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      "description_narrative":["With an estimated 214 million people l--mostly from poor agricultural regions to more industrialized countries-international migration is a key concern in scholarly and policy arenas. This unprecedented phenomenon has wide-ranging consequences both for migrant-sending and receiving locations. This study focuses on one specific, but crucial consequence - the impact of labor outmigration on agricultural productivity in migrant-sending areas. As the agriculture productivity in poor subsistence economies is closely connected with one of the world's epidemic problems: food security. FAO estimated about 870 million people were undernourished in the period 2010-12. The vast majority of these - 852 million live in developing countries. Thus, increased agricultural productivity in poor countries is a key tool for alleviating this problem. This proposed project aims to better understand the relationship between labor outmigration and agriculture, providing crucial information for scientific and policy development of food security concerns.\nUnderstanding the link between outmigration and agriculture is complicated by the fact that migration does not happen randomly. Additionally, changes in agricultural practices and migration are likely to influence each other. Thus, the empirical demands for adjudicating potential reciprocal relationships are high, limiting the ability of previous research to speak to these questions. To address this complication, we will leverage the Chitwan Valley Family Study (CVFS), a case control comparison design at the community level with a 15-year panel study of a stratified systematic sample of communities, households, and individuals in Nepal.","Research and development activity contributing to the UK’s strategy to address key development challenges."],
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      "description_narrative":["This project aims at developing a comprehensive scheme for enhancing the seismic safety and resilience of school buildings in Nepal. The circle of resilience initiates from a holistic seismic hazard assessment considering refined geological mapping, 3D site and topographic effects as well as seismicity sequence using statistical clustering models. This will be followed by the development of a smart diagnostics expert system app for reliable pre- and post-earthquake structural inspection. Its core logic will be based on US FEMA and ATC-20i standards extended to address functionality risks, inspection bias reduction based on inspection error patterns identified in the existing school buildings databases in Greece and Turkey. The above state-of-the-art hazard and vulnerability assessments will lead to the risk-based prioritization of schools that need strengthening. Particular emphasis in the diagnostics algorithm will be placed in identifying buildings with minor-to moderate damage, whose safety could be substantially improved with innovative yet simple measures.     Along these lines, means of repair and retrofit will be identified by experimental testing of large and/or full scale, one storey-one classroom, 3D masonry and/or adobe/rammed earth simple buildings, as well as of one bay R/C infill frame, to be conducted at the shaking table of the University of Bristol and the University of Southampton in collaboration with the University of Bullafo, SUNY. Experiments will be co-designed with the project local partners in Nepal, where preliminary material testing will take place. The aim is to design a realistic testing campaign tailored to the construction characteristics of school buildings in Nepal. A deep understanding of the structural damage patterns will be obtained in the Laboratory by studying experimentally and verifying numerically, the cumulative damage under realistic mainshock and aftershock sequences, an issue that has never been studied at this extent. Innovative repair and retrofit techniques will be tested in order to assess and optimize their efficiency through an additional experimental set. Refined and simple solutions will be tested, co-produced and documented in the form of guidelines along with the local partners. An innovative concept of seismic isolation using natural materials will be the second major strand of experimental research for safer \"sliding\" construction of school buildings and shelters. This is aimed to provide a new alternative for low cost - high safety reconstruction.  A comprehensive post-quake vulnerability assessment will then be developed accounting for regional materials and employing micro- and meso-fragility modelling for informed decision-making during the post-earthquake response, recovery and mitigation phases. This will build upon the existing emergency plans in Nepal with the specific aim to enrich the decision-making process by integrating post-quake shake maps in nearly real time. A tablet app will also be developed for reliable diagnostics of post-quake structural health based on the spectral-based FAST algorithm, a tested method in seismically active Mediterranean countries. An expert system will further link the identified damage states with the most appropriate repair/retrofit/rehabilitation techniques, as the latter have been identified, tested and certified previously in the Lab.    During the entire duration of the project a series of workshops and training sessions will be organised in Nepal in order to interact with the local administration as well as the engineering and educational community. This interaction is deemed vital for the co-development of new concepts, the transfer of know-how and the sustainable construction of schools in both rural and urban areas of Nepal.","The Global Challenges Research Fund (GCRF) supports cutting-edge research to address challenges faced by developing countries. The fund addresses the UN sustainable development goals. It aims to maximise the impact of research and innovation to improve lives and opportunity in the developing world."],
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      "title_narrative":["Integrated 'on-chip' optical coherence tomography (OCT) system for point of care imaging diagnostics"],
