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programme funds research-driven partnerships between institutions in low and middle income countries (LMICs) and in the UK. \nThe Centres undertake high quality research and strengthen LMIC institutional capacity to undertake, manage and disseminate high-quality applied health research. \nThe Global Health Research Centres programme funds high quality applied health research in LMICs and supports the development of a critical mass of sustainable, competitive research capacity. \nBy delivering high quality research evidence and strengthening research capacity at all levels, our Global Health Research Centres will improve health outcomes for people in LMICs and support sustainable growth of the LMIC research ecosystem.. The Global Health Research Centres programme funds ambitious, transformative, innovative and collaborative consortia of research institutions in the UK and in LMICs that are eligible for Official Development Assistance (ODA). High quality research and research capacity strengthening in LMICs are equally essential components of the programme. \n\nEach funding call addresses an area where there is a need for coordinated, high quality research in LMICs to increase the global evidence base. The first funding call will fund and designate NIHR Global Health Research Centres in non-communicable diseases.\nCentres also have a focus on capacity building and training in partner LMIC institutions, through:\n-strengthening career pathways for researchers, from masters students to senior academics\n-developing and retaining a trained and networked global cohort of experts and future research leaders\n-supporting the training and development of research managers and other non-academic staff.\n \n ID: GB-GOV-10-CENTRES_1_203246\nTitle: NIHR Global Health Research Centres 1: Non-communicable Disease control in West Africa (Stop-NCD)\nDescription: A UK and low-and-middle-income-country (LMIC) partnership that aims to contribute to improved health of populations in West Africa by strengthening capacity for high-quality research and developing and implementing contextually adapted packages of interventions for prevention, diagnosis and management of non-communicable diseases (NCDs) at community and primary care levels The partnership involves two joint lead organisations - Ghana College of Physicians and Surgeons and the London School of Hygiene & Tropical Medicine and three partners namely Ashesi University, Laboratoire d'Etudes et de Recherche sur les Dynamiques Sociales et le Développement Local (LASDEL) and Université Catholique de l'Afrique de l'Ouest - Unité Universitaire at Bobo-Dioulasso (UCAOUUB) Between October 2022 and September 2027, we will work in three West African countries namely Ghana, Burkina Faso and Niger with varying ethnic-socio-cultural-economic environments to develop, implement and evaluate ways of improving control of hypertension, diabetes and mental health conditions related to chronic illness such as stress, anxiety and depression. We will start by analysing the roles of key stakeholders (patients and communities, health workers, managers, policymakers) in the development, provision, and use of NCD policies, programmes and services in each country, using appropriate methods such as analysis of available data, observations and interviews. Working closely with those stakeholders, we will co-produce packages of interventions for improving NCD control. This package will include adapting international guidelines to local contexts and supporting healthcare workers in implementing these, and establishing a community-based prevention, early-detection and management of NCDs. We will implement and rigorously evaluate the interventions packages for their costs and effectiveness, assess their potential for wide-scale application, and will identify transferable lessons for improving NCD control beyond these three countries Throughout our work, we will: (a) firstly strengthen individual skills and expertise, organisational systems and processes and system-wide networking capabilities and leadership of researchers to conduct high-quality research, secondly local communities to engage with, and understand, how to enable healthy lifestyles and thirdly, policymakers and practitioners to use evidence-informed interventions. (b) engage with key stakeholders i.e. patients, health workers, managers for consulting on their views, preferences and expectations, sharing results as they emerge and facilitating uptake of research results into their decisions and practices; and (c) maintain equitable national and international partnerships, through shared leadership involving both senior and earlier-career staff, and equally distributed management responsibilities. We will share research results with different audiences, through easyto-understand leaflets, briefs, audio-visual materials, adapted guidelines, policy dialogues, academic publications and conference presentations.. The Centre’s goal is to contribute to improved health of West African populations through comprehensive and sustainable capacity strengthening for high-quality applied research and through developing and implementing contextually adapted packages of interventions for prevention, diagnosis and management of hypertension, diabetes and related common mental disorders such as anxiety, stress and depression. Our ambition is to leave a legacy of person-centred, integrated (not disease-specific) and system-wide (combining staff, structures, resources at multiple levels) responses to inter-connected NCDs at community and primary care levels, through African-led research by high-calibre scholars embedded within supportive institutions, networks and policy environments. This will all ultimately contribute to the reduction in premature mortality from NCDs, to improved health, wellbeing and socio-economic gains. Specific objectives are to: 1. Deepen understanding of contextual influences and effective pathways to prevention, diagnosis and management of NCDs in West Africa. 