.08], "transaction_value_currency":["GBP","GBP","GBP","GBP","GBP","GBP","GBP","GBP","GBP","GBP","GBP"], "transaction_value_date":["2020-06-30T00:00:00Z","2018-12-31T00:00:00Z","2018-09-30T00:00:00Z","2018-06-30T00:00:00Z","2018-03-31T00:00:00Z","2017-12-31T00:00:00Z","2017-09-30T00:00:00Z","2017-06-30T00:00:00Z","2017-03-31T00:00:00Z","2016-12-31T00:00:00Z","2016-06-30T00:00:00Z","2016-01-01T00:00:00Z"], "hierarchy":1, "transaction_value_usd":[19468.207796737814,19594.822960236703,20189.72841722543,20544.743022717466,21593.97340016674,20719.34717128614,20601.597470500452,19787.926142396558,19064.12436782828,19315.634747233496,19826.386020699207,728552.3104533036] },{ "default_currency":"GBP", "default_lang":"en", "iati_identifier":"GB-GOV-13-FUND--GCRF-MR_N021037_1", "reporting_org_ref":"GB-GOV-13", "reporting_org_type_code":"10", "reporting_org_narrative":["DEPARTMENT FOR BUSINESS, ENERGY & INDUSTRIAL STRATEGY"], "title_narrative":["Performance of EArly Retinal Laser (PEARL)"], "description_narrative":["MRC/JGHT award looking at whether earlier laser treatment (prior to onset of proliferative retinopathy) improve disease outcomes and compliance with treatment among adults with diabetic retinopathy (DR) in rural and urban China?\n\n","The Global Challenges Research Fund (GCRF) supports cutting-edge research to address challenges faced by developing countries. The fund addresses the UN sustainable development goals. It aims to maximise the impact of research and innovation to improve lives and opportunity in the developing world."], "participating_org_ref":["GB-GOV-13","GB-COH-RC000346","GB-COH-RC000346"], "participating_org_role":["1","2","3","4"], "participating_org_type":["10","15","15","80"], "participating_org_narrative":["DEPARTMENT FOR BUSINESS, ENERGY & INDUSTRIAL STRATEGY","MEDICAL RESEARCH COUNCIL","MEDICAL RESEARCH COUNCIL","QUEEN MARGARET UNIVERSITY EDINBURGH"], "activity_status_code":"4", "activity_date_iso_date":["2016-09-01T00:00:00Z","2016-10-01T00:00:00Z","2018-08-31T00:00:00Z","2019-03-31T00:00:00Z"], "activity_date_type":["1","2","3","4"], "contact_info_organisation_narrative":["Department of Business Energy and Industrial Strategy"], "contact_info_department_narrative":["General enquiries"], "contact_info_email":["enquiries@odamanagement.org"], "contact_info_website":["https://www.gov.uk/government/publications/beis-official-development-assistance-research-and-innovation"], "contact_info_mailing_address_narrative":["Department of Business, Energy and Industrial Strategy, 4th Floor, 1 Victoria Street, SW1H 0ET"], "activity_scope_code":"4", "recipient_country_code":["CN"], "recipient_country_percentage":[100.0], "sector_code":["12182"], "sector_vocabulary":["1"], "policy_marker_code":["1","5","6","7","8","10","11","12"], "policy_marker_significance":["0","0","0","0","0","0","0","0"], "policy_marker_vocabulary":["1","1","1","1","1","1","1","1"], "collaboration_type_code":"1", "default_flow_type_code":"10", "default_finance_type_code":"110", "default_aid_type_code":["D02"], "default_tied_status_code":"5", "budget_status":["1","1","1"], "budget_type":["1","1","1"], "budget_period_start_iso_date":["2016-04-01T00:00:00Z","2017-04-01T00:00:00Z","2018-04-01T00:00:00Z"], "budget_period_end_iso_date":["2017-03-31T00:00:00Z","2018-03-31T00:00:00Z","2019-03-31T00:00:00Z"], "budget_value":[36432.52,73160.12,18363.8], "budget_value_currency":["GBP","GBP","GBP"], "capital_spend_percentage":0.0, "transaction_type":["3","3","3","3","3","3","3","2"], "transaction_date_iso_date":["2019-06-30T00:00:00Z","2018-06-30T00:00:00Z","2018-03-31T00:00:00Z","2017-12-31T00:00:00Z","2017-09-30T00:00:00Z","2017-06-30T00:00:00Z","2017-03-31T00:00:00Z","2016-09-01T00:00:00Z"], "transaction_value":[3584.2,3672.76,3672.76,3672.76,3643.25,3643.25,7286.5,146320.2], "transaction_value_currency":["GBP","GBP","GBP","GBP","GBP","GBP","GBP"], "transaction_value_date":["2019-06-30T00:00:00Z","2018-06-30T00:00:00Z","2018-03-31T00:00:00Z","2017-12-31T00:00:00Z","2017-09-30T00:00:00Z","2017-06-30T00:00:00Z","2017-03-31T00:00:00Z","2016-09-01T00:00:00Z"], "hierarchy":1, "transaction_value_usd":[4543.627305859987,4881.586982426745,5130.875492174985,4923.0583295150445,4855.74906254008,4663.968605014217,8986.740388436581,192270.2827894136] },{ "default_currency":"GBP", "default_lang":"en", "iati_identifier":"GB-GOV-13-FUND--GCRF-MR_P021336_1", "reporting_org_ref":"GB-GOV-13", "reporting_org_type_code":"10", "reporting_org_narrative":["DEPARTMENT FOR BUSINESS, ENERGY & INDUSTRIAL STRATEGY"], "title_narrative":["The use of human monoclonal antibodies to inform and enhance influenza vaccine virus selection."], "description_narrative":["IIB Research Boards Sep/Oct 2016 RM 2017 award to look at the use of human monoclonal antibodies to inform and enhance influenza vaccine virus selection in China\n","The Global Challenges Research Fund (GCRF) supports cutting-edge research to address challenges faced by developing countries. The fund addresses the UN sustainable development goals. It aims to maximise the impact of research and innovation to improve lives and opportunity in the developing world."], "participating_org_ref":["GB-GOV-13","GB-COH-RC000346","GB-COH-RC000346","GB-UKPRN-10007774"], "participating_org_role":["1","2","3","4"], "participating_org_type":["10","15","15","80"], "participating_org_narrative":["DEPARTMENT FOR BUSINESS, ENERGY & INDUSTRIAL STRATEGY","MEDICAL RESEARCH COUNCIL","MEDICAL RESEARCH COUNCIL","UNIVERSITY OF OXFORD"], "activity_status_code":"4", "activity_date_iso_date":["2017-04-03T00:00:00Z","2017-08-18T00:00:00Z","2020-04-02T00:00:00Z","2021-05-10T00:00:00Z"], "activity_date_type":["1","2","3","4"], "contact_info_organisation_narrative":["Department of Business Energy and Industrial Strategy"], "contact_info_department_narrative":["General enquiries"], "contact_info_email":["enquiries@odamanagement.org"], "contact_info_website":["https://www.gov.uk/government/publications/beis-official-development-assistance-research-and-innovation"], "contact_info_mailing_address_narrative":["Department of Business, Energy and Industrial Strategy, 4th Floor, 1 Victoria Street, SW1H 0ET"], "activity_scope_code":"4", "recipient_country_code":["CN"], "recipient_country_percentage":[100.0], "sector_code":["12182"], "sector_vocabulary":["1"], "policy_marker_code":["1","5","6","7","8","10","11","12"], "policy_marker_significance":["0","0","0","0","0","0","0","0"], "policy_marker_vocabulary":["1","1","1","1","1","1","1","1"], "collaboration_type_code":"1", "default_flow_type_code":"10", "default_finance_type_code":"110", "default_aid_type_code":["D02"], "default_tied_status_code":"5", "budget_status":["1","1","1","1"], "budget_type":["1","1","1","1"], "budget_period_start_iso_date":["2017-04-01T00:00:00Z","2018-04-01T00:00:00Z","2019-04-01T00:00:00Z","2020-04-01T00:00:00Z"], "budget_period_end_iso_date":["2018-03-31T00:00:00Z","2019-03-31T00:00:00Z","2020-03-31T00:00:00Z","2021-03-31T00:00:00Z"], "budget_value":[165832.58,333008.44,335705.86,84265.0], "budget_value_currency":["GBP","GBP","GBP","GBP"], "capital_spend_percentage":0.0, "transaction_type":["3","3","3","3","3","3","3","3","3","3","3","3","2"], "transaction_date_iso_date":["2021-09-30T00:00:00Z","2020-06-30T00:00:00Z","2020-03-31T00:00:00Z","2019-12-31T00:00:00Z","2019-09-30T00:00:00Z","2019-06-30T00:00:00Z","2019-03-31T00:00:00Z","2018-12-31T00:00:00Z","2018-09-30T00:00:00Z","2018-06-30T00:00:00Z","2018-03-31T00:00:00Z","2017-12-31T00:00:00Z","2017-04-03T00:00:00Z"], "transaction_value":[19201.48,84265.0,84265.0,84265.0,83587.93,83587.93,83587.93,83587.93,82916.29,82916.29,82916.29,82916.29,1003076.97], "transaction_value_currency":["GBP","GBP","GBP","GBP","GBP","GBP","GBP","GBP","GBP","GBP","GBP","GBP"], "transaction_value_date":["2021-09-30T00:00:00Z","2020-06-30T00:00:00Z","2020-03-31T00:00:00Z","2019-12-31T00:00:00Z","2019-09-30T00:00:00Z","2019-06-30T00:00:00Z","2019-03-31T00:00:00Z","2018-12-31T00:00:00Z","2018-09-30T00:00:00Z","2018-06-30T00:00:00Z","2018-03-31T00:00:00Z","2017-12-31T00:00:00Z","2017-04-03T00:00:00Z"], "hierarchy":1, "transaction_value_usd":[26354.180117136042,105514.41482937237,104282.12410560912,110639.6717414851,103322.90621342059,105962.94882771978,110085.72612525268,105962.48172948121,108302.26660101718,110206.78778224574,115834.72926711076,111143.04559431733,1267868.9989787352] },{ "default_currency":"GBP", "default_lang":"en", "iati_identifier":"GB-GOV-13-FUND--GCRF-MR_S014551_1", "reporting_org_ref":"GB-GOV-13", "reporting_org_type_code":"10", "reporting_org_narrative":["DEPARTMENT FOR BUSINESS, ENERGY & INDUSTRIAL STRATEGY"], "title_narrative":["Developing a multiplex serology panel to detect and quantify Epstein-Barr virus infection"], "description_narrative":["MRC/Global