      "description_narrative":["The research context: Nepal is classified as one of the lowest income countries on the Development Assistance Committee (DAC) list and the general health of the population is considered to be poor by most measures, even in comparison with the rest of Asia. Access to healthcare is severely restricted, particularly in rural regions, which is undoubtedly a limiting factor to progress, generally. We have identified a specific unmet clinical need within Nepal that is fully aligned with this call for proposals; aided as it could be by the provision of affordable, point-of-care imaging diagnostics. There is an unusually high prevalence (up to 43%) of the population in Nepal suffering from chronic obstructive pulmonary disease (COPD) and this has been the number one cause of death (>9%) there in recent years. This is thought to arise principally as a result of poor indoor air quality, with the condition being even more acute in difficult to reach, both geographically and economically, rural regions. It is particularly high amongst women, which may be largely attributable to the deeply embedded culture of indoor cooking and heating with biomass fuels  Aims and objectives: Our aim is to develop a low cost miniaturized, integrated chip-based optical coherence tomography (OCT) based diagnostic tool which will provide a transformative change to the level of sophistication that access to such clinical imaging technology can bring to bear on COPD diagnosis and therapy. The key advance will stem from transitioning the fibre based interferometer at the heart of commercial OCT systems onto the silicon photonics chip, which will enable system complexity and cost reductions through manufacturing scalability. Silicon photonics is aptly suited to this because it is transparent at the target operating wavelength (1300nm) of most OCT systems and the required interferometer components have now all been demonstrated in isolation. Manufacturing of these sub-micron optical devices can be massively scaled at lower cost and to extremely high tolerances using the global passive fabrication infrastructure that has been built up around the telecommunications industry. In addition, many of these components have now also been realised in the silicon nitride (SiN) platform, extending capabilities down towards the visible range, which is particularly relevant to certain biomedical imaging regimes. We will develop SiN based interferometers in parallel with the silicon devices through wavelength scaled common optical circuit designs as proof of concept. Finally, we will take the ambitious step of developing a complete, fibre-less chip based solution by hybrid integration of miniature optical sources with the silicon/SiN based interferometers.  Potential applications and benefits: The vision of a low complexity, low cost, miniature OCT system incorporated within existing bronchoscopy or catheter based medical devices that could be used along with commercially available data acquisition hardware and analytical software on a mobile platform is within reach. Such a system can provide the necessary access to a sophisticated imaging diagnostic tool that could displace basic spirometry and even fibre based bronchoscopy as the gold standard for early diagnosis of COPD. Its greatest benefit will be felt, initially, within remote regions of our partner LMIC country, Nepal where a high prevalence of the disease is exemplified and where access to such facilities is limited by both geography and economy. Improvements in resolution and speed for tissue imaging can also be expected to help improve our understanding of COPD progression in a fundamental way. For example the development and widespread adoption of the proposed OCT technology would generate population specific datasets of high quality for use by researchers and clinicians.","The Global Challenges Research Fund (GCRF) supports cutting-edge research to address challenges faced by developing countries. The fund addresses the UN sustainable development goals. It aims to maximise the impact of research and innovation to improve lives and opportunity in the developing world."],
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      "title_narrative":["Humanitarian, Engineering and Energy for Displacement (HEED)"],
      "description_narrative":["To address this global challenge call, a multi-sectorial consortium led by two UK Universities (Coventry University and the University of Oxford),  with an international civil society partner and developing country researchers (Practical Action) and an international sustainable energy and ICT social enterprise consultancy (Scene Connect), has been formed to provide original research on energy for displaced populations. The overarching aim of this proposal is the implementation of safe and sustainable energy solutions for lighting, electrification, cooking, heating and cooling, and water and sanitation that promotes development and improves wellbeing in displaced communities, and the associated ICT-based business processes that enable replication and scalability.   The consortium aims to deliver an innovative research programme to understand how the energy needs of displaced people can be met a safe, sustainable manner. The project seeks to provide research on energy needs in self-settlements, host communities and refugee camps, and understand how sustainable energy solutions can be delivered. Based on this evidence, the consortium will engage a range of energy stakeholders to design and implement sustainable energy solutions. The role of sustainable sources of energy in providing energy services for refugee protection is a critical area for innovation and scale-up. While the focus within refugee camps is often on solar energy (due to the advanced nature of this technology and the natural solar resource available in many developing countries), there are increasing opportunities for the use of renewable biomass and biogas, wind generators, micro-hydro, geothermal, LPG, and waste recycling. Similarly, renewable micro-grids and hybrid systems are often proposed as options for enabling flexible solutions that can be supplied quickly and efficiently in humanitarian emergencies. In addition, the feasibility and ability of low-cost, remote monitoring wireless systems to manage assets and pre-empt operations and maintenance issues of energy infrastructure require further investigation. Digital infrastructure could potentially be created to provide the private sector the assurance it requires to enter this market which has traditionally been the domain of humanitarian actors. All these scientific areas are worthy of research.   