2. Co-produce with key stakeholders, contextually adapted packages of interventions for prevention, diagnosis and management of NCDs at community and primary care levels; and conduct formative process evaluation. 3. Implement the intervention package through existing health systems in each country, and evaluate its feasibility, acceptability, clinical effects, equitable reach and cost-effectiveness. 4. Comprehensively and sustainably strengthen capacities of researchers, communities and decision-makers, for high-quality applied NCD research and its uptake. 5. Ensure effective research communication and uptake into policies and practices of patients, communities, service providers, and national/West African decision-makers. 6. Continuously engage with key stakeholders at community, subnational, national levels within each country and within West Africa. 7. Establish and maintain equitable partnerships across West African and UK applicants, through shared leadership and governance arrangements.\n \n ID: GB-GOV-10-CENTRES_1_203247\nTitle: NIHR Global Health Research Centres 1: NIHR Global Health Research Centre for Non-communicable Diseases and Environmental Change\nDescription: A UK and low-and-middle-income-country (LMIC) partnership to create a centre of excellence on non-communicable diseases (NCDs) and global environmental change in Bangladesh, India and Indonesia offering world-leading research, training and policy advice for health equity. LMICs face dual, intertwined challenges of a rapidly growing burden of NCDs and the existential threat of global environmental change. In addition, health systems in LMICs face specific challenges in delivering high-quality, equitable services for NCDs prevention and care, especially for marginalised populations most impacted by environmental change. Despite an increasingly recognised imperative for action, there is a paucity of evidence on cost-effective interventions to address major challenges emerging at the nexus of NCDs and environmental change. Our Centre will focus on three countries highly impacted by the dual challenges of NCDs and environmental change. Partner institutions are the George Institute in New Delhi, India, Imperial College London, International Centre for Diarrhoeal Disease Research, Bangladesh in Dhaka, Sri Ramachandra Institute of Higher Education & Research in Chennai and University of Brawijaya in Malang. This project will start in October 2022 and runs for five years ending in September 2027. We will address crucial knowledge gaps through three integrated research themes: 1. Strengthening primary health care and essential public health services for NCD prevention and management in communities affected by rapid environmental change; 2. Developing and evaluating multi-sectoral interventions that have dual benefits in reducing the burden of NCDs and hazardous environmental exposures at the population level; 3. Strengthening engagement of communities in the generation and use of evidence and advocacy for health and environment policy change. All interventions will have a focus on reducing inequities in addition to cost-effectively improving health outcomes. An example of the integrated research program relates to the burning of plastic wastes in Indonesia. In the same communities, dual benefit interventions (e.g. reduced burning within the context of improved waste management strategies) and an innovative technology-based primary health care model will focus on the prevention of exposure to environmental hazards, while also promoting screening for and management of airpollution related NCDs, such as chronic obstructive pulmonary disease. Common systems to collect data for both implementation and evaluation of such complementary interventions will be deployed. Throughout the research lifecycle, our Centre will emphasise systematic and meaningful engagement of community members and policymakers – including through co-design and evaluation of interventions. In addition to delivering high-quality impactful research, we will focus also on research capacity strengthening and will deliver several training and development opportunities targeting three critical career periods: pre-doctoral, early post-doctoral and transitioning to senior leadership. Recruitment into these training opportunities and posts will be based on gender parity and we will monitor and report diversity in career progression for all staff and students across academic career levels. We will strengthen research capability at institution, network and ecosystems levels to enable LMIC-led production and use of highquality evidence at the nexus of NCDs and environmental change.. Our aim is to be a recognised centre of excellence on NCDs and global environmental change in LMICs, co-producing world leading implementation research with local communities, strengthening research capability, advocacy, and policy for health equity. Objectives To establish a common data platform across all three countries that can comprehensively capture community environmental risks, behavioural risk factors and disease management To expand existing PHC strengthening strategies (COBRA-BPS in Bangladesh, SMARThealth in