Cancer Research Grant to study will develop and validate a panel capable of measuring and quantifying the amounts of EpsteinBarr virus biomarkers. The panel will be part of a pilot casecohort study including 200 each of Nasopharyngeal Cancer, g\n","The Global Challenges Research Fund (GCRF) supports cutting-edge research to address challenges faced by developing countries. The fund addresses the UN sustainable development goals. It aims to maximise the impact of research and innovation to improve lives and opportunity in the developing world."], "participating_org_ref":["GB-GOV-13","GB-COH-RC000346","GB-COH-RC000346","GB-UKPRN-10007774"], "participating_org_role":["1","2","3","4"], "participating_org_type":["10","15","15","80"], "participating_org_narrative":["DEPARTMENT FOR BUSINESS, ENERGY & INDUSTRIAL STRATEGY","MEDICAL RESEARCH COUNCIL","MEDICAL RESEARCH COUNCIL","UNIVERSITY OF OXFORD"], "activity_status_code":"4", "activity_date_iso_date":["2018-11-01T00:00:00Z","2018-11-01T00:00:00Z","2021-10-31T00:00:00Z","2021-10-31T00:00:00Z"], "activity_date_type":["1","2","3","4"], "contact_info_organisation_narrative":["Department of Business Energy and Industrial Strategy"], "contact_info_department_narrative":["General enquiries"], "contact_info_email":["enquiries@odamanagement.org"], "contact_info_website":["https://www.gov.uk/government/publications/beis-official-development-assistance-research-and-innovation"], "contact_info_mailing_address_narrative":["Department of Business, Energy and Industrial Strategy, 4th Floor, 1 Victoria Street, SW1H 0ET"], "activity_scope_code":"4", "recipient_country_code":["CN"], "recipient_country_percentage":[100.0], "sector_code":["12182"], "sector_vocabulary":["1"], "policy_marker_code":["1","5","6","7","8","10","11","12"], "policy_marker_significance":["0","0","0","0","0","0","0","0"], "policy_marker_vocabulary":["1","1","1","1","1","1","1","1"], "collaboration_type_code":"1", "default_flow_type_code":"10", "default_finance_type_code":"110", "default_aid_type_code":["D02"], "default_tied_status_code":"5", "budget_status":["1","1"], "budget_type":["1","1"], "budget_period_start_iso_date":["2018-04-01T00:00:00Z","2019-04-01T00:00:00Z"], "budget_period_end_iso_date":["2019-03-31T00:00:00Z","2020-03-31T00:00:00Z"], "budget_value":[49061.92,102109.35], "budget_value_currency":["GBP","GBP"], "planned_disbursement_type":["1","1","1"], "planned_disbursement_period_start_iso_date":["2022-04-01T00:00:00Z","2022-07-01T00:00:00Z","2022-10-01T00:00:00Z"], "planned_disbursement_period_end_iso_date":["2022-06-30T00:00:00Z","2022-09-30T00:00:00Z","2022-12-31T00:00:00Z"], "planned_disbursement_value":[34219.79,34219.79,34219.79], "planned_disbursement_provider_org_ref":["GB-GOV-13","GB-GOV-13","GB-GOV-13"], "planned_disbursement_provider_org_type":["11","10","10"], "planned_disbursement_provider_org_narrative":["DEPARTMENT FOR BUSINESS, ENERGY AND INDUSTRIAL STRATEGY","DEPARTMENT FOR BUSINESS, ENERGY & INDUSTRIAL STRATEGY","DEPARTMENT FOR BUSINESS, ENERGY & INDUSTRIAL STRATEGY"], "planned_disbursement_provider_org_narrative_text":["DEPARTMENT FOR BUSINESS, ENERGY AND INDUSTRIAL STRATEGY","DEPARTMENT FOR BUSINESS, ENERGY & INDUSTRIAL STRATEGY","DEPARTMENT FOR BUSINESS, ENERGY & INDUSTRIAL STRATEGY"], "planned_disbursement_provider_org_narrative_lang":[" "," "," "], "planned_disbursement_value_date":["2022-04-01T00:00:00Z","2022-07-01T00:00:00Z","2022-10-01T00:00:00Z"], "capital_spend_percentage":0.0, "transaction_type":["3","3","3","3","3","3","2"], "transaction_date_iso_date":["2022-12-31T00:00:00Z","2019-12-31T00:00:00Z","2019-09-30T00:00:00Z","2019-06-30T00:00:00Z","2019-03-31T00:00:00Z","2018-12-31T00:00:00Z","2018-11-01T00:00:00Z"], "transaction_value":[26892.93,34219.75,33944.8,33944.8,24530.96,24530.96,185391.06], "transaction_value_currency":["GBP","GBP","GBP","GBP","GBP","GBP"], "transaction_value_date":["2022-12-31T00:00:00Z","2019-12-31T00:00:00Z","2019-09-30T00:00:00Z","2019-06-30T00:00:00Z","2019-03-31T00:00:00Z","2018-12-31T00:00:00Z","2018-11-01T00:00:00Z"], "planned_disbursement_value_usd":[44281.38026245639,41007.77725882151,38649.180234043895], "hierarchy":1, "transaction_value_usd":[32828.951594778664,44930.42078058132,41959.112838819194,43031.225984028824,32307.398258929596,31097.329492507288,239187.83151477503] },{ "default_currency":"GBP", "default_lang":"en", "iati_identifier":"GB-GOV-13-FUND--GCRF-MR_T008547_1", "reporting_org_ref":"GB-GOV-13", "reporting_org_type_code":"10", "reporting_org_narrative":["DEPARTMENT FOR BUSINESS, ENERGY & INDUSTRIAL STRATEGY"], "title_narrative":["Diet, biomarkers and non-communicable diseases in rural and urban China: federated analysis of population-based studies"], "description_narrative":["MRC mechanistic Nutrition award lookng at the diet, biomarkers and noncommunicable diseases in rural and urban China: federated analysis of populationbased studiesDiet (i.e. intake of specific foods, nutrients, and overall dietary patterns) plays an important role in the development and progression of NCDs, which is the leading cause of early death and disability. However, the majority of the previous studies were conducted in high-income Western countries, with limited information available from low- and middle-income countries (LMICs), such as China, where nearly three-quarters of NCDs occur. This lack of robust information makes it difficult to formulate evidence-based dietary guidelines for NCD prevention in these countries. More importantly, associations observed only in a specific population (or few similar populations) may not be the true effect of diet, but due to the impact of other factors which are closely related to dietary habits, e.g. socio-demographic factors or other lifestyle factors (e.g. physical activity). Therefore, studying the association between diet and NCDs in LMICs has become very important because populations in these countries, compared to those living in Western countries, have very distinct dietary and disease patterns and the correlations between dietary factors and socio-demographic factors are also very different. Moreover, the exact biological mechanisms through which diet exert its effect on NCD incidence and progression is largely unknown. A better understanding of such mechanisms will greatly enhance our capacity to effectively prevent and treat these diseases. In this proposal, we plan to bring together several large population based studies which in total involves > 1 million Chinese adults for whom information on dietary habits, biomarkers which are closely related to metabolism status of the body, and incidence of NCDs is available, together with long-term stored bio-samples. Joint analyses of existing as well as newly generated omics (i.e. MS-Metabolomics and Metagenomics) data will be performed in order to have a comprehensive robust assessment of diet and NCD association as well as potential underlying mechanisms.","The Global Challenges Research Fund (GCRF) supports cutting-edge research to address challenges faced by developing countries. The fund addresses the UN sustainable development goals. It aims to maximise the impact of research and innovation to improve lives and opportunity in the developing world."], "participating_org_ref":["GB-GOV-13","GB-COH-RC000346","GB-COH-RC000346"], "participating_org_role":["1","2","3"], "participating_org_type":["10","15","15"], "participating_org_narrative":["DEPARTMENT FOR BUSINESS, ENERGY & INDUSTRIAL STRATEGY","MEDICAL RESEARCH COUNCIL","MEDICAL RESEARCH COUNCIL"], "activity_status_code":"4", "activity_date_iso_date":["2019-08-01T00:00:00Z","2019-08-01T00:00:00Z","2020-05-31T00:00:00Z","2020-05-31T00:00:00Z"], "activity_date_type":["1","2","3","4"], "contact_info_organisation_narrative":["Department of Business Energy and Industrial Strategy"], "contact_info_department_narrative":["General enquiries"], "contact_info_email":["enquiries@odamanagement.org"], "contact_info_website":["https://www.gov.uk/government/publications/beis-official-development-assistance-research-and-innovation"], "contact_info_mailing_address_narrative":["Department of Business, Energy and Industrial Strategy, 4th Floor, 1 Victoria Street, SW1H 