The programme of work will provide energy access to four displaced populations in Rwanda (Kigeme, Nyabiheke, Gihembe refugee camps) and Nepal (Tibet and Bhutan refugees and Kathmandu climate change refugees) and assess the impact of the provision of energy on people's lives against the UN Sustainable Development Goals (SDGs) and create impact through scalability of the energy solutions. Through the program we aim to build capacity with partner countries and organisations. To deliver this, the progress and outputs of the project will be disseminated through the UNESCO UNITWIN Network in Humanitarian Engineering (in which Coventry University is the global lead) as well as specially designed workshops to be held in Africa and Asia over the three year programme period. Ultimately, the project hopes to create a paradigm shift in the way refugees see themselves, instead of  'beneficiaries' dependent on handouts, they will be able to \"HELP\" themselves and become agents able to choose, produce, consume and take part in the running of their own communities.","The Global Challenges Research Fund (GCRF) supports cutting-edge research to address challenges faced by developing countries. The fund addresses the UN sustainable development goals. It aims to maximise the impact of research and innovation to improve lives and opportunity in the developing world."],
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      "title_narrative":["Surveys for Urban Equity: getting, and using, the data needed to respond to neglected non-communicable diseases in urban areas in LMICs"],
      "description_narrative":["Non-communicable diseases (NCD) are a major public health issue in South Asia (S Asia), accounting for 60% of deaths. Urbanisation is a key driver, increasing mental stress and injuries and risk factors such as tobacco use, poor diet and inadequate physical activity. Public health decision-makers in LMICs need unbiased, precise and accessibly-presented data to inform equitable urban development. Nationally representative surveys are the main data source used to inform decision-making in LMICs, e.g. Demographic and Health Surveys (DHS) and STEPS NCD Risk Factor Surveillance are used in over 90 LMICs. This approach has many problems: it excludes unofficial poor settlements and peri-urban areas beyond administrative boundaries; definitions of a 'household' overlook multiple occupancy by poor urbanites; current methods for ranking wealth are not sensitive to urban poverty; and NCDs currently assessed in these surveys do not include injuries and mental ill-health, conditions that disproportionately affect the urban poor. These methodological constraints leave policy makers with no way of understanding or responding to the NCD burden and inequities found within urban areas in LMICs. Furthermore, the way data is currently presented - in long wordy reports - undermines decision-makers' ability to find and interpret data for planning and managing health programmes. We will capitalise on existing partnerships and develop new ones, to i) identify and test questions on mental health and injuries, ii) test cheap and efficient novel methods to reduce bias in urban surveys iii) explore alternative approaches to defining households, measuring and ranking wealth iv) develop data visualisation tools to support decision-makers' use of survey data. We will conduct this foundation work in Nepal, Bangladesh and Vietnam as their different urban characteristics increase our works applicability to other LMICs and we have existing strong partnerships. We will hold two meetings and facilitate ongoing interaction with international and national bodies to share expertise and build capabilities on the novel survey methods, measures of wealth and NCDs, data visualisation and use of data to address urban inequities.  We will conduct a systematic search of questionnaires and draw on our own work assessing injuries and mental health to identify the best questions for LMIC urban areas. We will finalise the questionnaire in collaboration with government stakeholders after checking its comprehensibility in urban slums. We will pilot our novel survey sampling and mapping methods in Kathmandu, where our initial pilot of these methods was curtailed by the 2015 earthquake. Our novel methods use satellite imagery, mobile phone and census data, to identify the entire urban population including those not captured by the census. Once sampled, we will use a web-based app to accurately map communities. Smaller feasibility studies of the methods and developed questionnaire will be conducted in Hanoi and Dhaka. We will explore household types and identify wealth indicators in urban slums. Using our pilot data, we will explore associations between household consumption, assets and income to develop an appropriate measure of urban wealth. In each country, we will assess the extent to which data is used in urban planning and management through interviews with decision-makers. Through the establishment of communities of practice within municipalities, we will co-produce appropriate data visualisation tools to support planning and management. This foundation grant has the potential to i) transform survey methods used in all LMICs, enabling more accurate assessment of health inequities in urban areas ii) provide questions on mental health and injuries for use in other surveys in LMICs, and iii) ensure data informs the health-sector response to NCDs in LMICs.","The Global Challenges Research Fund (GCRF) supports cutting-edge research to address challenges faced by developing countries. The fund addresses the UN sustainable development goals. It aims to maximise the impact of research and innovation to improve lives and opportunity in the developing world."],
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      "title_narrative":["Analysing the policy and governance environment for NCD control, and identifying potential policy options."],