India and Indonesia;) to incorporate environmental risks and a broader range of disease conditions using a community co-design approach To develop, implement and evaluate multi-sectoral interventions in each country which address key dual threats to NCDs and the environment (water salinity, air pollution, poor dietary diversity) To understand the nature of Community Engagement and Involvement (CEI) in the evidence to policy process in each of our focus countries and identify opportunities for enhancement To evaluate the process for CEI in co-production and collaborative engagement activities undertaken within our Research Programme and to understand how and how well the CEI activities have been implemented under these themes To strengthen Research Capability in four domains identified in our framework, covering individuals, institutions, networks and ecosystems\n \n ID: GB-GOV-10-CENTRES_1_203248\nTitle: NIHR Global Health Research Centres 1: Centre for Improving Mental and Physical Health Together\nDescription: A UK and low- and middle-income country (LMIC) research partnership aiming to improve the lives of those experiencing noncommunicable diseases (NCDs) such as heart disease, depression and diabetes in Pakistan and Afghanistan, and the relevant systems available to those populations. The project will also develop the research capacity of related organisations working in these countries. NCDs are rapidly increasing and are now responsible for most deaths and disabilities globally. In Afghanistan and Pakistan, countries with limited resources and affected by recent conflicts, NCDs risk crippling fragile health systems and economies. In response, health systems and policies are evolving and diversifying, e.g. non-specialist healthcare workers share tasks usually delivered by specialists; and private sector organisations are increasingly providing health coverage. There is a knowledge gap, however, on effective, scalable interventions in low-resource, conflict-affected settings. This provides timely opportunities to develop, test and embed evidence-based approaches to address NCDs. In preparing this project, we held consultations with practitioners, affected communities and policymakers in both countries, who identified a time-critical need to strengthen capacity in discovering and implementing affordable effective solutions to address NCDs. We also referred to a recent research prioritisation process undertaken by the Higher Education Commission in Pakistan. The long-term aim is to promote mental and physical health in Afghanistan and Pakistan by reducing premature deaths and disabilities caused by NCDs. In this proposal, we focus on three of the four key NCDs: common mental disorders (depression and anxiety), heart conditions, and diabetes. We will evaluate approaches to prevent and treat these, targeting those most at risk, and giving mental health parity alongside physical health. Firstly, we will identify the most practical, affordable solutions. A group of academics, practitioners and policymakers will prioritise a shortlist of solutions, including those offered to individuals and communities as well as those implemented at population level. Using various research methods, we will assess the health and economic impact of these solutions. Secondly, we will train researchers, particularly women scholars, to become tomorrow’s research leaders. The trainees will include 8 Masters, 16 Doctoral, 6 Post-doctoral scholars (at least 60% women) and 70 research and support staff (short-term courses). Participating institutions will create competitive faculty positions to retain these scholars beyond the funding period. We will enhance health research standards in our institutions whilst promoting an environment in the two countries that demands, understands and utilises research to inform policy and practice. We will use Community Advisory Panels to engage with patients and families. Following training, Panels will help design, conduct, and disseminate research, bringing practitioners and policymakers together to inform the research and share findings. Multiple channels–journal articles, policy briefs, print and social media– will be used to make findings accessible to academic and lay audiences. Over time, we will develop strong, diverse academic leadership bringing wider health, societal, and economic benefits to the region. Jointly led by Aga Khan University, and the University of York, this global project network brings together experts in diabetes, cardiovascular disease, mental health and global public health research from Pakistan (Aga Khan University; Khyber Medical University; The Institute of Psychiatry; Baqai Institute of Diabetology & Endocrinology at the Baqai Medical University; The Initiative), Afghanistan (HealthNet TPO; Kabul University of Medical Sciences) and the UK (University of York; University of Liverpool; University of Edinburgh). The project will start in October 2022 and run until September 2027.. The research plan has ten objectives which are related to research and capacity strengthening activities. All objectives are in line with the overall Centre aims to i) develop and evaluate innovative and sustainable models to deliver individual and population-level interventions, in order to strengthen health systems and support policies for equitable roll-out of strategies for the prevention and treatment of non-communicable diseases (NCDs) and; ii) to strengthen capacity in applied health research and research governance, prioritising gender equality. The Centre objectives are as follows: • By the end of Year 1 of the project, we will