0ET"], "activity_scope_code":"4", "recipient_country_code":["CN"], "recipient_country_percentage":[100.0], "sector_code":["12182"], "sector_vocabulary":["1"], "policy_marker_code":["1","5","6","7","8","10","11","12"], "policy_marker_significance":["0","0","0","0","0","0","0","2"], "policy_marker_vocabulary":["1","1","1","1","1","1","1","1"], "collaboration_type_code":"1", "default_flow_type_code":"10", "default_finance_type_code":"110", "default_aid_type_code":["D02"], "default_tied_status_code":"5", "budget_status":["1"], "budget_type":["1"], "budget_period_start_iso_date":["2019-04-01T00:00:00Z"], "budget_period_end_iso_date":["2020-03-31T00:00:00Z"], "budget_value":[22436.78], "budget_value_currency":["GBP"], "capital_spend_percentage":0.0, "transaction_type":["3","3","2"], "transaction_date_iso_date":["2020-12-31T00:00:00Z","2019-12-31T00:00:00Z","2019-08-01T00:00:00Z"], "transaction_value":[-12938.36,22436.78,32052.55], "transaction_value_currency":["GBP","GBP"], "transaction_value_date":["2020-12-31T00:00:00Z","2019-12-31T00:00:00Z","2019-08-01T00:00:00Z"], "hierarchy":1, "transaction_value_usd":[-17304.909932720548,29459.419380951975,38931.57643422243] },{ "default_currency":"GBP", "default_lang":"en", "iati_identifier":"GB-GOV-13-FUND--GCRF-MR_T003995_1", "reporting_org_ref":"GB-GOV-13", "reporting_org_type_code":"10", "reporting_org_narrative":["DEPARTMENT FOR BUSINESS, ENERGY & INDUSTRIAL STRATEGY"], "title_narrative":["Syphilis self-testing to expand test uptake among men who have sex with men (SST)"], "description_narrative":["MRC JGHT award to develop Syphilis selftesting to expand test uptake among men who have sex with men (SST)\n","The Global Challenges Research Fund (GCRF) supports cutting-edge research to address challenges faced by developing countries. The fund addresses the UN sustainable development goals. It aims to maximise the impact of research and innovation to improve lives and opportunity in the developing world."], "participating_org_ref":["GB-GOV-13","GB-COH-RC000346","GB-COH-RC000346"], "participating_org_role":["1","2","3","4"], "participating_org_type":["10","15","15","80"], "participating_org_narrative":["DEPARTMENT FOR BUSINESS, ENERGY & INDUSTRIAL STRATEGY","MEDICAL RESEARCH COUNCIL","MEDICAL RESEARCH COUNCIL","LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE"], "activity_status_code":"4", "activity_date_iso_date":["2019-09-01T00:00:00Z","2019-09-01T00:00:00Z","2021-02-28T00:00:00Z","2021-02-28T00:00:00Z"], "activity_date_type":["1","2","3","4"], "contact_info_organisation_narrative":["Department of Business Energy and Industrial Strategy"], "contact_info_department_narrative":["General enquiries"], "contact_info_email":["enquiries@odamanagement.org"], "contact_info_website":["https://www.gov.uk/government/publications/beis-official-development-assistance-research-and-innovation"], "contact_info_mailing_address_narrative":["Department of Business, Energy and Industrial Strategy, 4th Floor, 1 Victoria Street, SW1H 0ET"], "activity_scope_code":"4", "recipient_country_code":["CN"], "recipient_country_percentage":[100.0], "sector_code":["12182"], "sector_vocabulary":["1"], "policy_marker_code":["1","5","6","7","8","10","11","12"], "policy_marker_significance":["0","0","0","0","0","0","0","0"], "policy_marker_vocabulary":["1","1","1","1","1","1","1","1"], "collaboration_type_code":"1", "default_flow_type_code":"10", "default_finance_type_code":"110", "default_aid_type_code":["D02"], "default_tied_status_code":"5", "budget_status":["1","1"], "budget_type":["1","1"], "budget_period_start_iso_date":["2019-04-01T00:00:00Z","2020-04-01T00:00:00Z"], "budget_period_end_iso_date":["2020-03-31T00:00:00Z","2021-03-31T00:00:00Z"], "budget_value":[49480.98,99362.85], "budget_value_currency":["GBP","GBP"], "planned_disbursement_type":["1"], "planned_disbursement_period_start_iso_date":["2022-01-01T00:00:00Z"], "planned_disbursement_period_end_iso_date":["2022-03-31T00:00:00Z"], "planned_disbursement_value":[6235.24], "planned_disbursement_provider_org_ref":["GB-GOV-13"], "planned_disbursement_provider_org_type":["11"], "planned_disbursement_provider_org_narrative":["Department for Business, Energy and Industrial Strategy"], "planned_disbursement_provider_org_narrative_text":["Department for Business, Energy and Industrial Strategy"], "planned_disbursement_provider_org_narrative_lang":[" "], "planned_disbursement_value_date":["2022-01-01T00:00:00Z"], "capital_spend_percentage":0.0, "transaction_type":["3","3","3","3","3","3","2"], "transaction_date_iso_date":["2022-03-31T00:00:00Z","2020-12-31T00:00:00Z","2020-09-30T00:00:00Z","2020-06-30T00:00:00Z","2020-03-31T00:00:00Z","2019-12-31T00:00:00Z","2019-09-01T00:00:00Z"], "transaction_value":[6070.24,6235.23,5850.26,5875.61,6185.12,6185.12,148843.83], "transaction_value_currency":["GBP","GBP","GBP","GBP","GBP","GBP"], "transaction_value_date":["2022-03-31T00:00:00Z","2020-12-31T00:00:00Z","2020-09-30T00:00:00Z","2020-06-30T00:00:00Z","2020-03-31T00:00:00Z","2019-12-31T00:00:00Z","2019-09-01T00:00:00Z"], "planned_disbursement_value_usd":[8447.145412649123], "hierarchy":1, "transaction_value_usd":[7997.907791994977,8339.54949157367,7579.327779731071,7357.284173922845,7654.393300279892,8121.04250260125,183985.61954502665] },{ "default_currency":"GBP", "default_lang":"en", "iati_identifier":"GB-GOV-13-FUND--GCRF-MR_T024399_1", "reporting_org_ref":"GB-GOV-13", "reporting_org_type_code":"10", "reporting_org_narrative":["DEPARTMENT FOR BUSINESS, ENERGY & INDUSTRIAL STRATEGY"], "title_narrative":["School-based education programme to reduce salt: Scaling-up in China (EduSaltS)"], "description_narrative":["High salt intake increases the risk of high blood pressure, strokes, heart disease, and several other chronic diseases such as stomach cancer. Salt intake in China is very high with an average of 12-14 gram per day, more than double the WHO recommended level of 5 gram per day. Unlike the UK and other developed countries, 75%-80% of the salt in the Chinese diet is added by the consumers during cooking or in sauces. An effective strategy to reduce salt from home cooking is of great urgency and importance, not only for China, but also for many other developing countries. However, it is very difficult for individuals to change their eating habits. Our proposed research will build upon a successfully-tested pilot study entitled \"School-based education programme to reduce Salt\" (School-EduSalt) in China, in which primary school children were educated, during their usual health education lessons, about the effects of salt on health and how to reduce salt intake. Children then instructed their family members to reduce the amount of salt used during food preparations at home. The results of this pilot study have shown that the school-based education is very effective in reducing salt intake in children and adults. The pilot study was carried out in one city called Changzhi, in northern China. We now propose to do a study to test whether we can scale up a refined School-EduSalt programme in multiple settings, to reduce salt in larger populations in China, including the poorest population living in the remote and rural areas. This scale-up study will be carried out in three regions of China including Beijing (capital of China), Shijiazhuang (in the north) and Zhenjiang (in the south), covering a population of over 1 million school children and 2.2 million adults. The study will involve a number of important stakeholders, including governmental organisations, and the health and education authorities of the three regions. Based on WHO's Conceptual Framework for Scaling up, we will work with these stakeholders to develop, implement and evaluate a feasible scale-up package, which will be integrated into the existing school health education system to ensure sustainable scaling-up. The scale-up package will be evaluated in three aspects: effectiveness, process and health economics. We will assess whether the education programme can improve the participants' knowledge, attitudes and practices towards salt reduction. Additionally, we will assess whether the education programme can achieve a sustainable reduction in salt intake which will be measured by the gold standard method of 24-hour urine collection. Our ultimate aim is to incorporate the refined education programme into the national school curriculum, so that all schools in China will follow. A nation-wide implementation will have an enormous impact on reducing population salt intake. A reduction in salt intake across the whole population, even by a small amount, will lower population blood pressure and prevent hundreds of thousands of strokes, heart attacks and heart failure each year, and also lead to major cost-savings to individuals, their families and the health service.","The Global Challenges Research Fund (GCRF) supports cutting-edge research to address challenges faced by developing countries. The fund addresses the UN sustainable development goals. It aims to maximise the impact of research and innovation to improve lives and opportunity in the developing world."], "participating_org_ref":["GB-GOV-13","GB-COH-RC000346","GB-COH-RC000346"], "participating_org_role":["1","2","3"], "participating_org_type":["10","15","15"], "participating_org_narrative":["DEPARTMENT