      "description_narrative":["The Non-Communicable Diseases (NCDs) have emerged as the most important global threat to human health and wellbeing. Four major NCDs - heart disease, cancers, diabetes, respiratory diseases - cause the deaths of 38 million people every year, of whom 16 million die prematurely (under the age of 70 years). These diseases cause chronic illness and disability and are a source of suffering and financial hardship for individuals, families, communities and health systems struggling to provide continuous care for people with long-term health problems. The NCDs affect populations across the globe - and they are now the leading cause of death in many low and middle income countries.   Many of these diseases are driven by exposure to commercial products - tobacco, alcohol, highly processed foods (including the so-called 'junk foods') which have high levels of salt, sugar and/or trans-fats. Evidence shows that limiting exposure to these products is likely to bring health benefits, but it is often very difficult for individuals to sustain 'healthy behaviours' over their lifetime. Evidence-informed prevention strategies most likely to bring benefit to the largest numbers of people include: regulating exposure, e.g. taxation on products known to be health-reducing, such as sugary drinks; restricting access, e.g. no sales of tobacco to children, non-smoking zones in public spaces; or reformulating products to make them less likely to cause harm, e.g. lowering the salt content of processed foods. Such strategies, when implemented well, can have a significant impact on improving population health.   However, Governments face many challenges in implementing these policies - for example, there may be resistance from strong and powerful commercial companies that have a vested interest in selling their products. Moreover, in many countries, there is little policy experience in tackling the NCDs.   In this project we propose to undertake detailed policy analyses to identify acceptable and feasible options for Governments in both low- and middle-income countries to tackle the growing burden of NCDs in their countries. Our work will focus on three policy areas - control of sugar, salt and trans-fats in processed foods. We will work with researchers in Afghanistan, Bangladesh, Iran, Nepal, Pakistan, Tunisia and Vietnam to identify how the Government in each country is currently tackling NCDs. We will then map out the influences on policy options operating in each country. Such influences are likely to include the role of powerful stakeholders such as the food producing and selling industries, the media, the medical establishment, the Ministry of trade, etc. We will also identify whether any civil society groups (in some countries this might mean, for example, groups of parents concerned about junk-food marketing to children; in other countries it will include groups of patients suffering from diet-related NCDs such as diabetes) are working on policy issues. We will conduct interviews with key stakeholders to better understand the opportunities for seeing effective policy implemented for controlling sugar, salt and/or trans-fats, as well as identifying the challenges and barriers to putting effective policy options into operation.   This kind of health analysis requires a specific skill set which is not common in many countries. As part of our project we will therefore establish and strengthen the capacity of a network of researchers from all 8 countries (including the UK), who will support each other to carry out the analyses and interpret the findings. We will foster cross-learning of policy successes between different countries. In addition, we will promote engagement and dialogue with a wide variety of stakeholders in each country throughout the lifetime of the project in order to ensure that the findings of the research carry meaning and weight in policy decisions to improve population health both in the 7 research countries and beyond.","The Global Challenges Research Fund (GCRF) supports cutting-edge research to address challenges faced by developing countries. The fund addresses the UN sustainable development goals. It aims to maximise the impact of research and innovation to improve lives and opportunity in the developing world."],
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      "title_narrative":["A Network for Studying Psychological Resilience in Low and Middle-Income Countries (NESP)"],
      "description_narrative":["Vulnerability to or resilience to the commonest mental health disorders (depression, anxiety, drug and alcohol misuse) is related to the combination of genetic susceptibility, early life factors and an individual's current environment. Studies, over 95% of which have been confined to high income countries (HICs), have confirmed the importance of genes, development and adult environment. However, very little is known of these factors in low and middle-income countries (LMICs), where the burden of such common mental health disorders is even more substantial than in HICs.  Here we propose a powerful network of global leaders to analyse the key factors in three contrasting LMIC settings in three regions of the world, Nepal, Malawi and Costa Rica. This will enable us systematically to determine the processes leading to vulnerability or resilience to common disorders of mental health and exploit this knowledge, enabled by globally-leading data sciences and within-country expertise, to develop specific approaches to reinforce resilience and support prevention, diagnosis and treatment.  Our approach is highly multidisciplinary, combining genetic, clinical and social sciences expertise to provide a comprehensive view of an individual's genetics, development and environment. We will combine this expertise with world-leading informatics capacity to create a network for the study of psychological resilience across diverse environments and economies.","The Global Challenges Research Fund (GCRF) supports cutting-edge research to address challenges faced by developing countries. The fund addresses the UN sustainable development goals. It aims to maximise the impact of research and innovation to improve lives and opportunity in the developing world."],
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