complete a valueof-information analysis and stakeholder prioritisation exercise with policy makers, practitioners and community advisory panels. This will help us identify the most suitable interventions we could trial and to assess their feasibility in local contexts in Pakistan and Afghanistan. • By the end of Year 1 we will identify suitable data sources, refine/expand existing population cohorts, digitise data collection and prepare study sites. This will ensure the Centre is ready to carry out identified interventions from Year 2 onwards. • By the end of Year 1 we will assess the existing capacity within the project partner organisations and health, policy and community systems in Pakistan and Afghanistan, in order to develop a tailored action plan with a special emphasis on gender equity. • By the end of Year 1 we will develop a research training and mentorship programme for researchers, practitioners and policymakers. • By the end of Year 1 we will establish research governance functions, Community Engagement and Involvement and Policy Fora. This is in order to share best research governance practice, to receive advice from key stakeholders and to ensure communication between the project and stakeholders is effective. • By the end of Year 4 we will evaluate the (cost-)effectiveness, equity and implementation of selected interventions (Objective 1) for modifying NCD risk factors and/or improving NCD outcomes through randomised controlled trials and health economic approaches. • By the end of Year4 we will deliver a training programme to project members and key stakeholders, strengthen institutional capacity in data and financial management within partner organisations and strengthen applied health research courses/degrees in partner organisations. • By the end of Year 3 we will conduct a mid-term review of all training and capacity strengthening plans and activities. • By the end of Year 5 we will work with key stakeholder fora to translate our project findings into policy and practice and enact plans to sustain research and its impact. We will use our links to extend the Centre's impact across the World Health Organization Eastern Mediterranean Region. • By the end of Year 5 we will support project trainees to secure follow-on fellowships or extramural funding and conduct an end of project impact- assessment.\n \n ID: GB-GOV-10-CENTRES_1_203257\nTitle: NIHR Global Health Research Centres 1: NIHR Global Health Research Centre for multiple long-term conditions\nDescription: A UK and low-and-middle-income-country (LMIC) partnership that aims to improve the care for people with multiple long-term conditions (MLTC) through innovative health system level interventions in India and Nepal. The proposed project will be co-led by investigators from the Public Health Foundation of India and University of Leicester in partnership with co-applicant institutions - All India Institute of Medical Sciences, Jodhpur (India), Health Related Information Dissemination Amongst Youth (India) and Kathmandu Medical College (Nepal). Patients with MLTCs in India and Nepal typically display worsened health and increased adverse outcome risk. Additionally, healthcare access is often limited in marginalized communities, and MLTC healthcare service delivery can be fragmented and inefficient. To address this, we will implement health system level interventions in Visakhapatnam (India), Jodhpur (India) and Bhaktapur and Kavrepalanchowk (Nepal). The interventions will meaningfully engage patients, their communities, and other relevant stakeholders. We will use their views to co-design a person or patient-centred care model that works for them. In addition, we will build the capacity of patients, providers, researchers, and research supporting staff to ensure that the proposed activities under the project are implemented and sustained beyond the project end date. The project activities will begin from October 2022 and end in September 2027.. In the short term, we will analyse existing and new data to understand the patterns of multiple long-term conditions in both countries, how the health systems provide care and identify the best method to deliver patient-centred and responsive care for people living with these conditions. We will conduct community conversations and interviews among people living with these conditions and their caregivers, healthcare providers and the wider community to identify their experiences, needs, beliefs and living environment. We will identify “Community Champions”, who will represent people living with multiple long-term conditions, to work with us to help develop a responsive care model. In the medium term, we will propose interventions or a treatment package that respect people’s culture, beliefs, and environment and work in close partnership with the Community Champions to create a network of patients. We will test the interventions to understand if they are appropriate and adequately adapted to the context and if they could be integrated into the pre-existing health system. The interventions will use digital technology (an electronic decision support system, telemedicine) to provide care. Simultaneously, we will build the capacity of young researchers through varied educational programmes to address multiple long-term conditions and bolster institutional capacity to advance research. In the long term, we will work with the governments of India and Nepal to address multiple long-term conditions (MLTC) and embed the care model in the respective health systems to improve population health outcomes. Findings and materials developed by this collaboration will be widely disseminated and shared to improve the quality of lives of people with multiple long-term conditions, strengthen the health systems, and benefit societies and national economies.