FOR BUSINESS, ENERGY & INDUSTRIAL STRATEGY","MEDICAL RESEARCH COUNCIL","MEDICAL RESEARCH COUNCIL"], "activity_status_code":"4", "activity_date_iso_date":["2019-09-16T00:00:00Z","2019-12-02T00:00:00Z","2023-09-15T00:00:00Z","2021-03-31T00:00:00Z"], "activity_date_type":["1","2","3","4"], "contact_info_organisation_narrative":["Department of Business Energy and Industrial Strategy"], "contact_info_department_narrative":["General enquiries"], "contact_info_email":["enquiries@odamanagement.org"], "contact_info_website":["https://www.gov.uk/government/publications/beis-official-development-assistance-research-and-innovation"], "contact_info_mailing_address_narrative":["Department of Business, Energy and Industrial Strategy, 4th Floor, 1 Victoria Street, SW1H 0ET"], "activity_scope_code":"4", "recipient_country_code":["CN"], "recipient_country_percentage":[100.0], "sector_code":["12182"], "sector_vocabulary":["1"], "policy_marker_code":["1","5","6","7","8","10","11","12"], "policy_marker_significance":["0","0","0","0","0","0","0","2"], "policy_marker_vocabulary":["1","1","1","1","1","1","1","1"], "collaboration_type_code":"1", "default_flow_type_code":"10", "default_finance_type_code":"110", "default_aid_type_code":["D02"], "default_tied_status_code":"5", "budget_status":["1","1"], "budget_type":["1","1"], "budget_period_start_iso_date":["2019-04-01T00:00:00Z","2020-04-01T00:00:00Z"], "budget_period_end_iso_date":["2020-03-31T00:00:00Z","2021-03-31T00:00:00Z"], "budget_value":[77576.94,310936.13], "budget_value_currency":["GBP","GBP"], "capital_spend_percentage":0.0, "transaction_type":["3","3","3","3","3","2"], "transaction_date_iso_date":["2021-03-31T00:00:00Z","2020-12-31T00:00:00Z","2020-09-30T00:00:00Z","2020-06-30T00:00:00Z","2020-03-31T00:00:00Z","2019-09-16T00:00:00Z"], "transaction_value":[78205.31,77576.94,77576.94,77576.94,77576.94,2512787.08], "transaction_value_currency":["GBP","GBP","GBP","GBP","GBP"], "transaction_value_date":["2021-03-31T00:00:00Z","2020-12-31T00:00:00Z","2020-09-30T00:00:00Z","2020-06-30T00:00:00Z","2020-03-31T00:00:00Z","2019-09-16T00:00:00Z"], "hierarchy":1, "transaction_value_usd":[108367.65371603376,103758.27844920577,100505.11539803879,97139.80215217861,96005.31756735766,3106052.0795422858] },{ "default_currency":"GBP", "default_lang":"en", "iati_identifier":"GB-GOV-13-FUND--GCRF-MR_T00858X_1", "reporting_org_ref":"GB-GOV-13", "reporting_org_type_code":"10", "reporting_org_narrative":["DEPARTMENT FOR BUSINESS, ENERGY & INDUSTRIAL STRATEGY"], "title_narrative":["Mechanisms of intergenerational nutritional programming of non-communicable diseases in three countries: a Healthy Life Trajectories Initiative study."], "description_narrative":["Non-communicable diseases (NCDs) such as heart disease and diabetes are rapidly increasing in low- and middle-income countries (LMICs). These diseases are occurring at younger ages in LMICs compared to high-income countries, with accompanying economic and societal costs. There are now ~166 million people with diabetes in India and China alone (40% of the world's total). Current approaches to preventing diabetes or heart disease focus on weight reduction and increased physical activity in middle-aged adults with existing risk factors such as obesity or high blood pressure. While such approaches offer some benefit to the individual, they do little to address the risk in future generations. Research from many countries across the world has shown that low birth weight and poor growth of the fetus in the womb is related to an increased risk of developing diabetes and heart disease in later life. These effects are exacerbated by greater weight gain during childhood, adolescence or adulthood. It is suggested that undernutrition during critical periods of early development permanently alters the structure and function of the body's tissues and organs ('programming'), leading to an increased vulnerability to disease in later life. It is therefore possible that measures to optimise the health of young women before and during pregnancy, and measures to optimise the growth of infants and young children may have long-term beneficial effects on the health of the children. In this context, the Healthy Life Trajectories Initiative (HeLTI) programme was set up as a joint initiative funded by the Canadian Institutes of Health Research, Department of Biotechnology (India), Medical Research Council (South Africa) and the National Natural Science Foundation (China), in collaboration with the World Health Organisation. There are four separate but harmonised intervention studies in Mysore (India), Johannesburg (South Africa), Shanghai (China) and two provinces in Canada. The studies will test the concept that interventions addressing multiple domains of health spanning from before pregnancy, and continued through pregnancy and after birth will improve maternal and child health including the long-term well-being of the child. Our main outcome is a measure of adiposity (fat mass in relation to height) at five years of age in the child. While the exact intervention packages vary by country to ensure cultural and contextual appropriateness, they are all unified by both the overall aim of the intervention and approach. The studies are at slightly different points - two of the studies are in the preparatory phase while the other two have started the main study. As part of the main study, we will be collecting a range of biospecimens (blood, buccal and vaginal swabs, urine, stool, cord blood and placenta) from the women/mothers, fathers and children. Under this grant, we would like to undertake analyses of a selection of these biological samples, in order to understand how early life factors impact long-term health. In this outline call, we will standardise our procedures for processing biological samples, and finalise our plans for analyses. The results will help us in understanding the mechanisms by which poor fetal growth and undernutrition leads to NCDs in later life. The findings will have important global policy implications as the studies comprise Asian, African and Caucasian populations.","The Global Challenges Research Fund (GCRF) supports cutting-edge research to address challenges faced by developing countries. The fund addresses the UN sustainable development goals. It aims to maximise the impact of research and innovation to improve lives and opportunity in the developing world."], "participating_org_ref":["GB-GOV-13","GB-COH-RC000346","GB-COH-RC000346"], "participating_org_role":["1","2","3"], "participating_org_type":["10","15","15"], "participating_org_narrative":["DEPARTMENT FOR BUSINESS, ENERGY & INDUSTRIAL STRATEGY","MEDICAL RESEARCH COUNCIL","MEDICAL RESEARCH COUNCIL"], "activity_status_code":"4", "activity_date_iso_date":["2019-07-01T00:00:00Z","2019-10-03T00:00:00Z","2020-04-30T00:00:00Z","2020-08-02T00:00:00Z"], "activity_date_type":["1","2","3","4"], "contact_info_organisation_narrative":["Department of Business Energy and Industrial Strategy"], "contact_info_department_narrative":["General enquiries"], "contact_info_email":["enquiries@odamanagement.org"], "contact_info_website":["https://www.gov.uk/government/publications/beis-official-development-assistance-research-and-innovation"], "contact_info_mailing_address_narrative":["Department of Business, Energy and Industrial Strategy, 4th Floor, 1 Victoria Street, SW1H 0ET"], "activity_scope_code":"3", "recipient_country_code":["CN","IN","ZA"], "recipient_country_percentage":[33.333333333333336,33.333333333333336,33.333333333333336], "sector_code":["12182"], "sector_vocabulary":["1"], "policy_marker_code":["1","5","6","7","8","10","11","12"], "policy_marker_significance":["0","0","0","0","0","0","0","2"], "policy_marker_vocabulary":["1","1","1","1","1","1","1","1"], "collaboration_type_code":"1", "default_flow_type_code":"10", "default_finance_type_code":"110", "default_aid_type_code":["D02"], "default_tied_status_code":"5", "budget_status":["1"], "budget_type":["1"], "budget_period_start_iso_date":["2019-04-01T00:00:00Z"], "budget_period_end_iso_date":["2020-03-31T00:00:00Z"], "budget_value":[24361.08], "budget_value_currency":["GBP"], "capital_spend_percentage":0.0, "transaction_type":["3","3","3","2"], "transaction_date_iso_date":["2020-12-31T00:00:00Z","2020-03-31T00:00:00Z","2019-12-31T00:00:00Z","2019-07-01T00:00:00Z"], "transaction_value":[4898.8,12180.54,12180.54,34801.53], "transaction_value_currency":["GBP","GBP","GBP"], "transaction_value_date":["2020-12-31T00:00:00Z","2020-03-31T00:00:00Z","2019-12-31T00:00:00Z","2019-07-01T00:00:00Z"], "hierarchy":1, "transaction_value_usd":[6552.089505811511,15074.02342554247,15993.009520370604,43397.09150940198] }] } }