\n \n ID: GB-GOV-10-CENTRES_1_203266\nTitle: NIHR Global Health Research Centres 1: Community Management of Long-Term Conditions in Latin America.\nDescription: A UK and low-and-middle-income-country (LMIC) partnership that aims to strengthen community-based care for people with diabetes, cardiovascular disease, respiratory conditions and mental health problems in Latin America. The partnership will develop a world-class research centre with a regional focus in three Latin American countries – Bolivia, Colombia and Guatemala, to strengthen research and service capacity, conduct high quality research and ultimately improve quality of life and disease specific outcomes for individuals with longterm NCDs, including those from often neglected indigenous communities. Supported by Queen Mary University of London (UK), the Centre will link a leading university in Colombia, Universidad Javeriana, as a regional hub with two universities namely in Bolivia (Universidad Franz Tamayo) and Guatemala (Universidad Rafael Landívar). Studies will investigate the best way to manage long-term conditions within the community. The approach involves using resource-oriented interventions that help people use their strengths and resources to reduce lifestyle factors and behaviours linked to developing long-term conditions. This research will adapt and test these interventions to see whether they have a beneficial effect and to investigate the best way to deliver them in health care services. The research will be implemented from 2022 to 2027. The project will develop the skills of local researchers and clinicians to help sustain the Centre and increase impact. A PhD and Masters programme will run in Colombia to provide formal training to students from all three countries and will help us develop a network of researchers, linking them with others in the region and internationally. The research will be developed and discussed in collaboration with advisory groups. These groups will involve people with long-term conditions, clinicians in community services, community organisations and representatives of local governments. There will be a particular focus on people from indigenous communities as active participants and collaborators, as the impact of long-term conditions is greatest for indigenous people. The project activities will begin from October 2022 and end in September 2027.. The overall objective of this project is to build a world-class research centre with a regional focus in Latin America to strengthen research and service capacity, conduct high quality research and ultimately improve quality of life and disease specific outcomes for individuals with long-term Non-Communicable Diseases (NCDs), including those from often neglected indigenous communities. Short-term aims: build relationships between partners to establish a shared vision, link with local stakeholders, initiate the postgraduate training programme, and identify future research leaders. Medium-term: consolidate capacity strengthening activities through cross cutting, high quality and priority driven research studies testing effectiveness and implementation of appropriate interventions for patients with long-term NCDs. Long-term: sustain and grow the Centre through a critical mass of researchers with regional and international collaborations, complementary skill sets and top-level expertise to lead research groups and generate further funding; the Centre will provide relevant research evidence and influence policies to improve health and social outcomes for patients with NCDs.\n \n ID: GB-GOV-10-CENTRES_1_LP_205661\nTitle: NIHR Global Health Research Centres: Learning Research Partner\nDescription: A UK and low-and-middle-income-country (LMIC) partnership that aims to support, embed and advance best-in-class methodological approaches - spanning MEL, research on research, and continuous improvement - across the lifetime of the Centres programme. The Learning Research Partner (LRP) will support all five (5) GHR Centres and stakeholders to develop and implement equitable and participatory MEL approaches including facilitating training and learning opportunities.. This project has four objectives:\n\na. Exemplify the value of equitable and participatory monitoring, evaluation and learning approaches through supporting the Centres, providing insights of good practice and facilitating the design and delivery of training activities.\n\nb. Work with Centres award-holders and NIHR programme teams to design and set up sustainable routes to enable shared learning and engagement in research capacity strengthening (RCS), community engagement and involvement (CEI), knowledge management etc. through e.g. learning, training platforms, networking events, workshops, seminars and/or other events.\n\nc. Facilitate the development of an overarching programme-level Centres monitoring, evaluation and learning framework and strategy which is contextually-relevant and which both incorporates and supports Centres’ own development of participatory monitoring, evaluation and learning strategies and approaches at local level.\n\nd. Work collaboratively with Centres award-holders and wider partners to consider which topics are suitable for formal ‘research on research’ studies across the\nprogramme, and consider potential for research training of individuals (e.g. via LMIC-based PhD studentships).\n\n", "_version_":1859050969852018688 }] } }